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Evaluation of the developmental toxicity of alpha-iso-methylionone in rats.
Int J Toxicol. 2007 May-Jun; 26(3):271-6.IJ

Abstract

Alpha-iso-methylionone, a widely used fragrance ingredient, was evaluated for developmental toxicity in presumed pregnant Sprague-Dawley rats (25/group). Oral dosages of 0, 3, 10, or 30 mg/kg/day alpha-iso-methylionone in corn oil were administered by gavage on gestational days 7 to 17. The presence of spermatozoa and/or a copulatory plug in situ was designated as gestational day. Rats were observed for viability, clinical signs, body weights, and feed consumption. Caesarean sectioning and necropsy occurred on gestational day 21. Uteri were examined for number and distribution of implantations, live and dead fetuses, and early and late resorptions. Numbers of corpora lutea were also recorded. Fetuses were weighed and examined for gender, gross external changes, and soft tissue or skeletal alterations. No maternal or fetal deaths occurred. No fragrance ingredient-related clinical signs were observed. Feed consumption, body weight gains, gross tissue changes at necropsy, and caesarean section or litter parameters, as well as fetal developmental morphology, were unaffected by dosages of alpha-iso-methylionone as high as 30 mg/kg/day. Based on these data, maternal and developmental no observed adverse effect levels of equal to or greater than 30 mg/kg/day were established for alpha-iso-methylionone. It is concluded that alpha-iso-methylionone is not a developmental toxicant in rats at maternal doses of up to 30 mg/kg/day.

Authors+Show Affiliations

Research Institute for Fragrance Materials, Inc., Woodcliff Lake, New Jersey 07677, USA. vpolitano@rifm.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17564909

Citation

Politano, Valerie T., et al. "Evaluation of the Developmental Toxicity of Alpha-iso-methylionone in Rats." International Journal of Toxicology, vol. 26, no. 3, 2007, pp. 271-6.
Politano VT, Lewis EM, Hoberman AM, et al. Evaluation of the developmental toxicity of alpha-iso-methylionone in rats. Int J Toxicol. 2007;26(3):271-6.
Politano, V. T., Lewis, E. M., Hoberman, A. M., Christian, M. S., Diener, R. M., & Api, A. M. (2007). Evaluation of the developmental toxicity of alpha-iso-methylionone in rats. International Journal of Toxicology, 26(3), 271-6.
Politano VT, et al. Evaluation of the Developmental Toxicity of Alpha-iso-methylionone in Rats. Int J Toxicol. 2007 May-Jun;26(3):271-6. PubMed PMID: 17564909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the developmental toxicity of alpha-iso-methylionone in rats. AU - Politano,Valerie T, AU - Lewis,Elise M, AU - Hoberman,Alan M, AU - Christian,Mildred S, AU - Diener,Robert M, AU - Api,Anne Marie, PY - 2007/6/15/pubmed PY - 2007/12/27/medline PY - 2007/6/15/entrez SP - 271 EP - 6 JF - International journal of toxicology JO - Int J Toxicol VL - 26 IS - 3 N2 - Alpha-iso-methylionone, a widely used fragrance ingredient, was evaluated for developmental toxicity in presumed pregnant Sprague-Dawley rats (25/group). Oral dosages of 0, 3, 10, or 30 mg/kg/day alpha-iso-methylionone in corn oil were administered by gavage on gestational days 7 to 17. The presence of spermatozoa and/or a copulatory plug in situ was designated as gestational day. Rats were observed for viability, clinical signs, body weights, and feed consumption. Caesarean sectioning and necropsy occurred on gestational day 21. Uteri were examined for number and distribution of implantations, live and dead fetuses, and early and late resorptions. Numbers of corpora lutea were also recorded. Fetuses were weighed and examined for gender, gross external changes, and soft tissue or skeletal alterations. No maternal or fetal deaths occurred. No fragrance ingredient-related clinical signs were observed. Feed consumption, body weight gains, gross tissue changes at necropsy, and caesarean section or litter parameters, as well as fetal developmental morphology, were unaffected by dosages of alpha-iso-methylionone as high as 30 mg/kg/day. Based on these data, maternal and developmental no observed adverse effect levels of equal to or greater than 30 mg/kg/day were established for alpha-iso-methylionone. It is concluded that alpha-iso-methylionone is not a developmental toxicant in rats at maternal doses of up to 30 mg/kg/day. SN - 1091-5818 UR - https://www.unboundmedicine.com/medline/citation/17564909/Evaluation_of_the_developmental_toxicity_of_alpha_iso_methylionone_in_rats_ DB - PRIME DP - Unbound Medicine ER -