Tags

Type your tag names separated by a space and hit enter

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
J Am Coll Cardiol. 2007 Jun 19; 49(24):2341-9.JACC

Abstract

OBJECTIVES

This study investigated whether reduced levels of circulating endothelial progenitors cells (EPCs) in chronic heart failure (CHF) are secondary to an exhaustion of hematopoietic stem cells (HSCs) in the bone marrow or to reduced mobilization.

BACKGROUND

Circulating EPCs presumably originate from bone marrow-derived HSC. Persistent mobilization of EPCs was shown to be associated with favorable left ventricular infarct remodeling processes.

METHODS

We assessed the number and functional capacity of EPCs in 17 healthy controls, 25 patients with ischemic cardiomyopathy (ICM), and 20 patients with dilated cardiomyopathy (DCM). To document an impairment of HSC function in the bone marrow, the colony-forming unit capacity of bone marrow-derived mononuclear cells and the number of CD34+ HSCs were examined in 6 healthy volunteers, 94 ICM patients, and 25 DCM patients.

RESULTS

The number of EPCs was reduced in CHF, irrespective of its etiology. In contrast, the migratory capacity was selectively impaired in EPCs of ICM patients (4.8 +/- 4.0 migrated cells; DCM 9.7 +/- 5.8; p = 0.02). On multivariate analysis, ICM, advanced New York Heart Association functional class, and CHF were independent predictors of functional EPC impairment. The number of bone marrow-derived CD34+ cells did not differ between the CHF populations. However, colony-forming units (CFUs) were selectively reduced in ICM patients (54.4 +/- 24.6; DCM 68.1 +/- 26.9; p < 0.02). Ischemic cardiomyopathy was the only independent predictor of impaired CFU capacity. Impaired CFU capacity was associated with reduced matrix metalloproteinase-9 activity in the bone marrow plasma.

CONCLUSIONS

Ischemic cardiomyopathy is associated with selective impairment of progenitor cell function in the bone marrow and in the peripheral blood, which may contribute to an unfavorable left ventricular (LV) remodeling process.

Authors+Show Affiliations

Department of Cardiology, Johann Wolfgang Goethe-University Frankfurt, Frankfurt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17572250

Citation

Kissel, Christine K., et al. "Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure." Journal of the American College of Cardiology, vol. 49, no. 24, 2007, pp. 2341-9.
Kissel CK, Lehmann R, Assmus B, et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol. 2007;49(24):2341-9.
Kissel, C. K., Lehmann, R., Assmus, B., Aicher, A., Honold, J., Fischer-Rasokat, U., Heeschen, C., Spyridopoulos, I., Dimmeler, S., & Zeiher, A. M. (2007). Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. Journal of the American College of Cardiology, 49(24), 2341-9.
Kissel CK, et al. Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure. J Am Coll Cardiol. 2007 Jun 19;49(24):2341-9. PubMed PMID: 17572250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. AU - Kissel,Christine K, AU - Lehmann,Ralf, AU - Assmus,Birgit, AU - Aicher,Alexandra, AU - Honold,Jörg, AU - Fischer-Rasokat,Ulrich, AU - Heeschen,Christopher, AU - Spyridopoulos,Ioakim, AU - Dimmeler,Stefanie, AU - Zeiher,Andreas M, Y1 - 2007/06/04/ PY - 2006/02/14/received PY - 2007/01/11/revised PY - 2007/01/22/accepted PY - 2007/6/19/pubmed PY - 2007/7/12/medline PY - 2007/6/19/entrez SP - 2341 EP - 9 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 49 IS - 24 N2 - OBJECTIVES: This study investigated whether reduced levels of circulating endothelial progenitors cells (EPCs) in chronic heart failure (CHF) are secondary to an exhaustion of hematopoietic stem cells (HSCs) in the bone marrow or to reduced mobilization. BACKGROUND: Circulating EPCs presumably originate from bone marrow-derived HSC. Persistent mobilization of EPCs was shown to be associated with favorable left ventricular infarct remodeling processes. METHODS: We assessed the number and functional capacity of EPCs in 17 healthy controls, 25 patients with ischemic cardiomyopathy (ICM), and 20 patients with dilated cardiomyopathy (DCM). To document an impairment of HSC function in the bone marrow, the colony-forming unit capacity of bone marrow-derived mononuclear cells and the number of CD34+ HSCs were examined in 6 healthy volunteers, 94 ICM patients, and 25 DCM patients. RESULTS: The number of EPCs was reduced in CHF, irrespective of its etiology. In contrast, the migratory capacity was selectively impaired in EPCs of ICM patients (4.8 +/- 4.0 migrated cells; DCM 9.7 +/- 5.8; p = 0.02). On multivariate analysis, ICM, advanced New York Heart Association functional class, and CHF were independent predictors of functional EPC impairment. The number of bone marrow-derived CD34+ cells did not differ between the CHF populations. However, colony-forming units (CFUs) were selectively reduced in ICM patients (54.4 +/- 24.6; DCM 68.1 +/- 26.9; p < 0.02). Ischemic cardiomyopathy was the only independent predictor of impaired CFU capacity. Impaired CFU capacity was associated with reduced matrix metalloproteinase-9 activity in the bone marrow plasma. CONCLUSIONS: Ischemic cardiomyopathy is associated with selective impairment of progenitor cell function in the bone marrow and in the peripheral blood, which may contribute to an unfavorable left ventricular (LV) remodeling process. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/17572250/Selective_functional_exhaustion_of_hematopoietic_progenitor_cells_in_the_bone_marrow_of_patients_with_postinfarction_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(07)01139-4 DB - PRIME DP - Unbound Medicine ER -