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Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy.
Ital J Gastroenterol 1991; 23(8 Suppl 1):60-3IJ

Abstract

Seventy-two patients complaining of abdominal pain were studied in a double blind trial with otilonium bromide (OB) (40 mg tid or placebo). In our patients we performed, before and after the treatment, a clinical evaluation (symptom variations) and functional studies (sigmoid manometry during bowel distension). As regards clinical parameters, otilonium bromide significantly reduced abdominal pain and bloating and significantly increased (p less than 0.02) the pain threshold. However the comparison with the placebo group did not show any difference between the two groups. Sigmoid motility during distension was significantly reduced (p less than 0.05) in OB group, whereas it did not change in the placebo group. We can conclude that, in irritable bowel syndrome (IBS) patients, OB is able to improve symptoms and to reduce stimulated motor activity of the sigmoid.

Authors+Show Affiliations

Divisioni di Gastroenterologia di Bologna, Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

1756285

Citation

Baldi, F, et al. "Clinical and Functional Evaluation of the Efficacy of Otilonium Bromide: a Multicenter Study in Italy." The Italian Journal of Gastroenterology, vol. 23, no. 8 Suppl 1, 1991, pp. 60-3.
Baldi F, Longanesi A, Blasi A, et al. Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy. Ital J Gastroenterol. 1991;23(8 Suppl 1):60-3.
Baldi, F., Longanesi, A., Blasi, A., Monello, S., Cestari, R., Missale, G., ... Anastasio, G. (1991). Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy. The Italian Journal of Gastroenterology, 23(8 Suppl 1), pp. 60-3.
Baldi F, et al. Clinical and Functional Evaluation of the Efficacy of Otilonium Bromide: a Multicenter Study in Italy. Ital J Gastroenterol. 1991;23(8 Suppl 1):60-3. PubMed PMID: 1756285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and functional evaluation of the efficacy of otilonium bromide: a multicenter study in Italy. A1 - Baldi,F, AU - Longanesi,A, AU - Blasi,A, AU - Monello,S, AU - Cestari,R, AU - Missale,G, AU - Corazziari,E, AU - Badiali,G, AU - Pescatori,M, AU - Anastasio,G, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 60 EP - 3 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 23 IS - 8 Suppl 1 N2 - Seventy-two patients complaining of abdominal pain were studied in a double blind trial with otilonium bromide (OB) (40 mg tid or placebo). In our patients we performed, before and after the treatment, a clinical evaluation (symptom variations) and functional studies (sigmoid manometry during bowel distension). As regards clinical parameters, otilonium bromide significantly reduced abdominal pain and bloating and significantly increased (p less than 0.02) the pain threshold. However the comparison with the placebo group did not show any difference between the two groups. Sigmoid motility during distension was significantly reduced (p less than 0.05) in OB group, whereas it did not change in the placebo group. We can conclude that, in irritable bowel syndrome (IBS) patients, OB is able to improve symptoms and to reduce stimulated motor activity of the sigmoid. SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/1756285/Clinical_and_functional_evaluation_of_the_efficacy_of_otilonium_bromide:_a_multicenter_study_in_Italy_ L2 - https://medlineplus.gov/irritablebowelsyndrome.html DB - PRIME DP - Unbound Medicine ER -