Tags

Type your tag names separated by a space and hit enter

[Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun; 26 Suppl:43-6.ZZ

Abstract

OBJECTIVE

To observe the changing contents of leukotriene B4 (LTB4), leukotriene C4 (LTC4), and leukotriene D4 (LTD4) of lung tissue in asthmatic rats, and explore the effect of Shuanglong Capsule (SLC) on it.

METHODS

SD rats were randomly divided into the nomal group, asthmatic model group, Dexamethasone group and the high, middle and low dose SLC groups. All rats except those in the normal group were sensitized by ovalbumin and challenged with the antigen, and the contents of LTB4, LTC4 and LTD4 in lung tissue of all the groups were measured by reverse phase-high performance liquid chromatography (RP-HPLC) and compared.

RESULTS

The levels of LTB4, LTC4, and LTD4 of asthmatic rats were significantly higher than those of rats in the normal group. Dexamethasone and SLC at the dose of 8. 27 g/kg or 4. 13 g/kg could significantly inhibit the production of leukotrienes of lung tissue in asthmatic rats (P <0.05).

CONCLUSION

SLC can significantly inhibit the formation of inflammatory medium LTs of lung tissue in asthmatic rats, it may be one of the key mechanisms of SLC in anti-asthma and anti-inflammatory action.

Authors+Show Affiliations

Beijing University of Chinese Medicine, Beijing. zylab208@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17569344

Citation

Yang, Zhi-hui, et al. "[Effect of Shuanglong Capsule On Content of Leukotrienes Compound of Lung Tissues in Asthmatic Rats]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 26 Suppl, 2006, pp. 43-6.
Yang ZH, Zhang JJ, Wang LY. [Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26 Suppl:43-6.
Yang, Z. H., Zhang, J. J., & Wang, L. Y. (2006). [Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 26 Suppl, 43-6.
Yang ZH, Zhang JJ, Wang LY. [Effect of Shuanglong Capsule On Content of Leukotrienes Compound of Lung Tissues in Asthmatic Rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26 Suppl:43-6. PubMed PMID: 17569344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats]. AU - Yang,Zhi-hui, AU - Zhang,Jian-jun, AU - Wang,Lin-yuan, PY - 2007/6/16/pubmed PY - 2010/6/25/medline PY - 2007/6/16/entrez SP - 43 EP - 6 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 26 Suppl N2 - OBJECTIVE: To observe the changing contents of leukotriene B4 (LTB4), leukotriene C4 (LTC4), and leukotriene D4 (LTD4) of lung tissue in asthmatic rats, and explore the effect of Shuanglong Capsule (SLC) on it. METHODS: SD rats were randomly divided into the nomal group, asthmatic model group, Dexamethasone group and the high, middle and low dose SLC groups. All rats except those in the normal group were sensitized by ovalbumin and challenged with the antigen, and the contents of LTB4, LTC4 and LTD4 in lung tissue of all the groups were measured by reverse phase-high performance liquid chromatography (RP-HPLC) and compared. RESULTS: The levels of LTB4, LTC4, and LTD4 of asthmatic rats were significantly higher than those of rats in the normal group. Dexamethasone and SLC at the dose of 8. 27 g/kg or 4. 13 g/kg could significantly inhibit the production of leukotrienes of lung tissue in asthmatic rats (P <0.05). CONCLUSION: SLC can significantly inhibit the formation of inflammatory medium LTs of lung tissue in asthmatic rats, it may be one of the key mechanisms of SLC in anti-asthma and anti-inflammatory action. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/17569344/[Effect_of_shuanglong_capsule_on_content_of_leukotrienes_compound_of_lung_tissues_in_asthmatic_rats]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -