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Prevalence, risk factors and impact on daytime sleepiness and hypertension of periodic leg movements with arousals in patients with obstructive sleep apnea.
J Clin Sleep Med. 2006 Jul 15; 2(3):281-7.JC

Abstract

STUDY OBJECTIVE

To determine the prevalence, risk factors, and impact on daytime sleepiness and hypertension of periodic leg movements of sleep (PLMS) with associated arousals in patients with obstructive sleep apnea (OSA).

METHODS

A single-center retrospective case series of 798 consecutive patients who underwent diagnostic overnight polysomnography for suspected OSA. We performed discriminant function analysis using clinical and polysomnographic variables to examine the relationship between PLMS (periodic leg movement arousal index > or =5 per hour) and potential risk factors, including OSA.

RESULTS

Mean +/- SD age was 50 +/- 12 years, body mass index 32 +/- 8 kg/m2, Epworth Sleepiness Scale (ESS) score 11 +/- 5, and apnea-hypopnea index 31 +/- 26 per hour. Sixty-eight percent were men, 30% had systemic hypertension, and 19% were smokers. Ninety-two percent had OSA (apnea-hypopnea index +/- 5); 47% had PLMS; 44% had both OSA and PLMS; and among patients with OSA, 48% had PLMS. Significant predictors of PLMS, in order of importance, were number of predisposing medical conditions, age, number of predisposing medications, obesity, and OSA. Medical conditions that significantly predicted PLMS were depression, fibromyalgia, and diabetes mellitus. The ESS score and hypertension status were no different between those with both OSA and PLMS and those with OSA alone.

CONCLUSIONS

One in 2 patients investigated for OSA has PLMS. Risk factors for PLMS include preexisting medical conditions-particularly depression, fibromyalgia, and diabetes mellitus-increasing age, predisposing medications, obesity, and OSA. The combination of OSA and PLMS results in no greater subjective daytime sleepiness or prevalence of hypertension than OSA alone.

Authors+Show Affiliations

Division of Respiratory Medicine, Department of Medicine, Amiri Hospital, Safat, Kuwait.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17561540

Citation

Al-Alawi, Alia, et al. "Prevalence, Risk Factors and Impact On Daytime Sleepiness and Hypertension of Periodic Leg Movements With Arousals in Patients With Obstructive Sleep Apnea." Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, vol. 2, no. 3, 2006, pp. 281-7.
Al-Alawi A, Mulgrew A, Tench E, et al. Prevalence, risk factors and impact on daytime sleepiness and hypertension of periodic leg movements with arousals in patients with obstructive sleep apnea. J Clin Sleep Med. 2006;2(3):281-7.
Al-Alawi, A., Mulgrew, A., Tench, E., & Ryan, C. F. (2006). Prevalence, risk factors and impact on daytime sleepiness and hypertension of periodic leg movements with arousals in patients with obstructive sleep apnea. Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 2(3), 281-7.
Al-Alawi A, et al. Prevalence, Risk Factors and Impact On Daytime Sleepiness and Hypertension of Periodic Leg Movements With Arousals in Patients With Obstructive Sleep Apnea. J Clin Sleep Med. 2006 Jul 15;2(3):281-7. PubMed PMID: 17561540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence, risk factors and impact on daytime sleepiness and hypertension of periodic leg movements with arousals in patients with obstructive sleep apnea. AU - Al-Alawi,Alia, AU - Mulgrew,Alan, AU - Tench,Elizabeth, AU - Ryan,C Frank, PY - 2007/6/15/pubmed PY - 2007/7/25/medline PY - 2007/6/15/entrez SP - 281 EP - 7 JF - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JO - J Clin Sleep Med VL - 2 IS - 3 N2 - STUDY OBJECTIVE: To determine the prevalence, risk factors, and impact on daytime sleepiness and hypertension of periodic leg movements of sleep (PLMS) with associated arousals in patients with obstructive sleep apnea (OSA). METHODS: A single-center retrospective case series of 798 consecutive patients who underwent diagnostic overnight polysomnography for suspected OSA. We performed discriminant function analysis using clinical and polysomnographic variables to examine the relationship between PLMS (periodic leg movement arousal index > or =5 per hour) and potential risk factors, including OSA. RESULTS: Mean +/- SD age was 50 +/- 12 years, body mass index 32 +/- 8 kg/m2, Epworth Sleepiness Scale (ESS) score 11 +/- 5, and apnea-hypopnea index 31 +/- 26 per hour. Sixty-eight percent were men, 30% had systemic hypertension, and 19% were smokers. Ninety-two percent had OSA (apnea-hypopnea index +/- 5); 47% had PLMS; 44% had both OSA and PLMS; and among patients with OSA, 48% had PLMS. Significant predictors of PLMS, in order of importance, were number of predisposing medical conditions, age, number of predisposing medications, obesity, and OSA. Medical conditions that significantly predicted PLMS were depression, fibromyalgia, and diabetes mellitus. The ESS score and hypertension status were no different between those with both OSA and PLMS and those with OSA alone. CONCLUSIONS: One in 2 patients investigated for OSA has PLMS. Risk factors for PLMS include preexisting medical conditions-particularly depression, fibromyalgia, and diabetes mellitus-increasing age, predisposing medications, obesity, and OSA. The combination of OSA and PLMS results in no greater subjective daytime sleepiness or prevalence of hypertension than OSA alone. SN - 1550-9389 UR - https://www.unboundmedicine.com/medline/citation/17561540/Prevalence_risk_factors_and_impact_on_daytime_sleepiness_and_hypertension_of_periodic_leg_movements_with_arousals_in_patients_with_obstructive_sleep_apnea_ L2 - http://www.diseaseinfosearch.org/result/6636 DB - PRIME DP - Unbound Medicine ER -