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The spliceosome: a ribozyme at heart?
Biol Chem. 2007 Jul; 388(7):693-7.BC

Abstract

The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200 different proteins and five small nuclear RNAs (snRNAs). Extensive mechanistic and structural similarities to self-splicing group II introns, large ribozymes found in prokaryotes and lower eukaryotes that catalyze an identical reaction, strongly suggest that the spliceosomal RNAs are in fact the catalytic components of the spliceosome. Of the five spliceosomal RNAs, U2 and U6 are the only ones that are absolutely required for both steps of splicing. These two snRNAs form an elaborate base-paired complex that might in fact constitute the active site of the spliceosome.

Authors+Show Affiliations

Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA. saba.valadkhan@case.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17570821

Citation

Valadkhan, Saba. "The Spliceosome: a Ribozyme at Heart?" Biological Chemistry, vol. 388, no. 7, 2007, pp. 693-7.
Valadkhan S. The spliceosome: a ribozyme at heart? Biol Chem. 2007;388(7):693-7.
Valadkhan, S. (2007). The spliceosome: a ribozyme at heart? Biological Chemistry, 388(7), 693-7.
Valadkhan S. The Spliceosome: a Ribozyme at Heart. Biol Chem. 2007;388(7):693-7. PubMed PMID: 17570821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The spliceosome: a ribozyme at heart? A1 - Valadkhan,Saba, PY - 2007/6/16/pubmed PY - 2007/8/21/medline PY - 2007/6/16/entrez SP - 693 EP - 7 JF - Biological chemistry JO - Biol Chem VL - 388 IS - 7 N2 - The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200 different proteins and five small nuclear RNAs (snRNAs). Extensive mechanistic and structural similarities to self-splicing group II introns, large ribozymes found in prokaryotes and lower eukaryotes that catalyze an identical reaction, strongly suggest that the spliceosomal RNAs are in fact the catalytic components of the spliceosome. Of the five spliceosomal RNAs, U2 and U6 are the only ones that are absolutely required for both steps of splicing. These two snRNAs form an elaborate base-paired complex that might in fact constitute the active site of the spliceosome. SN - 1431-6730 UR - https://www.unboundmedicine.com/medline/citation/17570821/The_spliceosome:_a_ribozyme_at_heart L2 - https://www.degruyter.com/document/doi/10.1515/BC.2007.080 DB - PRIME DP - Unbound Medicine ER -