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Genetics of Parkinson's disease and parkinsonism.
Expert Rev Neurother. 2007 Jun; 7(6):657-66.ER

Abstract

The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease.

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Authors+Show Affiliations

Douglas MR
University of Birmingham Medical School, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK. m.r.douglas@blueyonder.co.uk
Lewthwaite AJ
No affiliation info available
Nicholl DJ
No affiliation info available

MeSH

BrainClinical Trials as TopicGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenetic TherapyHumansIntracellular Signaling Peptides and ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Oncogene ProteinsParkinson DiseaseProtein Deglycase DJ-1Protein KinasesProtein Serine-Threonine KinasesUbiquitin-Protein Ligasesalpha-Synuclein

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17563249

Citation

Douglas, Michael R., et al. "Genetics of Parkinson's Disease and Parkinsonism." Expert Review of Neurotherapeutics, vol. 7, no. 6, 2007, pp. 657-66.
Douglas MR, Lewthwaite AJ, Nicholl DJ. Genetics of Parkinson's disease and parkinsonism. Expert Rev Neurother. 2007;7(6):657-66.
Douglas, M. R., Lewthwaite, A. J., & Nicholl, D. J. (2007). Genetics of Parkinson's disease and parkinsonism. Expert Review of Neurotherapeutics, 7(6), 657-66.
Douglas MR, Lewthwaite AJ, Nicholl DJ. Genetics of Parkinson's Disease and Parkinsonism. Expert Rev Neurother. 2007;7(6):657-66. PubMed PMID: 17563249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics of Parkinson's disease and parkinsonism. AU - Douglas,Michael R, AU - Lewthwaite,Alistair J, AU - Nicholl,David J, PY - 2007/6/15/pubmed PY - 2007/7/4/medline PY - 2007/6/15/entrez SP - 657 EP - 66 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 7 IS - 6 N2 - The past 10 years has seen a shift in our etiological concepts of Parkinson's disease, moving from a nearly exclusively environmentally mediated disease towards a complex disorder with important genetic contributors. The identification of responsible mutations in certain genes, particularly alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, has increased our understanding of the clinical and pathological changes underlying Parkinson's disease, with implications for patient diagnosis, management and future research. This review will outline the specific genetic advances, discuss their implications for clinical practice and hint at future directions for research into this common and disabling disease. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/17563249/Genetics_of_Parkinson's_disease_and_parkinsonism_ L2 - https://www.tandfonline.com/doi/full/10.1586/14737175.7.6.657 DB - PRIME DP - Unbound Medicine ER -