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Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study.
Eur J Cardiovasc Prev Rehabil. 2007 Jun; 14(3):392-7.EJ

Abstract

BACKGROUND

Complement factor C3 and C4 have been associated with atherosclerosis and cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk factors for the incidence of cardiovascular disease (CVD).

DESIGN

A population-based prospective study of 5850 initially healthy men, 28-61 years old at baseline.

METHODS

Plasma levels of C3 and C4 were analysed at the baseline examination. The incidence of coronary events (i.e. fatal or non-fatal myocardial infarction), ischaemic stroke and cardiovascular events (i.e. myocardial infarction, ischaemic stroke or cardiovascular death) was studied over 18 years of follow-up.

RESULTS

Adjusted for age, C3 in the fourth quartile (versus the first quartile) was associated with an increased incidence of coronary events [relative risk (RR) 1.54, 95% confidence interval (CI) 1.2-1.9], cardiovascular events (RR 1.56, 95% CI 1.3-1.9), and non-significantly with the incidence of ischaemic stroke (RR 1.31, 95% CI 0.89-1.8). However, after adjustments for smoking, body mass index (BMI), cholesterol, diabetes and systolic blood pressure, these relationships were completely attenuated and non-significant. The relationships were similar for C4 concentrations within the normal range. However, for men with C4 in the top 10% of the distribution (>0.34 g/l), a significantly increased incidence of coronary events was found, which persisted after adjustments for risk factors.

CONCLUSION

C3 and C4 show substantial correlations with cardiovascular risk factors, including blood pressure, BMI, and lipids. This relationship accounts for the increased incidence of CVD in men with high C3 levels. However, very high C4 levels may be associated with the incidence of CVD, independently of traditional cardiovascular risk factors.

Authors+Show Affiliations

Lund University, Department of Clinical Science, Malmö University Hospital, Malmö, Sweden. gunnar.engstrom@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17568238

Citation

Engström, Gunnar, et al. "Complement C3 and C4 in Plasma and Incidence of Myocardial Infarction and Stroke: a Population-based Cohort Study." European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, vol. 14, no. 3, 2007, pp. 392-7.
Engström G, Hedblad B, Janzon L, et al. Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. Eur J Cardiovasc Prev Rehabil. 2007;14(3):392-7.
Engström, G., Hedblad, B., Janzon, L., & Lindgärde, F. (2007). Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups On Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 14(3), 392-7.
Engström G, et al. Complement C3 and C4 in Plasma and Incidence of Myocardial Infarction and Stroke: a Population-based Cohort Study. Eur J Cardiovasc Prev Rehabil. 2007;14(3):392-7. PubMed PMID: 17568238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. AU - Engström,Gunnar, AU - Hedblad,Bo, AU - Janzon,Lars, AU - Lindgärde,Folke, PY - 2007/6/15/pubmed PY - 2007/8/3/medline PY - 2007/6/15/entrez SP - 392 EP - 7 JF - European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology JO - Eur J Cardiovasc Prev Rehabil VL - 14 IS - 3 N2 - BACKGROUND: Complement factor C3 and C4 have been associated with atherosclerosis and cardiovascular risk factors. This study explored whether plasma levels of C3 and C4 are risk factors for the incidence of cardiovascular disease (CVD). DESIGN: A population-based prospective study of 5850 initially healthy men, 28-61 years old at baseline. METHODS: Plasma levels of C3 and C4 were analysed at the baseline examination. The incidence of coronary events (i.e. fatal or non-fatal myocardial infarction), ischaemic stroke and cardiovascular events (i.e. myocardial infarction, ischaemic stroke or cardiovascular death) was studied over 18 years of follow-up. RESULTS: Adjusted for age, C3 in the fourth quartile (versus the first quartile) was associated with an increased incidence of coronary events [relative risk (RR) 1.54, 95% confidence interval (CI) 1.2-1.9], cardiovascular events (RR 1.56, 95% CI 1.3-1.9), and non-significantly with the incidence of ischaemic stroke (RR 1.31, 95% CI 0.89-1.8). However, after adjustments for smoking, body mass index (BMI), cholesterol, diabetes and systolic blood pressure, these relationships were completely attenuated and non-significant. The relationships were similar for C4 concentrations within the normal range. However, for men with C4 in the top 10% of the distribution (>0.34 g/l), a significantly increased incidence of coronary events was found, which persisted after adjustments for risk factors. CONCLUSION: C3 and C4 show substantial correlations with cardiovascular risk factors, including blood pressure, BMI, and lipids. This relationship accounts for the increased incidence of CVD in men with high C3 levels. However, very high C4 levels may be associated with the incidence of CVD, independently of traditional cardiovascular risk factors. SN - 1741-8267 UR - https://www.unboundmedicine.com/medline/citation/17568238/Complement_C3_and_C4_in_plasma_and_incidence_of_myocardial_infarction_and_stroke:_a_population_based_cohort_study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17568238.ui DB - PRIME DP - Unbound Medicine ER -