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Age related pathogenesis of nocturia in patients with overactive bladder.
J Urol. 2007 Aug; 178(2):548-51; discussion 551.JU

Abstract

PURPOSE

Nocturia is caused by increased nocturnal urine output (nocturnal polyuria) and/or diminished nocturnal bladder capacity. We retrospectively evaluated the causes of nocturia in patients with overactive bladder and nocturia.

MATERIALS AND METHODS

A total of 850 patients (18 years or older) with symptoms of overactive bladder (8 or more micturitions per 24 hours and urgency or urgency urinary incontinence) and nocturia (mean of 2.5 or more episodes per night) were enrolled in a 12-week study of tolterodine ER (4 mg QD) vs placebo. Of this total 845 patients (417 men and 428 women) completed 7-day bladder diaries. Patients were stratified post hoc by sex and age groups (less than 50, 50 to 70, more than 70 years). Indices of nocturnal urine production (nocturia index, nocturnal polyuria index and nocturnal bladder capacity index) were compared using ANOVA (alpha level 0.05). Higher nocturia index and nocturnal polyuria index values suggest that nocturia occurs because of nocturnal urine overproduction. Higher nocturnal bladder capacity index values suggest that nocturia occurs because of decreased nocturnal bladder capacity.

RESULTS

There were no statistically significant gender or age related differences in baseline nocturnal micturitions. Nocturia index increased significantly with age (p <0.0001), and values were significantly higher among men than women for all age groups (p = 0.0064). Nocturnal polyuria index increased significantly with age (p <0.0001) and there were no gender differences. For nocturnal bladder capacity index there was a significant decrease with advancing age among men (1.75 greater than 1.16 greater than 0.90) and women (1.53 greater than 1.42 greater than 1.08, P(interaction) = 0.0148).

CONCLUSIONS

In younger patients with overactive bladder, decreased nocturnal bladder capacity has a greater role in the pathogenesis of nocturia symptoms, whereas in older patients increased nocturnal urine output has a greater role.

Authors+Show Affiliations

Weill Cornell Medical Center, New York, New York 10021, USA. urojock@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17570424

Citation

Weiss, Jeffrey P., et al. "Age Related Pathogenesis of Nocturia in Patients With Overactive Bladder." The Journal of Urology, vol. 178, no. 2, 2007, pp. 548-51; discussion 551.
Weiss JP, Blaivas JG, Jones M, et al. Age related pathogenesis of nocturia in patients with overactive bladder. J Urol. 2007;178(2):548-51; discussion 551.
Weiss, J. P., Blaivas, J. G., Jones, M., Wang, J. T., & Guan, Z. (2007). Age related pathogenesis of nocturia in patients with overactive bladder. The Journal of Urology, 178(2), 548-51; discussion 551.
Weiss JP, et al. Age Related Pathogenesis of Nocturia in Patients With Overactive Bladder. J Urol. 2007;178(2):548-51; discussion 551. PubMed PMID: 17570424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age related pathogenesis of nocturia in patients with overactive bladder. AU - Weiss,Jeffrey P, AU - Blaivas,Jerry G, AU - Jones,Mark, AU - Wang,Joseph T, AU - Guan,Zhonghong, AU - ,, Y1 - 2007/06/14/ PY - 2006/12/08/received PY - 2007/6/16/pubmed PY - 2007/8/23/medline PY - 2007/6/16/entrez SP - 548-51; discussion 551 JF - The Journal of urology JO - J. Urol. VL - 178 IS - 2 N2 - PURPOSE: Nocturia is caused by increased nocturnal urine output (nocturnal polyuria) and/or diminished nocturnal bladder capacity. We retrospectively evaluated the causes of nocturia in patients with overactive bladder and nocturia. MATERIALS AND METHODS: A total of 850 patients (18 years or older) with symptoms of overactive bladder (8 or more micturitions per 24 hours and urgency or urgency urinary incontinence) and nocturia (mean of 2.5 or more episodes per night) were enrolled in a 12-week study of tolterodine ER (4 mg QD) vs placebo. Of this total 845 patients (417 men and 428 women) completed 7-day bladder diaries. Patients were stratified post hoc by sex and age groups (less than 50, 50 to 70, more than 70 years). Indices of nocturnal urine production (nocturia index, nocturnal polyuria index and nocturnal bladder capacity index) were compared using ANOVA (alpha level 0.05). Higher nocturia index and nocturnal polyuria index values suggest that nocturia occurs because of nocturnal urine overproduction. Higher nocturnal bladder capacity index values suggest that nocturia occurs because of decreased nocturnal bladder capacity. RESULTS: There were no statistically significant gender or age related differences in baseline nocturnal micturitions. Nocturia index increased significantly with age (p <0.0001), and values were significantly higher among men than women for all age groups (p = 0.0064). Nocturnal polyuria index increased significantly with age (p <0.0001) and there were no gender differences. For nocturnal bladder capacity index there was a significant decrease with advancing age among men (1.75 greater than 1.16 greater than 0.90) and women (1.53 greater than 1.42 greater than 1.08, P(interaction) = 0.0148). CONCLUSIONS: In younger patients with overactive bladder, decreased nocturnal bladder capacity has a greater role in the pathogenesis of nocturia symptoms, whereas in older patients increased nocturnal urine output has a greater role. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17570424/Age_related_pathogenesis_of_nocturia_in_patients_with_overactive_bladder_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2007.03.117?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -