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Systemic antihypertensive medication and incident open-angle glaucoma.

Abstract

PURPOSE

To determine the association between systemic antihypertensive medication and incident open-angle glaucoma.

DESIGN

Prospective population-based cohort study.

PARTICIPANTS

The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical ophthalmologic examinations at baseline and follow-up were available.

METHODS

Use of antihypertensive medication was registered over an average follow-up period of 6.5 years. Associations between incident open-angle glaucoma and antihypertensive medication were assessed using multivariate logistic regression models adjusted for age, gender, duration of follow-up, intraocular pressure, intraocular pressure-lowering medication, and cardiovascular disease.

MAIN OUTCOME MEASURES

Odds ratios of associations between incident open-angle glaucoma and use of antihypertensive medication.

RESULTS

During follow-up, there were 87 incident cases of open-angle glaucoma. Participants using calcium channel antagonists had a 1.8-fold (95% confidence interval [CI], 1.04-3.2; P = 0.037) higher risk of developing incident open-angle glaucoma. beta-Blockers were associated with a nonsignificant risk reduction (odds ratio, 0.6; 95% CI, 0.3-1.02; P = 0.060). None of the other classes of antihypertensives was significantly associated with incident open-angle glaucoma.

CONCLUSIONS

These data suggest that use of calcium channel antagonists is associated with open-angle glaucoma, but this requires confirmation. These results do not support the use of calcium channel antagonists for the treatment of normal-tension glaucoma.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

    , , , , , ,

    Source

    Ophthalmology 114:12 2007 Dec pg 2221-6

    MeSH

    Adrenergic beta-Antagonists
    Aged
    Angiotensin-Converting Enzyme Inhibitors
    Antihypertensive Agents
    Calcium Channel Blockers
    Cardiovascular Diseases
    Diuretics
    Drug Prescriptions
    Female
    Follow-Up Studies
    Glaucoma, Open-Angle
    Humans
    Incidence
    Intraocular Pressure
    Male
    Multivariate Analysis
    Netherlands
    Odds Ratio
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17568677

    Citation

    Müskens, Rogier P H M., et al. "Systemic Antihypertensive Medication and Incident Open-angle Glaucoma." Ophthalmology, vol. 114, no. 12, 2007, pp. 2221-6.
    Müskens RP, de Voogd S, Wolfs RC, et al. Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology. 2007;114(12):2221-6.
    Müskens, R. P., de Voogd, S., Wolfs, R. C., Witteman, J. C., Hofman, A., de Jong, P. T., ... Jansonius, N. M. (2007). Systemic antihypertensive medication and incident open-angle glaucoma. Ophthalmology, 114(12), pp. 2221-6.
    Müskens RP, et al. Systemic Antihypertensive Medication and Incident Open-angle Glaucoma. Ophthalmology. 2007;114(12):2221-6. PubMed PMID: 17568677.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Systemic antihypertensive medication and incident open-angle glaucoma. AU - Müskens,Rogier P H M, AU - de Voogd,Simone, AU - Wolfs,Roger C W, AU - Witteman,Jacqueline C M, AU - Hofman,Albert, AU - de Jong,Paulus T V M, AU - Stricker,Bruno H C, AU - Jansonius,Nomdo M, Y1 - 2007/06/12/ PY - 2006/09/15/received PY - 2007/03/19/revised PY - 2007/03/20/accepted PY - 2007/6/15/pubmed PY - 2007/12/19/medline PY - 2007/6/15/entrez SP - 2221 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 12 N2 - PURPOSE: To determine the association between systemic antihypertensive medication and incident open-angle glaucoma. DESIGN: Prospective population-based cohort study. PARTICIPANTS: The study population consisted of a subset of 3842 participants of the Rotterdam Study for whom data from identical ophthalmologic examinations at baseline and follow-up were available. METHODS: Use of antihypertensive medication was registered over an average follow-up period of 6.5 years. Associations between incident open-angle glaucoma and antihypertensive medication were assessed using multivariate logistic regression models adjusted for age, gender, duration of follow-up, intraocular pressure, intraocular pressure-lowering medication, and cardiovascular disease. MAIN OUTCOME MEASURES: Odds ratios of associations between incident open-angle glaucoma and use of antihypertensive medication. RESULTS: During follow-up, there were 87 incident cases of open-angle glaucoma. Participants using calcium channel antagonists had a 1.8-fold (95% confidence interval [CI], 1.04-3.2; P = 0.037) higher risk of developing incident open-angle glaucoma. beta-Blockers were associated with a nonsignificant risk reduction (odds ratio, 0.6; 95% CI, 0.3-1.02; P = 0.060). None of the other classes of antihypertensives was significantly associated with incident open-angle glaucoma. CONCLUSIONS: These data suggest that use of calcium channel antagonists is associated with open-angle glaucoma, but this requires confirmation. These results do not support the use of calcium channel antagonists for the treatment of normal-tension glaucoma. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17568677/Systemic_antihypertensive_medication_and_incident_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00328-4 DB - PRIME DP - Unbound Medicine ER -