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Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital.
Antimicrob Agents Chemother. 2007 Aug; 51(8):3026-9.AA

Abstract

Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla(KPC-3) gene, while almost all other clones carried the bla(KPC-2) gene. This rapid dissemination of KPC outside the United States is worrisome.

Links

Publisher Full Text
ncbi.nlm.nih.gov
aac.asm.org
PMC Free PDF

Authors+Show Affiliations

Leavitt A
Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Navon-Venezia S
No affiliation info available
Chmelnitsky I
No affiliation info available
Schwaber MJ
No affiliation info available
Carmeli Y
No affiliation info available

MeSH

Anti-Bacterial AgentsBacterial ProteinsCarbapenemsHospitalsHumansIsraelKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Epidemiologybeta-Lactam Resistancebeta-Lactamases

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17562800

Clinical Trial Links

Probiotics for Eradication of Carbapenem Resistant Klebsiella Pneumonia

Citation

Leavitt, Azita, et al. "Emergence of KPC-2 and KPC-3 in Carbapenem-resistant Klebsiella Pneumoniae Strains in an Israeli Hospital." Antimicrobial Agents and Chemotherapy, vol. 51, no. 8, 2007, pp. 3026-9.
Leavitt A, Navon-Venezia S, Chmelnitsky I, et al. Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrob Agents Chemother. 2007;51(8):3026-9.
Leavitt, A., Navon-Venezia, S., Chmelnitsky, I., Schwaber, M. J., & Carmeli, Y. (2007). Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. Antimicrobial Agents and Chemotherapy, 51(8), 3026-9.
Leavitt A, et al. Emergence of KPC-2 and KPC-3 in Carbapenem-resistant Klebsiella Pneumoniae Strains in an Israeli Hospital. Antimicrob Agents Chemother. 2007;51(8):3026-9. PubMed PMID: 17562800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. AU - Leavitt,Azita, AU - Navon-Venezia,Shiri, AU - Chmelnitsky,Inna, AU - Schwaber,Mitchell J, AU - Carmeli,Yehuda, Y1 - 2007/06/11/ PY - 2007/6/15/pubmed PY - 2007/10/20/medline PY - 2007/6/15/entrez SP - 3026 EP - 9 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 51 IS - 8 N2 - Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla(KPC-3) gene, while almost all other clones carried the bla(KPC-2) gene. This rapid dissemination of KPC outside the United States is worrisome. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/17562800/Emergence_of_KPC_2_and_KPC_3_in_carbapenem_resistant_Klebsiella_pneumoniae_strains_in_an_Israeli_hospital_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=17562800 DB - PRIME DP - Unbound Medicine ER -