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Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease.
BMC Neurol 2007; 7:14BN

Abstract

BACKGROUND

Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects.

METHODS

We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia.

RESULTS

We demonstrated an elevated level of fibrinogen gamma-A chain precursor protein in CSF from patients with mild cognitive impairment and AD compared to the age-matched normal subjects. Moreover, its expression was more prominent in the AD group than in the MCI and correlated with disease severity and progression. In contrast, fibrinogen gamma-A chain precursor protein was detected very low in the age-matched normal group.

CONCLUSION

These findings suggest that the CSF level of fibrinogen gamma-A chain precursor may be a candidate biomarker for AD.

Authors+Show Affiliations

Department of Neurology, Bobath Memorial Hospital, Bundang-Gu, Seongnam, Gyungki-do, Korea. marineultrablue@yahoo.co.kr <marineultrablue@yahoo.co.kr>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17565664

Citation

Lee, Joung Wook, et al. "Fibrinogen gamma-A Chain Precursor in CSF: a Candidate Biomarker for Alzheimer's Disease." BMC Neurology, vol. 7, 2007, p. 14.
Lee JW, Namkoong H, Kim HK, et al. Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease. BMC Neurol. 2007;7:14.
Lee, J. W., Namkoong, H., Kim, H. K., Kim, S., Hwang, D. W., Na, H. R., ... Kim, J. W. (2007). Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease. BMC Neurology, 7, p. 14.
Lee JW, et al. Fibrinogen gamma-A Chain Precursor in CSF: a Candidate Biomarker for Alzheimer's Disease. BMC Neurol. 2007 Jun 12;7:14. PubMed PMID: 17565664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease. AU - Lee,Joung Wook, AU - Namkoong,Hong, AU - Kim,Hyun Kee, AU - Kim,Sanghee, AU - Hwang,Dong Whi, AU - Na,Hae Ri, AU - Ha,Seon-Ah, AU - Kim,Jae-Ryong, AU - Kim,Jin Woo, Y1 - 2007/06/12/ PY - 2006/09/15/received PY - 2007/06/12/accepted PY - 2007/6/15/pubmed PY - 2007/7/18/medline PY - 2007/6/15/entrez SP - 14 EP - 14 JF - BMC neurology JO - BMC Neurol VL - 7 N2 - BACKGROUND: Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects. METHODS: We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia. RESULTS: We demonstrated an elevated level of fibrinogen gamma-A chain precursor protein in CSF from patients with mild cognitive impairment and AD compared to the age-matched normal subjects. Moreover, its expression was more prominent in the AD group than in the MCI and correlated with disease severity and progression. In contrast, fibrinogen gamma-A chain precursor protein was detected very low in the age-matched normal group. CONCLUSION: These findings suggest that the CSF level of fibrinogen gamma-A chain precursor may be a candidate biomarker for AD. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/17565664/Fibrinogen_gamma_A_chain_precursor_in_CSF:_a_candidate_biomarker_for_Alzheimer's_disease_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-7-14 DB - PRIME DP - Unbound Medicine ER -