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The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor.
J Neurol Sci. 2007 Sep 15; 260(1-2):199-203.JN

Abstract

Deep brain stimulation (DBS) of the ventral intermediate (Vim) nucleus of the thalamus has been the target of choice for patients with disabling essential tremor or medication refractory parkinsonian tremor. Recently there is evidence that the subthalamic nucleus (STN) should be the targets for patients with tremor associated with Parkinson's disease (PD). To assess the effects of STN DBS on parkinsonian tremor, eight consecutive patients with PD and disabling tremor were videotaped using a standardized tremor protocol. Evaluations were performed at least 12 h after last dose of medication with the DBS turned off followed by optimal DBS on state. A rater blinded to DBS status evaluated randomized video segments with the tremor components of the Unified Parkinson Disease Rating Scale (UPDRS) and Tremor Rating Scale (TRS). Compared with DBS off state there were significant improvements in mean UPDRS tremor score 79.4% (p=0.008), total TRS score 69.9% (p=0.008) and upper extremity 92.5% (p=0.008) TRS subscore. Functional improvement was noted with pouring liquids. Our findings provide support that STN DBS is an effective treatment of tremor associated with PD.

Authors+Show Affiliations

Department of Neurology, Baylor College of Medicine, United States. neurodoc01@sbcglobal.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17561121

Citation

Diamond, Alan, et al. "The Effects of Subthalamic Nucleus Deep Brain Stimulation On Parkinsonian Tremor." Journal of the Neurological Sciences, vol. 260, no. 1-2, 2007, pp. 199-203.
Diamond A, Shahed J, Jankovic J. The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor. J Neurol Sci. 2007;260(1-2):199-203.
Diamond, A., Shahed, J., & Jankovic, J. (2007). The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor. Journal of the Neurological Sciences, 260(1-2), 199-203.
Diamond A, Shahed J, Jankovic J. The Effects of Subthalamic Nucleus Deep Brain Stimulation On Parkinsonian Tremor. J Neurol Sci. 2007 Sep 15;260(1-2):199-203. PubMed PMID: 17561121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor. AU - Diamond,Alan, AU - Shahed,Joohi, AU - Jankovic,Joseph, Y1 - 2007/06/11/ PY - 2006/12/28/received PY - 2007/05/02/revised PY - 2007/05/07/accepted PY - 2007/6/15/pubmed PY - 2007/12/7/medline PY - 2007/6/15/entrez SP - 199 EP - 203 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 260 IS - 1-2 N2 - Deep brain stimulation (DBS) of the ventral intermediate (Vim) nucleus of the thalamus has been the target of choice for patients with disabling essential tremor or medication refractory parkinsonian tremor. Recently there is evidence that the subthalamic nucleus (STN) should be the targets for patients with tremor associated with Parkinson's disease (PD). To assess the effects of STN DBS on parkinsonian tremor, eight consecutive patients with PD and disabling tremor were videotaped using a standardized tremor protocol. Evaluations were performed at least 12 h after last dose of medication with the DBS turned off followed by optimal DBS on state. A rater blinded to DBS status evaluated randomized video segments with the tremor components of the Unified Parkinson Disease Rating Scale (UPDRS) and Tremor Rating Scale (TRS). Compared with DBS off state there were significant improvements in mean UPDRS tremor score 79.4% (p=0.008), total TRS score 69.9% (p=0.008) and upper extremity 92.5% (p=0.008) TRS subscore. Functional improvement was noted with pouring liquids. Our findings provide support that STN DBS is an effective treatment of tremor associated with PD. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17561121/The_effects_of_subthalamic_nucleus_deep_brain_stimulation_on_parkinsonian_tremor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00322-X DB - PRIME DP - Unbound Medicine ER -