Tags

Type your tag names separated by a space and hit enter

Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union.
Acta Trop. 2007 Jun; 102(3):176-81.AT

Abstract

Health policy makers in Comoros Union have considered a policy change recommending combination treatment to control malaria. We evaluated the efficacy of three antimalarial drug combinations, taken orally, to enable the authorities to make an evidence-based choice. The study was carried out in patients of 2-70 years old in Moroni, Moheli and Anjouan in 2003. We enrolled 168 patients with uncomplicated malaria from 1097 outpatients screened at the health centres. One hundred and fifty-eight patients, of whom half were under five years old, (mean age=11.1+/-13.9 years), were followed up for 14 days. According to PCR adjusted outcome, the therapeutic efficacy of artesunate+amodiaquine (AS+AQ) (n=54) and artesunate+sulfadoxine-pyrimethamine (AS+SP) (n=53) was 100%, whereas that of chloroquine+sulfadoxine-pyrimethamine (CQ+SP) was 98% (50/51). The key difference between these treatments was the higher parasite clearance rate on Day 2 obtained with artesunate-containing combinations (P<0.001). These results provide a baseline for monitoring changes in the susceptibility of Plasmodium falciparum to artesunate+amodiaquine and artesunate+sulfadoxine-pyrimethamine (ACTs) in the Comoros Union. Health policy changes involving the replacement of chloroquine in the Indian Ocean subregion are discussed.

Authors+Show Affiliations

Unité de recherche sur le paludisme, Institut Pasteur de Madagascar, BP 1274 Antananarivo (101), Madagascar.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17568549

Citation

Tall, Adama, et al. "Efficacy of Artesunate Plus Amodiaquine, Artesunate Plus Sulfadoxine-pyrimethamine, and Chloroquine Plus Sulfadoxine-pyrimethamine in Patients With Uncomplicated Plasmodium Falciparum in the Comoros Union." Acta Tropica, vol. 102, no. 3, 2007, pp. 176-81.
Tall A, Rabarijaona LP, Robert V, et al. Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union. Acta Trop. 2007;102(3):176-81.
Tall, A., Rabarijaona, L. P., Robert, V., Bedja, S. A., Ariey, F., & Randrianarivelojosia, M. (2007). Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union. Acta Tropica, 102(3), 176-81.
Tall A, et al. Efficacy of Artesunate Plus Amodiaquine, Artesunate Plus Sulfadoxine-pyrimethamine, and Chloroquine Plus Sulfadoxine-pyrimethamine in Patients With Uncomplicated Plasmodium Falciparum in the Comoros Union. Acta Trop. 2007;102(3):176-81. PubMed PMID: 17568549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of artesunate plus amodiaquine, artesunate plus sulfadoxine-pyrimethamine, and chloroquine plus sulfadoxine-pyrimethamine in patients with uncomplicated Plasmodium falciparum in the Comoros Union. AU - Tall,Adama, AU - Rabarijaona,Léon P, AU - Robert,Vincent, AU - Bedja,Said Ahmed, AU - Ariey,Frédéric, AU - Randrianarivelojosia,Milijaona, Y1 - 2007/05/03/ PY - 2007/03/25/received PY - 2007/03/25/accepted PY - 2007/6/15/pubmed PY - 2007/10/4/medline PY - 2007/6/15/entrez SP - 176 EP - 81 JF - Acta tropica JO - Acta Trop VL - 102 IS - 3 N2 - Health policy makers in Comoros Union have considered a policy change recommending combination treatment to control malaria. We evaluated the efficacy of three antimalarial drug combinations, taken orally, to enable the authorities to make an evidence-based choice. The study was carried out in patients of 2-70 years old in Moroni, Moheli and Anjouan in 2003. We enrolled 168 patients with uncomplicated malaria from 1097 outpatients screened at the health centres. One hundred and fifty-eight patients, of whom half were under five years old, (mean age=11.1+/-13.9 years), were followed up for 14 days. According to PCR adjusted outcome, the therapeutic efficacy of artesunate+amodiaquine (AS+AQ) (n=54) and artesunate+sulfadoxine-pyrimethamine (AS+SP) (n=53) was 100%, whereas that of chloroquine+sulfadoxine-pyrimethamine (CQ+SP) was 98% (50/51). The key difference between these treatments was the higher parasite clearance rate on Day 2 obtained with artesunate-containing combinations (P<0.001). These results provide a baseline for monitoring changes in the susceptibility of Plasmodium falciparum to artesunate+amodiaquine and artesunate+sulfadoxine-pyrimethamine (ACTs) in the Comoros Union. Health policy changes involving the replacement of chloroquine in the Indian Ocean subregion are discussed. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/17568549/Efficacy_of_artesunate_plus_amodiaquine_artesunate_plus_sulfadoxine_pyrimethamine_and_chloroquine_plus_sulfadoxine_pyrimethamine_in_patients_with_uncomplicated_Plasmodium_falciparum_in_the_Comoros_Union_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(07)00118-0 DB - PRIME DP - Unbound Medicine ER -