Tags

Type your tag names separated by a space and hit enter

Systemic antihypertensive medication and incident open-angle glaucoma.
Ophthalmology 2007; 114(12):2221-6O

Abstract

PURPOSE

To determine the association between systemic antihypertensive medication and incident open-angle glaucoma.

DESIGN

Prospective population-based cohort study.

PARTICIPANTS

The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical ophthalmologic examinations at baseline and follow-up were available.

METHODS

Use of antihypertensive medication was registered over an average follow-up period of 6.5 years. Associations between incident open-angle glaucoma and antihypertensive medication were assessed using multivariate logistic regression models adjusted for age, gender, duration of follow-up, intraocular pressure, intraocular pressure-lowering medication, and cardiovascular disease.

MAIN OUTCOME MEASURES

Odds ratios of associations between incident open-angle glaucoma and use of antihypertensive medication.

RESULTS

During follow-up, there were 87 incident cases of open-angle glaucoma. Participants using calcium channel antagonists had a 1.8-fold (95% confidence interval [CI], 1.04-3.2; P = 0.037) higher risk of developing incident open-angle glaucoma. beta-Blockers were associated with a nonsignificant risk reduction (odds ratio, 0.6; 95% CI, 0.3-1.02; P = 0.060). None of the other classes of antihypertensives was significantly associated with incident open-angle glaucoma.

CONCLUSIONS

These data suggest that use of calcium channel antagonists is associated with open-angle glaucoma, but this requires confirmation. These results do not support the use of calcium channel antagonists for the treatment of normal-tension glaucoma.

Authors+Show Affiliations

Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17568677

Citation

Müskens, Rogier P H M., et al. "Systemic Antihypertensive Medication and Incident Open-angle Glaucoma." Ophthalmology, vol. 114, no. 12, 2007, pp. 2221-6.
Müskens RP, de Voogd S, Wolfs RC, et al. Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology. 2007;114(12):2221-6.
Müskens, R. P., de Voogd, S., Wolfs, R. C., Witteman, J. C., Hofman, A., de Jong, P. T., ... Jansonius, N. M. (2007). Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology, 114(12), pp. 2221-6.
Müskens RP, et al. Systemic Antihypertensive Medication and Incident Open-angle Glaucoma. Ophthalmology. 2007;114(12):2221-6. PubMed PMID: 17568677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic antihypertensive medication and incident open-angle glaucoma. AU - Müskens,Rogier P H M, AU - de Voogd,Simone, AU - Wolfs,Roger C W, AU - Witteman,Jacqueline C M, AU - Hofman,Albert, AU - de Jong,Paulus T V M, AU - Stricker,Bruno H C, AU - Jansonius,Nomdo M, Y1 - 2007/06/12/ PY - 2006/09/15/received PY - 2007/03/19/revised PY - 2007/03/20/accepted PY - 2007/6/15/pubmed PY - 2007/12/19/medline PY - 2007/6/15/entrez SP - 2221 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 12 N2 - PURPOSE: To determine the association between systemic antihypertensive medication and incident open-angle glaucoma. DESIGN: Prospective population-based cohort study. PARTICIPANTS: The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical ophthalmologic examinations at baseline and follow-up were available. METHODS: Use of antihypertensive medication was registered over an average follow-up period of 6.5 years. Associations between incident open-angle glaucoma and antihypertensive medication were assessed using multivariate logistic regression models adjusted for age, gender, duration of follow-up, intraocular pressure, intraocular pressure-lowering medication, and cardiovascular disease. MAIN OUTCOME MEASURES: Odds ratios of associations between incident open-angle glaucoma and use of antihypertensive medication. RESULTS: During follow-up, there were 87 incident cases of open-angle glaucoma. Participants using calcium channel antagonists had a 1.8-fold (95% confidence interval [CI], 1.04-3.2; P = 0.037) higher risk of developing incident open-angle glaucoma. beta-Blockers were associated with a nonsignificant risk reduction (odds ratio, 0.6; 95% CI, 0.3-1.02; P = 0.060). None of the other classes of antihypertensives was significantly associated with incident open-angle glaucoma. CONCLUSIONS: These data suggest that use of calcium channel antagonists is associated with open-angle glaucoma, but this requires confirmation. These results do not support the use of calcium channel antagonists for the treatment of normal-tension glaucoma. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17568677/Systemic_antihypertensive_medication_and_incident_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00328-4 DB - PRIME DP - Unbound Medicine ER -