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Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma.
Ophthalmology. 2007 Dec; 114(12):2238-43.O

Abstract

PURPOSE

To evaluate the diagnostic capability of optical coherence tomography (Stratus OCT 3) for early glaucoma in Asian Indian eyes.

DESIGN

Cross-sectional observational study.

PARTICIPANTS

Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early glaucoma was diagnosed in presence of open angles, characteristic glaucomatous optic disc changes correlating with the visual field on automated perimetry (visual field defect fulfilling at least 2 of Anderson and Patella's 3 criteria with mean deviation > or = -6 dB). Normals had visual acuity > or =20/30, intraocular pressure <22 mmHg with normal optic disc and fields and no ocular abnormality.

METHODS

All patients underwent complete ophthalmic evaluation including visual field examination (24-2/30-2 SITA standard program) and imaging with Stratus OCT 3.

MAIN OUTCOME MEASURES

Sensitivity, specificity, positive and negative predictive values, area under the receiving operating characteristic curve and likelihood ratios were calculated for various Stratus OCT 3 parameters.

RESULTS

Seventy-two eyes (72 patients) with early glaucoma and 96 eyes (96 normal subjects) were analyzed. The inferior maximum parameter had the best combination of sensitivity and specificity, 75% (95% confidence interval [CI], 70.2-79.8%) and 89.6% (95% CI, 82.6-96.6%), respectively. The 6-o'clock parameter had a sensitivity of 61.1% (95% CI, 52.3-69.9) and specificity of 99% (95% CI, 95-100); for an assumed prevalence of 5%, the positive and negative predictive values were 75% and 98%, respectively. The positive likelihood ratio for the 6-o'clock parameter (P<5%) in early glaucoma was 61.

CONCLUSIONS

Optical coherence tomography has moderate sensitivity with high specificity for the diagnosis of early glaucoma and may have a potential role in screening.

Authors+Show Affiliations

L. V. Prasad Eye Institute, Hyderabad, India. rajulparikh@lvpei.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17561260

Citation

Parikh, Rajul S., et al. "Diagnostic Capability of Optical Coherence Tomography (Stratus OCT 3) in Early Glaucoma." Ophthalmology, vol. 114, no. 12, 2007, pp. 2238-43.
Parikh RS, Parikh S, Sekhar GC, et al. Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma. Ophthalmology. 2007;114(12):2238-43.
Parikh, R. S., Parikh, S., Sekhar, G. C., Kumar, R. S., Prabakaran, S., Babu, J. G., & Thomas, R. (2007). Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma. Ophthalmology, 114(12), 2238-43.
Parikh RS, et al. Diagnostic Capability of Optical Coherence Tomography (Stratus OCT 3) in Early Glaucoma. Ophthalmology. 2007;114(12):2238-43. PubMed PMID: 17561260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma. AU - Parikh,Rajul S, AU - Parikh,Shefali, AU - Sekhar,G Chandra, AU - Kumar,Rajesh S, AU - Prabakaran,S, AU - Babu,J Ganesh, AU - Thomas,Ravi, Y1 - 2007/06/11/ PY - 2006/09/08/received PY - 2007/03/02/revised PY - 2007/03/02/accepted PY - 2007/6/15/pubmed PY - 2007/12/19/medline PY - 2007/6/15/entrez SP - 2238 EP - 43 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 12 N2 - PURPOSE: To evaluate the diagnostic capability of optical coherence tomography (Stratus OCT 3) for early glaucoma in Asian Indian eyes. DESIGN: Cross-sectional observational study. PARTICIPANTS: Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early glaucoma was diagnosed in presence of open angles, characteristic glaucomatous optic disc changes correlating with the visual field on automated perimetry (visual field defect fulfilling at least 2 of Anderson and Patella's 3 criteria with mean deviation > or = -6 dB). Normals had visual acuity > or =20/30, intraocular pressure <22 mmHg with normal optic disc and fields and no ocular abnormality. METHODS: All patients underwent complete ophthalmic evaluation including visual field examination (24-2/30-2 SITA standard program) and imaging with Stratus OCT 3. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive and negative predictive values, area under the receiving operating characteristic curve and likelihood ratios were calculated for various Stratus OCT 3 parameters. RESULTS: Seventy-two eyes (72 patients) with early glaucoma and 96 eyes (96 normal subjects) were analyzed. The inferior maximum parameter had the best combination of sensitivity and specificity, 75% (95% confidence interval [CI], 70.2-79.8%) and 89.6% (95% CI, 82.6-96.6%), respectively. The 6-o'clock parameter had a sensitivity of 61.1% (95% CI, 52.3-69.9) and specificity of 99% (95% CI, 95-100); for an assumed prevalence of 5%, the positive and negative predictive values were 75% and 98%, respectively. The positive likelihood ratio for the 6-o'clock parameter (P<5%) in early glaucoma was 61. CONCLUSIONS: Optical coherence tomography has moderate sensitivity with high specificity for the diagnosis of early glaucoma and may have a potential role in screening. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17561260/Diagnostic_capability_of_optical_coherence_tomography__Stratus_OCT_3__in_early_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00230-8 DB - PRIME DP - Unbound Medicine ER -