Tags

Type your tag names separated by a space and hit enter

Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy.
Auton Neurosci. 2007 Oct 30; 136(1-2):90-5.AN

Abstract

The study assessed HIV-related and anti-retroviral therapy-induced neuropathy in myelinated and unmyelinated nerve fibers. One hundred consecutive HIV patients were examined clinically and standard nerve conduction velocities were measured. In addition, electrically induced sympathetic skin response (SSR) was assessed in the palms and soles. The difference in delay of SSR in palms and soles (DeltaSSR) was calculated as an indirect measure of C-fiber conduction velocity. Thick fiber conduction velocities significantly decreased with age and increasing stage of the disease, whereas no effect of stage was found for DeltaSSR (p=0.6). In contrast, medication of at least one of the most known neurotoxic drugs zalcitabine, stavudine, or didanosine did not result in significantly lower conduction velocities in thick fibers (51.29+/-3.4 m/s vs. 50.86+/-3.5 m/s), but was related to an increased DeltaSSR. DeltaSSR allows an indirect measurement of C-fiber conduction velocity. In HIV this measure of unmyelinated sympathetic fibers was most sensitive to anti-viral treatment whereas conduction velocity of myelinated somatic fibers was more sensitive to disease-related neuropathy. The results suggest that HIV neuropathy preferably affects myelinated and anti-retroviral therapy unmyelinated fibers.

Authors+Show Affiliations

Academic Departments of Neurology (Aeginition Hospital), Medical School of Athens, Athens, Greece. pkokotis@med.uoa.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17561445

Citation

Kokotis, Panagiotis, et al. "Differential Sensitivity of Thick and Thin Fibers to HIV and Therapy-induced Neuropathy." Autonomic Neuroscience : Basic & Clinical, vol. 136, no. 1-2, 2007, pp. 90-5.
Kokotis P, Schmelz M, Skopelitis EE, et al. Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy. Auton Neurosci. 2007;136(1-2):90-5.
Kokotis, P., Schmelz, M., Skopelitis, E. E., Kordossis, T., & Karandreas, N. (2007). Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy. Autonomic Neuroscience : Basic & Clinical, 136(1-2), 90-5.
Kokotis P, et al. Differential Sensitivity of Thick and Thin Fibers to HIV and Therapy-induced Neuropathy. Auton Neurosci. 2007 Oct 30;136(1-2):90-5. PubMed PMID: 17561445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy. AU - Kokotis,Panagiotis, AU - Schmelz,Martin, AU - Skopelitis,Elias E, AU - Kordossis,Theodore, AU - Karandreas,Nikolaos, Y1 - 2007/06/11/ PY - 2006/09/28/received PY - 2006/12/22/revised PY - 2007/01/27/accepted PY - 2007/6/15/pubmed PY - 2007/12/8/medline PY - 2007/6/15/entrez SP - 90 EP - 5 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 136 IS - 1-2 N2 - The study assessed HIV-related and anti-retroviral therapy-induced neuropathy in myelinated and unmyelinated nerve fibers. One hundred consecutive HIV patients were examined clinically and standard nerve conduction velocities were measured. In addition, electrically induced sympathetic skin response (SSR) was assessed in the palms and soles. The difference in delay of SSR in palms and soles (DeltaSSR) was calculated as an indirect measure of C-fiber conduction velocity. Thick fiber conduction velocities significantly decreased with age and increasing stage of the disease, whereas no effect of stage was found for DeltaSSR (p=0.6). In contrast, medication of at least one of the most known neurotoxic drugs zalcitabine, stavudine, or didanosine did not result in significantly lower conduction velocities in thick fibers (51.29+/-3.4 m/s vs. 50.86+/-3.5 m/s), but was related to an increased DeltaSSR. DeltaSSR allows an indirect measurement of C-fiber conduction velocity. In HIV this measure of unmyelinated sympathetic fibers was most sensitive to anti-viral treatment whereas conduction velocity of myelinated somatic fibers was more sensitive to disease-related neuropathy. The results suggest that HIV neuropathy preferably affects myelinated and anti-retroviral therapy unmyelinated fibers. SN - 1566-0702 UR - https://www.unboundmedicine.com/medline/citation/17561445/Differential_sensitivity_of_thick_and_thin_fibers_to_HIV_and_therapy_induced_neuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(07)00041-0 DB - PRIME DP - Unbound Medicine ER -