Genetics of Parkinson's disease and parkinsonism.Expert Rev Neurother. 2007 Jun; 7(6):657-66.ER
Abstract
The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.
Links
MeSH
BrainClinical Trials as TopicGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenetic TherapyHumansIntracellular Signaling Peptides and ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Oncogene ProteinsParkinson DiseaseProtein Deglycase DJ-1Protein KinasesProtein Serine-Threonine KinasesUbiquitin-Protein Ligasesalpha-Synuclein
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
17563249
Citation
Douglas, Michael R., et al. "Genetics of Parkinson's Disease and Parkinsonism." Expert Review of Neurotherapeutics, vol. 7, no. 6, 2007, pp. 657-66.
Douglas MR, Lewthwaite AJ, Nicholl DJ. Genetics of Parkinson's disease and parkinsonism. Expert Rev Neurother. 2007;7(6):657-66.
Douglas, M. R., Lewthwaite, A. J., & Nicholl, D. J. (2007). Genetics of Parkinson's disease and parkinsonism. Expert Review of Neurotherapeutics, 7(6), 657-66.
Douglas MR, Lewthwaite AJ, Nicholl DJ. Genetics of Parkinson's Disease and Parkinsonism. Expert Rev Neurother. 2007;7(6):657-66. PubMed PMID: 17563249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Genetics of Parkinson's disease and parkinsonism.
AU - Douglas,Michael R,
AU - Lewthwaite,Alistair J,
AU - Nicholl,David J,
PY - 2007/6/15/pubmed
PY - 2007/7/4/medline
PY - 2007/6/15/entrez
SP - 657
EP - 66
JF - Expert review of neurotherapeutics
JO - Expert Rev Neurother
VL - 7
IS - 6
N2 - The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.
SN - 1744-8360
UR - https://www.unboundmedicine.com/medline/citation/17563249/Genetics_of_Parkinson's_disease_and_parkinsonism_
L2 - https://www.tandfonline.com/doi/full/10.1586/14737175.7.6.657
DB - PRIME
DP - Unbound Medicine
ER -