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Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats.

Abstract

Cadmium (Cd) induces extensive membrane damage that contributes to the cytotoxic effect of Cd. We studied the effect of diallyl tetrasulfide (DTS) from garlic on Cd-induced changes in lipid peroxidation and membrane-bound enzymes in liver, kidney, and testis of rats. Cadmium exposure (3 mg/kg body weight, s.c) for 3 weeks induced a significant elevation in the levels of lipid peroxidation markers (thiobarbituric acid substances and lipid hydroperoxides) with a significant decrease in the activities of membrane bound ATPases (Na+/K+ ATPase, Ca2+ ATPase, Mg2+ ATPase), the indicators of membrane function in liver, kidney and testis. The oral administration of DTS (40 mg/kg body weight) along with Cd significantly decreased the level of lipid peroxidation and significantly restored the activities of membrane bound ATPases. The results of our study suggest that DTS attenuates lipid peroxidation in tissues and promotes the stability of the membrane by protecting it from Cd-induced alterations.

Authors+Show Affiliations

,

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India.

Source

MeSH

Adenosine Triphosphatases
Allyl Compounds
Animals
Ca(2+) Mg(2+)-ATPase
Cadmium Chloride
Calcium-Transporting ATPases
Cell Membrane
Garlic
Kidney
Lipid Peroxidation
Lipid Peroxides
Liver
Male
Membrane Proteins
Rats
Rats, Wistar
Sodium-Potassium-Exchanging ATPase
Sulfides
Testis
Thiobarbiturates

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17569245

Citation

Murugavel, P, and L Pari. "Diallyl Tetrasulfide Modulates the Cadmium-induced Impairment of Membrane Bound Enzymes in Rats." Journal of Basic and Clinical Physiology and Pharmacology, vol. 18, no. 1, 2007, pp. 37-48.
Murugavel P, Pari L. Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. J Basic Clin Physiol Pharmacol. 2007;18(1):37-48.
Murugavel, P., & Pari, L. (2007). Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. Journal of Basic and Clinical Physiology and Pharmacology, 18(1), pp. 37-48.
Murugavel P, Pari L. Diallyl Tetrasulfide Modulates the Cadmium-induced Impairment of Membrane Bound Enzymes in Rats. J Basic Clin Physiol Pharmacol. 2007;18(1):37-48. PubMed PMID: 17569245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diallyl tetrasulfide modulates the cadmium-induced impairment of membrane bound enzymes in rats. AU - Murugavel,P, AU - Pari,L, PY - 2007/6/16/pubmed PY - 2007/7/7/medline PY - 2007/6/16/entrez SP - 37 EP - 48 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 18 IS - 1 N2 - Cadmium (Cd) induces extensive membrane damage that contributes to the cytotoxic effect of Cd. We studied the effect of diallyl tetrasulfide (DTS) from garlic on Cd-induced changes in lipid peroxidation and membrane-bound enzymes in liver, kidney, and testis of rats. Cadmium exposure (3 mg/kg body weight, s.c) for 3 weeks induced a significant elevation in the levels of lipid peroxidation markers (thiobarbituric acid substances and lipid hydroperoxides) with a significant decrease in the activities of membrane bound ATPases (Na+/K+ ATPase, Ca2+ ATPase, Mg2+ ATPase), the indicators of membrane function in liver, kidney and testis. The oral administration of DTS (40 mg/kg body weight) along with Cd significantly decreased the level of lipid peroxidation and significantly restored the activities of membrane bound ATPases. The results of our study suggest that DTS attenuates lipid peroxidation in tissues and promotes the stability of the membrane by protecting it from Cd-induced alterations. SN - 0792-6855 UR - https://www.unboundmedicine.com/medline/citation/17569245/Diallyl_tetrasulfide_modulates_the_cadmium_induced_impairment_of_membrane_bound_enzymes_in_rats_ DB - PRIME DP - Unbound Medicine ER -