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Genetic epidemiology of obesity.
Epidemiol Rev 2007; 29:49-61ER

Abstract

Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, stroke, some types of cancer, and premature death worldwide. Obesity is highly heritable and arises from the interactions of multiple genes, environmental factors, and behavior. In this paper, the authors reviewed recent developments in genetic epidemiologic research, focusing particularly on several promising genomic regions and obesity-related genes. Gene-gene and gene-environment interactions of obesity were also discussed. Published studies were accessed through the MEDLINE database. The authors also searched the Obesity Gene Map Database (http://obesitygene.pbrc.edu/) and conducted a manual search using references cited in relevant papers. Heritabilities for obesity-related phenotypes varied from 6% to 85% among various populations. As of October 2005, 253 quantitative trait loci for obesity-related phenotypes have been localized in 61 genome-wide linkage scans, and genetic variants in 127 biologic candidate genes have been reported to be associated with obesity-related phenotypes from 426 positive findings. Gene-gene interactions were also observed in several genes, and some genes were found to influence the effect of dietary intake and physical activity on obesity-related phenotypes. Integration of genetic epidemiology with functional genomics and proteomics studies will be required to fully understand the role of genetic variants in the etiology and prevention of obesity.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17566051

Citation

Yang, Wenjie, et al. "Genetic Epidemiology of Obesity." Epidemiologic Reviews, vol. 29, 2007, pp. 49-61.
Yang W, Kelly T, He J. Genetic epidemiology of obesity. Epidemiol Rev. 2007;29:49-61.
Yang, W., Kelly, T., & He, J. (2007). Genetic epidemiology of obesity. Epidemiologic Reviews, 29, pp. 49-61.
Yang W, Kelly T, He J. Genetic Epidemiology of Obesity. Epidemiol Rev. 2007;29:49-61. PubMed PMID: 17566051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic epidemiology of obesity. AU - Yang,Wenjie, AU - Kelly,Tanika, AU - He,Jiang, Y1 - 2007/06/12/ PY - 2007/6/15/pubmed PY - 2007/10/27/medline PY - 2007/6/15/entrez SP - 49 EP - 61 JF - Epidemiologic reviews JO - Epidemiol Rev VL - 29 N2 - Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, stroke, some types of cancer, and premature death worldwide. Obesity is highly heritable and arises from the interactions of multiple genes, environmental factors, and behavior. In this paper, the authors reviewed recent developments in genetic epidemiologic research, focusing particularly on several promising genomic regions and obesity-related genes. Gene-gene and gene-environment interactions of obesity were also discussed. Published studies were accessed through the MEDLINE database. The authors also searched the Obesity Gene Map Database (http://obesitygene.pbrc.edu/) and conducted a manual search using references cited in relevant papers. Heritabilities for obesity-related phenotypes varied from 6% to 85% among various populations. As of October 2005, 253 quantitative trait loci for obesity-related phenotypes have been localized in 61 genome-wide linkage scans, and genetic variants in 127 biologic candidate genes have been reported to be associated with obesity-related phenotypes from 426 positive findings. Gene-gene interactions were also observed in several genes, and some genes were found to influence the effect of dietary intake and physical activity on obesity-related phenotypes. Integration of genetic epidemiology with functional genomics and proteomics studies will be required to fully understand the role of genetic variants in the etiology and prevention of obesity. SN - 0193-936X UR - https://www.unboundmedicine.com/medline/citation/17566051/Genetic_epidemiology_of_obesity_ L2 - https://academic.oup.com/epirev/article-lookup/doi/10.1093/epirev/mxm004 DB - PRIME DP - Unbound Medicine ER -