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The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.
Neuropharmacology 2007; 53(1):169-77N

Abstract

Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a real therapeutic challenge. At present there are few effective drugs. Here we have evaluated the effects of the synthetic cannabinoid WIN 55,212-2 on mechanical allodynia and thermal hyperalgesia in a rat model of trigeminal neuropathic pain produced by a chronic constriction injury (CCI) of the infraorbital branch of the trigeminal nerve (ION). Relative to sham operation controls, rats with the CCI-ION consistently displayed hyperresponsiveness to von Frey filament and heat stimulation of the vibrissal pad. Both mechanical allodynia and thermal hyperalgesia are seen both ipsilateral and contralateral to the side of nerve injury, but is significantly more severe ipsilaterally. Administration of WIN 55,212-2 (0.3-5 mg/kg i.p.) dose-dependently increased the mechanical and heat withdrawal thresholds. WIN 55,212-2 (0.3-3 mg/kg i.p.) produced no significant motor deficits in animals using the rotarod test. The effect of WIN 55,212-2 was mimicked by cannabinoid CB1 receptor agonist HU 210 and was antagonized by CB1 receptor antagonist AM 251, but not by CB2 receptor antagonist AM 630 or vanilloid receptor 1 antagonist capsazepine, suggesting the involvement of CB1 receptors. CCI-ION also induced a time-dependent upregulation of CB1 receptors primarily within the ipsilateral superficial laminae of the trigeminal caudal nucleus revealed by both Western blot and immunohistochemistry. Taken together, these results suggest that cannabinoids may be a useful therapeutic approach for the clinical management of trigeminal neuropathic pain disorders.

Authors+Show Affiliations

Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17572451

Citation

Liang, Ying-Ching, et al. "The Synthetic Cannabinoids Attenuate Allodynia and Hyperalgesia in a Rat Model of Trigeminal Neuropathic Pain." Neuropharmacology, vol. 53, no. 1, 2007, pp. 169-77.
Liang YC, Huang CC, Hsu KS. The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. Neuropharmacology. 2007;53(1):169-77.
Liang, Y. C., Huang, C. C., & Hsu, K. S. (2007). The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. Neuropharmacology, 53(1), pp. 169-77.
Liang YC, Huang CC, Hsu KS. The Synthetic Cannabinoids Attenuate Allodynia and Hyperalgesia in a Rat Model of Trigeminal Neuropathic Pain. Neuropharmacology. 2007;53(1):169-77. PubMed PMID: 17572451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. AU - Liang,Ying-Ching, AU - Huang,Chiung-Chun, AU - Hsu,Kuei-Sen, Y1 - 2007/05/13/ PY - 2006/12/20/received PY - 2007/04/26/revised PY - 2007/04/27/accepted PY - 2007/6/19/pubmed PY - 2007/11/10/medline PY - 2007/6/19/entrez SP - 169 EP - 77 JF - Neuropharmacology JO - Neuropharmacology VL - 53 IS - 1 N2 - Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a real therapeutic challenge. At present there are few effective drugs. Here we have evaluated the effects of the synthetic cannabinoid WIN 55,212-2 on mechanical allodynia and thermal hyperalgesia in a rat model of trigeminal neuropathic pain produced by a chronic constriction injury (CCI) of the infraorbital branch of the trigeminal nerve (ION). Relative to sham operation controls, rats with the CCI-ION consistently displayed hyperresponsiveness to von Frey filament and heat stimulation of the vibrissal pad. Both mechanical allodynia and thermal hyperalgesia are seen both ipsilateral and contralateral to the side of nerve injury, but is significantly more severe ipsilaterally. Administration of WIN 55,212-2 (0.3-5 mg/kg i.p.) dose-dependently increased the mechanical and heat withdrawal thresholds. WIN 55,212-2 (0.3-3 mg/kg i.p.) produced no significant motor deficits in animals using the rotarod test. The effect of WIN 55,212-2 was mimicked by cannabinoid CB1 receptor agonist HU 210 and was antagonized by CB1 receptor antagonist AM 251, but not by CB2 receptor antagonist AM 630 or vanilloid receptor 1 antagonist capsazepine, suggesting the involvement of CB1 receptors. CCI-ION also induced a time-dependent upregulation of CB1 receptors primarily within the ipsilateral superficial laminae of the trigeminal caudal nucleus revealed by both Western blot and immunohistochemistry. Taken together, these results suggest that cannabinoids may be a useful therapeutic approach for the clinical management of trigeminal neuropathic pain disorders. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/17572451/The_synthetic_cannabinoids_attenuate_allodynia_and_hyperalgesia_in_a_rat_model_of_trigeminal_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(07)00125-6 DB - PRIME DP - Unbound Medicine ER -