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Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta.
Phytochemistry. 2007 Jul; 68(13):1767-74.P

Abstract

Bioactivity-guided separation of an antifungal extract from the liverwort Asterella angusta afforded four bis(bibenzyl)s, asterelin A (1), asterelin B (2), 11-O-demethyl marchantin I (3), and dihydroptychantol A (4), together with six known ones. Their structures were established by extensive spectroscopic analysis (1D and 2D-NMR, MS), and that of 2 was confirmed by X-ray crystallographic diffraction analysis. Compounds 1 and 2 are the first examples of dibenzofuran bis(bibenzyl)s. The antifungal activity of the isolated bis(bibenzyl)s against the common clinical pathogenic fungus Candida albicans was evaluated using both the thin-layer chromatography bioautographic assay and the broth microdilution method. They showed moderate antifungal activities with minimal inhibitory concentration (MIC) values ranging from 16 microg/ml to 512 microg/ml.

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Authors+Show Affiliations

Qu J
School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Xie C
No affiliation info available
Guo H
No affiliation info available
Yu W
No affiliation info available
Lou H
No affiliation info available

MeSH

Antifungal AgentsBenzofuransBibenzylsCandida albicansCrystallography, X-RayHepatophytaMass SpectrometryMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, Biomolecular

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17570447

Citation

Qu, Jianbo, et al. "Antifungal Dibenzofuran Bis(bibenzyl)s From the Liverwort Asterella Angusta." Phytochemistry, vol. 68, no. 13, 2007, pp. 1767-74.
Qu J, Xie C, Guo H, et al. Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta. Phytochemistry. 2007;68(13):1767-74.
Qu, J., Xie, C., Guo, H., Yu, W., & Lou, H. (2007). Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta. Phytochemistry, 68(13), 1767-74.
Qu J, et al. Antifungal Dibenzofuran Bis(bibenzyl)s From the Liverwort Asterella Angusta. Phytochemistry. 2007;68(13):1767-74. PubMed PMID: 17570447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta. AU - Qu,Jianbo, AU - Xie,Chunfeng, AU - Guo,Huaifang, AU - Yu,Wentao, AU - Lou,Hongxiang, Y1 - 2007/06/13/ PY - 2006/10/02/received PY - 2007/02/13/revised PY - 2007/04/27/accepted PY - 2007/6/16/pubmed PY - 2007/10/30/medline PY - 2007/6/16/entrez SP - 1767 EP - 74 JF - Phytochemistry JO - Phytochemistry VL - 68 IS - 13 N2 - Bioactivity-guided separation of an antifungal extract from the liverwort Asterella angusta afforded four bis(bibenzyl)s, asterelin A (1), asterelin B (2), 11-O-demethyl marchantin I (3), and dihydroptychantol A (4), together with six known ones. Their structures were established by extensive spectroscopic analysis (1D and 2D-NMR, MS), and that of 2 was confirmed by X-ray crystallographic diffraction analysis. Compounds 1 and 2 are the first examples of dibenzofuran bis(bibenzyl)s. The antifungal activity of the isolated bis(bibenzyl)s against the common clinical pathogenic fungus Candida albicans was evaluated using both the thin-layer chromatography bioautographic assay and the broth microdilution method. They showed moderate antifungal activities with minimal inhibitory concentration (MIC) values ranging from 16 microg/ml to 512 microg/ml. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/17570447/Antifungal_dibenzofuran_bis_bibenzyl_s_from_the_liverwort_Asterella_angusta_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(07)00296-8 DB - PRIME DP - Unbound Medicine ER -