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Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis.
Am J Perinatol. 2007 Jun; 24(6):331-8.AJ

Abstract

Adhesion molecules may play a role in the evolution and severity of neonatal sepsis. The purposes of this study were to determine whether serum soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, L-selectin, and P-selectin levels are useful tools in the diagnosis of proven sepsis in newborn infants, and whether their levels are related to the clinical severity of the disease. A cohort of 25 consecutive newborns meeting criteria for clinical sepsis, 10 hemoculture-negative (HC -) and 15 hemoculture-positive (HC +), were prospectively followed and compared with 12 healthy newborns (six </= 38 weeks of gestational age and six >/= 39 weeks). Serum soluble (s)ICAM-1, sVCAM-1, sL-selectin, and sP-selectin concentrations were measured at the time of the septic workup, then followed by up to three determinations in each newborn every third day. The Score for Neonatal Acute Physiology (SNAP)-II severity was assessed at the moment of highest clinical severity of the disease. At the beginning of sepsis, sICAM-1 levels increased in both groups, being higher in HC + sepsis than in HC - ; sVCAM-1 only increased slightly in HC + sepsis. Soluble ICAM-1 levels were independently related to group of sepsis, and not to days of life. The best initial sICAM-1 cutoff level for diagnosing HC + neonatal sepsis was 274 microg/L. The highest sICAM-1 levels were positively correlated with SNAP-II scores. Soluble L-selectin and sP-selectin did not change. Soluble ICAM-1 levels increased in HC - and HC + sepsis, but concentrations > 274 microg/L suggest HC + sepsis. These levels were related to the clinical severity of the disease. Soluble VCAM-1 levels increased only slightly in HC + sepsis. Soluble L-selectin and sP-selectin did not change.

Authors+Show Affiliations

Servicio Neonatología, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17564956

Citation

Figueras-Aloy, José, et al. "Serum Soluble ICAM-1, VCAM-1, L-selectin, and P-selectin Levels as Markers of Infection and Their Relation to Clinical Severity in Neonatal Sepsis." American Journal of Perinatology, vol. 24, no. 6, 2007, pp. 331-8.
Figueras-Aloy J, Gómez-López L, Rodríguez-Miguélez JM, et al. Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis. Am J Perinatol. 2007;24(6):331-8.
Figueras-Aloy, J., Gómez-López, L., Rodríguez-Miguélez, J. M., Salvia-Roiges, M. D., Jordán-García, I., Ferrer-Codina, I., Carbonell-Estrany, X., & Jiménez-González, R. (2007). Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis. American Journal of Perinatology, 24(6), 331-8.
Figueras-Aloy J, et al. Serum Soluble ICAM-1, VCAM-1, L-selectin, and P-selectin Levels as Markers of Infection and Their Relation to Clinical Severity in Neonatal Sepsis. Am J Perinatol. 2007;24(6):331-8. PubMed PMID: 17564956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis. AU - Figueras-Aloy,José, AU - Gómez-López,Lilian, AU - Rodríguez-Miguélez,José-Manuel, AU - Salvia-Roiges,M Dolors, AU - Jordán-García,Iolanda, AU - Ferrer-Codina,Inmaculada, AU - Carbonell-Estrany,Xavier, AU - Jiménez-González,Rafael, Y1 - 2007/06/12/ PY - 2007/6/15/pubmed PY - 2007/8/25/medline PY - 2007/6/15/entrez SP - 331 EP - 8 JF - American journal of perinatology JO - Am J Perinatol VL - 24 IS - 6 N2 - Adhesion molecules may play a role in the evolution and severity of neonatal sepsis. The purposes of this study were to determine whether serum soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, L-selectin, and P-selectin levels are useful tools in the diagnosis of proven sepsis in newborn infants, and whether their levels are related to the clinical severity of the disease. A cohort of 25 consecutive newborns meeting criteria for clinical sepsis, 10 hemoculture-negative (HC -) and 15 hemoculture-positive (HC +), were prospectively followed and compared with 12 healthy newborns (six </= 38 weeks of gestational age and six >/= 39 weeks). Serum soluble (s)ICAM-1, sVCAM-1, sL-selectin, and sP-selectin concentrations were measured at the time of the septic workup, then followed by up to three determinations in each newborn every third day. The Score for Neonatal Acute Physiology (SNAP)-II severity was assessed at the moment of highest clinical severity of the disease. At the beginning of sepsis, sICAM-1 levels increased in both groups, being higher in HC + sepsis than in HC - ; sVCAM-1 only increased slightly in HC + sepsis. Soluble ICAM-1 levels were independently related to group of sepsis, and not to days of life. The best initial sICAM-1 cutoff level for diagnosing HC + neonatal sepsis was 274 microg/L. The highest sICAM-1 levels were positively correlated with SNAP-II scores. Soluble L-selectin and sP-selectin did not change. Soluble ICAM-1 levels increased in HC - and HC + sepsis, but concentrations > 274 microg/L suggest HC + sepsis. These levels were related to the clinical severity of the disease. Soluble VCAM-1 levels increased only slightly in HC + sepsis. Soluble L-selectin and sP-selectin did not change. SN - 0735-1631 UR - https://www.unboundmedicine.com/medline/citation/17564956/Serum_soluble_ICAM_1_VCAM_1_L_selectin_and_P_selectin_levels_as_markers_of_infection_and_their_relation_to_clinical_severity_in_neonatal_sepsis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-981851 DB - PRIME DP - Unbound Medicine ER -