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Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy.
J Urol. 2007 Aug; 178(2):613-6.JU

Abstract

PURPOSE

We prospectively investigated whether postoperative statin use would contribute to earlier recovery of erectile function in men who underwent bilateral nerve sparing radical retropubic prostatectomy for clinically localized prostate cancer.

MATERIALS AND METHODS

A total of 50 potent men without hypercholesterolemia undergoing bilateral nerve sparing radical retropubic prostatectomy for clinically localized prostate cancer were prospectively randomized into 2 equal groups. Group 1 patients were instructed to ingest only 50 mg sildenafil per day if needed following hospital discharge after radical retropubic prostatectomy. Group 2 patients were prescribed atorvastatin at a dose of 10 mg daily from postoperative days 1 to 90 and they were also instructed to ingest sildenafil, as in group 1. Patient status regarding potency and adverse events were assessed 6 months after surgery.

RESULTS

The 2 groups demonstrated no significant differences regarding various baseline factors, including International Index of Erectile Function-5 scores. Group 2 had a significantly higher postoperative International Index of Erectile Function-5 score than group 1 at 6 months postoperatively (p = 0.003). Meanwhile, as judged by a preset definition, the incidence of potent patients 6 months after prostatectomy was 26.1% in group 1 and 55% in group 2 (p = 0.068). Also, 17.4% and 40% of the men reported achieving intercourse by vaginal penetration without a phosphodiesterase 5 inhibitor in groups 1 and 2, respectively (p = 0.172). No serious adverse events associated with medication were reported.

CONCLUSIONS

Postoperative treatment with atorvastatin in men who report normal erectile function preoperatively may contribute to earlier recovery of erectile function after nerve sparing radical retropubic prostatectomy.

Authors+Show Affiliations

Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17570410

Citation

Hong, Sung Kyu, et al. "Effect of Statin Therapy On Early Return of Potency After Nerve Sparing Radical Retropubic Prostatectomy." The Journal of Urology, vol. 178, no. 2, 2007, pp. 613-6.
Hong SK, Han BK, Jeong SJ, et al. Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy. J Urol. 2007;178(2):613-6.
Hong, S. K., Han, B. K., Jeong, S. J., Byun, S. S., & Lee, S. E. (2007). Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy. The Journal of Urology, 178(2), 613-6.
Hong SK, et al. Effect of Statin Therapy On Early Return of Potency After Nerve Sparing Radical Retropubic Prostatectomy. J Urol. 2007;178(2):613-6. PubMed PMID: 17570410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy. AU - Hong,Sung Kyu, AU - Han,Byung Kyu, AU - Jeong,Seong Jin, AU - Byun,Seok-Soo, AU - Lee,Sang Eun, Y1 - 2007/06/13/ PY - 2007/01/09/received PY - 2007/6/16/pubmed PY - 2007/8/23/medline PY - 2007/6/16/entrez SP - 613 EP - 6 JF - The Journal of urology JO - J Urol VL - 178 IS - 2 N2 - PURPOSE: We prospectively investigated whether postoperative statin use would contribute to earlier recovery of erectile function in men who underwent bilateral nerve sparing radical retropubic prostatectomy for clinically localized prostate cancer. MATERIALS AND METHODS: A total of 50 potent men without hypercholesterolemia undergoing bilateral nerve sparing radical retropubic prostatectomy for clinically localized prostate cancer were prospectively randomized into 2 equal groups. Group 1 patients were instructed to ingest only 50 mg sildenafil per day if needed following hospital discharge after radical retropubic prostatectomy. Group 2 patients were prescribed atorvastatin at a dose of 10 mg daily from postoperative days 1 to 90 and they were also instructed to ingest sildenafil, as in group 1. Patient status regarding potency and adverse events were assessed 6 months after surgery. RESULTS: The 2 groups demonstrated no significant differences regarding various baseline factors, including International Index of Erectile Function-5 scores. Group 2 had a significantly higher postoperative International Index of Erectile Function-5 score than group 1 at 6 months postoperatively (p = 0.003). Meanwhile, as judged by a preset definition, the incidence of potent patients 6 months after prostatectomy was 26.1% in group 1 and 55% in group 2 (p = 0.068). Also, 17.4% and 40% of the men reported achieving intercourse by vaginal penetration without a phosphodiesterase 5 inhibitor in groups 1 and 2, respectively (p = 0.172). No serious adverse events associated with medication were reported. CONCLUSIONS: Postoperative treatment with atorvastatin in men who report normal erectile function preoperatively may contribute to earlier recovery of erectile function after nerve sparing radical retropubic prostatectomy. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17570410/Effect_of_statin_therapy_on_early_return_of_potency_after_nerve_sparing_radical_retropubic_prostatectomy_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.03.132?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -