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Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index.
J Zhejiang Univ Sci B. 2007 Jun; 8(6):428-34.JZ

Abstract

OBJECTIVE

To compare the effects of epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine on propofol requirements, the time to loss of consciousness (LOC), effect-site propofol concentrations, and the hemodynamic variables during induction of general anesthesia guided by bispectral index (BIS) were studied.

METHODS

Forty-five patients were divided into three groups to receive epidurally administered saline (Group S), 1.5% (w/w) lidocaine (Group L), or 0.5% (w/w) ropivacaine (Group R). Propofol infusion was started to produce blood concentration of 4 mug/ml. Once the BIS value reached 40~50, endotracheal intubation was facilitated by 0.1 mg/kg vecuronium. Measurements included the time to LOC, effect-site propofol concentrations, total propofol dose, mean arterial blood pressure (MABP), and heart rate (HR) at different study time points.

RESULTS

During induction of anesthesia, both Groups L and R were similar for the time to LOC, effect-site propofol concentrations, total propofol dose, MABP, HR, and BIS. The total doses of propofol administered until 1 min post-intubation were significantly less in patients of Groups R and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or MABP was significantly increased following intubation as compared with that prior to intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups.

CONCLUSION

Epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine has similar effects on the time to LOC, effect-site propofol concentrations, total propofol dose, and the hemodynamic variables during induction of general anesthesia.

Authors+Show Affiliations

Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17565514

Citation

Xiang, Yan, and Yu-Hong Li. "Comparison of 1.5% Lidocaine and 0.5% Ropivacaine Epidural Anesthesia Combined With Propofol General Anesthesia Guided By Bispectral Index." Journal of Zhejiang University. Science. B, vol. 8, no. 6, 2007, pp. 428-34.
Xiang Y, Li YH. Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index. J Zhejiang Univ Sci B. 2007;8(6):428-34.
Xiang, Y., & Li, Y. H. (2007). Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index. Journal of Zhejiang University. Science. B, 8(6), 428-34.
Xiang Y, Li YH. Comparison of 1.5% Lidocaine and 0.5% Ropivacaine Epidural Anesthesia Combined With Propofol General Anesthesia Guided By Bispectral Index. J Zhejiang Univ Sci B. 2007;8(6):428-34. PubMed PMID: 17565514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of 1.5% lidocaine and 0.5% ropivacaine epidural anesthesia combined with propofol general anesthesia guided by bispectral index. AU - Xiang,Yan, AU - Li,Yu-Hong, PY - 2007/6/15/pubmed PY - 2007/7/21/medline PY - 2007/6/15/entrez SP - 428 EP - 34 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 8 IS - 6 N2 - OBJECTIVE: To compare the effects of epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine on propofol requirements, the time to loss of consciousness (LOC), effect-site propofol concentrations, and the hemodynamic variables during induction of general anesthesia guided by bispectral index (BIS) were studied. METHODS: Forty-five patients were divided into three groups to receive epidurally administered saline (Group S), 1.5% (w/w) lidocaine (Group L), or 0.5% (w/w) ropivacaine (Group R). Propofol infusion was started to produce blood concentration of 4 mug/ml. Once the BIS value reached 40~50, endotracheal intubation was facilitated by 0.1 mg/kg vecuronium. Measurements included the time to LOC, effect-site propofol concentrations, total propofol dose, mean arterial blood pressure (MABP), and heart rate (HR) at different study time points. RESULTS: During induction of anesthesia, both Groups L and R were similar for the time to LOC, effect-site propofol concentrations, total propofol dose, MABP, HR, and BIS. The total doses of propofol administered until 1 min post-intubation were significantly less in patients of Groups R and L compared with Group S. MABP and HR were significantly lower following propofol induction compared with baseline values in the three groups, or MABP was significantly increased following intubation as compared with that prior to intubation in Group S but not in Groups R and L while HR was significantly increased following intubation in the three groups. CONCLUSION: Epidural anesthesia with 1.5% lidocaine and 0.5% ropivacaine has similar effects on the time to LOC, effect-site propofol concentrations, total propofol dose, and the hemodynamic variables during induction of general anesthesia. SN - 1673-1581 UR - https://www.unboundmedicine.com/medline/citation/17565514/Comparison_of_1_5_lidocaine_and_0_5_ropivacaine_epidural_anesthesia_combined_with_propofol_general_anesthesia_guided_by_bispectral_index_ L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.2007.B0428 DB - PRIME DP - Unbound Medicine ER -