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Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma.
Nutr Cancer. 2007; 57(2):146-50.NC

Abstract

Dietary deficiency of folate and other micronutrients involved in the one-carbon metabolism (i.e., vitamins B2, B6, B12, and methionine) have been related to several diseases, including cancers, but results on non-Hodgkin lymphoma (NHL) are controversial. A hospital-based case-control study was conducted in Italy, in 1999-2002. Cases were 190 incident, histologically confirmed NHL aged 18-84 years. Controls were 484 subjects admitted to hospitals for acute, non-neoplastic diseases supposed to be unrelated to alcohol consumption or to diet modification. Dietary habits, including alcohol drinking, were assessed by a validated food-frequency questionnaire. Nutrient intakes were computed using the Italian food composition database. Odds ratios (ORs) and corresponding 95% confidence intervals for tertiles of nutrients' intake were computed using the energy-adjusted residual models. No significant association emerged between NHL risk and intakes of folate (OR=0.9), vitamin B2 (OR=0.9), vitamin B6 (OR=0.8), and methionine (OR=0.7). However, a significant inverse association was observed for all the nutrients examined among abstainers and former drinkers, whereas no relations between one-carbon nutrients and NHL risk emerged among current alcohol drinkers. Our findings support the possibility of an antagonist effect of alcohol on the one-carbon metabolism in NHL etiology. However, the lack of an overall effect for one-carbon nutrients and the small sample size suggested caution in interpreting our results.

Authors+Show Affiliations

Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Italy. polesel@cro.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17571947

Citation

Polesel, Jerry, et al. "Dietary Folate, Alcohol Consumption, and Risk of non-Hodgkin Lymphoma." Nutrition and Cancer, vol. 57, no. 2, 2007, pp. 146-50.
Polesel J, Dal Maso L, La Vecchia C, et al. Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma. Nutr Cancer. 2007;57(2):146-50.
Polesel, J., Dal Maso, L., La Vecchia, C., Montella, M., Spina, M., Crispo, A., Talamini, R., & Franceschi, S. (2007). Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma. Nutrition and Cancer, 57(2), 146-50.
Polesel J, et al. Dietary Folate, Alcohol Consumption, and Risk of non-Hodgkin Lymphoma. Nutr Cancer. 2007;57(2):146-50. PubMed PMID: 17571947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma. AU - Polesel,Jerry, AU - Dal Maso,Luigino, AU - La Vecchia,Carlo, AU - Montella,Maurizio, AU - Spina,Michele, AU - Crispo,Anna, AU - Talamini,Renato, AU - Franceschi,Silvia, PY - 2007/6/19/pubmed PY - 2007/9/12/medline PY - 2007/6/19/entrez SP - 146 EP - 50 JF - Nutrition and cancer JO - Nutr Cancer VL - 57 IS - 2 N2 - Dietary deficiency of folate and other micronutrients involved in the one-carbon metabolism (i.e., vitamins B2, B6, B12, and methionine) have been related to several diseases, including cancers, but results on non-Hodgkin lymphoma (NHL) are controversial. A hospital-based case-control study was conducted in Italy, in 1999-2002. Cases were 190 incident, histologically confirmed NHL aged 18-84 years. Controls were 484 subjects admitted to hospitals for acute, non-neoplastic diseases supposed to be unrelated to alcohol consumption or to diet modification. Dietary habits, including alcohol drinking, were assessed by a validated food-frequency questionnaire. Nutrient intakes were computed using the Italian food composition database. Odds ratios (ORs) and corresponding 95% confidence intervals for tertiles of nutrients' intake were computed using the energy-adjusted residual models. No significant association emerged between NHL risk and intakes of folate (OR=0.9), vitamin B2 (OR=0.9), vitamin B6 (OR=0.8), and methionine (OR=0.7). However, a significant inverse association was observed for all the nutrients examined among abstainers and former drinkers, whereas no relations between one-carbon nutrients and NHL risk emerged among current alcohol drinkers. Our findings support the possibility of an antagonist effect of alcohol on the one-carbon metabolism in NHL etiology. However, the lack of an overall effect for one-carbon nutrients and the small sample size suggested caution in interpreting our results. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17571947/Dietary_folate_alcohol_consumption_and_risk_of_non_Hodgkin_lymphoma_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701274202 DB - PRIME DP - Unbound Medicine ER -