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Effect of oesophagitis on proximal extent of gastro-oesophageal reflux.
Neurogastroenterol Motil 2007; 19(6):459-64NM

Abstract

Proximal oesophageal acid reflux is increased in gastro-oesophageal reflux disease (GORD) patients with oesophageal and extra-oesophageal symptoms, the latter particularly in presence of oesophagitis. This study was aimed to assess the proximal extent of reflux, both acid and weakly acidic, in GORD patients with and without oesophagitis and to characterize, using an animal model of GORD, the relationship between acute oesophagitis and proximal extent of reflux. Proximal extent of reflux was evaluated during 24-h pH-impedance monitoring in 17 oesophagitis, 27 non-erosive reflux disease (NERD) patients and 10 asymptomatic controls. In five adult cats, reflux events were simulated by intra-oesophageal retrograde injection of a radiopaque solution. Proximal extent of simulated reflux was fluoroscopically assessed before and after inducing acute oesophagitis. The percentage of proximal reflux was 11% in controls, 22% in NERD and 38% in oesophagitis patients (P < 0.05 vs NERD). Weakly acidic reflux showed higher proximal extent in oesophagitis than in NERD patients but it was less proximally propagated than acid reflux. In cats, proximal reflux was significantly increased during acute oesophagitis. Oesophagitis patients show higher proximal extent of reflux, acid and weakly acidic, when compared with NERD patients and controls. In the experimental model, acute oesophagitis favours proximal migration of simulated reflux.

Authors+Show Affiliations

Department of Digestive Disease, University Campus Bio Medico, Rome, Italy. s.emerenziani@unicampus.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17564627

Citation

Emerenziani, S, et al. "Effect of Oesophagitis On Proximal Extent of Gastro-oesophageal Reflux." Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, vol. 19, no. 6, 2007, pp. 459-64.
Emerenziani S, Cicala M, Zhang X, et al. Effect of oesophagitis on proximal extent of gastro-oesophageal reflux. Neurogastroenterol Motil. 2007;19(6):459-64.
Emerenziani, S., Cicala, M., Zhang, X., Ribolsi, M., Caviglia, R., Guarino, M. P., & Sifrim, D. (2007). Effect of oesophagitis on proximal extent of gastro-oesophageal reflux. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society, 19(6), pp. 459-64.
Emerenziani S, et al. Effect of Oesophagitis On Proximal Extent of Gastro-oesophageal Reflux. Neurogastroenterol Motil. 2007;19(6):459-64. PubMed PMID: 17564627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oesophagitis on proximal extent of gastro-oesophageal reflux. AU - Emerenziani,S, AU - Cicala,M, AU - Zhang,X, AU - Ribolsi,M, AU - Caviglia,R, AU - Guarino,M P L, AU - Sifrim,D, PY - 2007/6/15/pubmed PY - 2007/7/17/medline PY - 2007/6/15/entrez SP - 459 EP - 64 JF - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society JO - Neurogastroenterol. Motil. VL - 19 IS - 6 N2 - Proximal oesophageal acid reflux is increased in gastro-oesophageal reflux disease (GORD) patients with oesophageal and extra-oesophageal symptoms, the latter particularly in presence of oesophagitis. This study was aimed to assess the proximal extent of reflux, both acid and weakly acidic, in GORD patients with and without oesophagitis and to characterize, using an animal model of GORD, the relationship between acute oesophagitis and proximal extent of reflux. Proximal extent of reflux was evaluated during 24-h pH-impedance monitoring in 17 oesophagitis, 27 non-erosive reflux disease (NERD) patients and 10 asymptomatic controls. In five adult cats, reflux events were simulated by intra-oesophageal retrograde injection of a radiopaque solution. Proximal extent of simulated reflux was fluoroscopically assessed before and after inducing acute oesophagitis. The percentage of proximal reflux was 11% in controls, 22% in NERD and 38% in oesophagitis patients (P < 0.05 vs NERD). Weakly acidic reflux showed higher proximal extent in oesophagitis than in NERD patients but it was less proximally propagated than acid reflux. In cats, proximal reflux was significantly increased during acute oesophagitis. Oesophagitis patients show higher proximal extent of reflux, acid and weakly acidic, when compared with NERD patients and controls. In the experimental model, acute oesophagitis favours proximal migration of simulated reflux. SN - 1350-1925 UR - https://www.unboundmedicine.com/medline/citation/17564627/Effect_of_oesophagitis_on_proximal_extent_of_gastro_oesophageal_reflux_ L2 - https://doi.org/10.1111/j.1365-2982.2006.00868.x DB - PRIME DP - Unbound Medicine ER -