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Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.
Clin Pharmacol Ther. 2008 Feb; 83(2):251-7.CP

Abstract

This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations.

Authors+Show Affiliations

Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17568401

Citation

Choi, J H., et al. "Influence of OATP1B1 Genotype On the Pharmacokinetics of Rosuvastatin in Koreans." Clinical Pharmacology and Therapeutics, vol. 83, no. 2, 2008, pp. 251-7.
Choi JH, Lee MG, Cho JY, et al. Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. Clin Pharmacol Ther. 2008;83(2):251-7.
Choi, J. H., Lee, M. G., Cho, J. Y., Lee, J. E., Kim, K. H., & Park, K. (2008). Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. Clinical Pharmacology and Therapeutics, 83(2), 251-7.
Choi JH, et al. Influence of OATP1B1 Genotype On the Pharmacokinetics of Rosuvastatin in Koreans. Clin Pharmacol Ther. 2008;83(2):251-7. PubMed PMID: 17568401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans. AU - Choi,J H, AU - Lee,M G, AU - Cho,J-Y, AU - Lee,J-E, AU - Kim,K H, AU - Park,K, Y1 - 2007/06/13/ PY - 2007/6/15/pubmed PY - 2008/2/22/medline PY - 2007/6/15/entrez SP - 251 EP - 7 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 83 IS - 2 N2 - This study was carried out to determine whether polymorphisms of organic anion-transporting polypeptide 1B1 (OATP1B1) have an effect on rosuvastatin pharmacokinetics in Koreans. Among 200 subjects genotyped for OATP1B1 c.388A>G, and c.521T>C, 30 subjects were selected for the rosuvastatin pharmacokinetic study. The area under the concentration-time curve for 0 to infinity (AUC(0-infinity)) of rosuvastatin for group 1 (*1a/*1a, *1a/*1b, *1b/*1b), group 2 (*1a/*15, *1b/*15), and group 3 (*15/*15) were 111+/-49.3, 126+/-45.2, and 191+/-31.0 ng h/ml, respectively, with significant differences among the three groups (P=0.0429) and between *15/*15 and the other groups (P=0.0181). The maximum plasma concentration (Cmax) also showed a significant difference between *15/*15 and the other groups (P=0.0181). There were no significant differences in rosuvastatin-lactone pharmacokinetics among the three groups. The pharmacokinetic exposure of rosuvastatin was higher in the OATP1B1*15/*15 subjects than the others, suggesting a potential association between the OATP1B1 genetic polymorphisms and altered rosuvastatin pharmacokinetics in Korean populations. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/17568401/Influence_of_OATP1B1_genotype_on_the_pharmacokinetics_of_rosuvastatin_in_Koreans_ L2 - https://doi.org/10.1038/sj.clpt.6100267 DB - PRIME DP - Unbound Medicine ER -