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Primary Ewing's sarcoma-primitive neuroectodermal tumor of the uterus: a case report and literature review.
Gynecol Oncol. 2007 Aug; 106(2):427-32.GO

Abstract

BACKGROUND

Primary Ewing's sarcoma-primitive neuroectodermal tumor (ES-PNET) of the uterus is an extremely rare malignancy.

CASE

A 30-year-old Korean woman presented with abnormal uterine bleeding with uterine enlargement. A computed tomography (CT) scan and magnetic resonance imaging (MRI) of the abdomen and pelvis showed a huge uterine mass measuring 18 x 20 x 21 cm, metastasis to both pelvic and para-aortic lymph nodes, and omental infiltration. The pathology report of the uterine mass described a uniformly hypercellular tumor, which was arranged in diffuse solid sheets of uniform, small, rounded, and sometimes spindle-shaped cells, with scanty cytoplasm. Immunohistochemically, the mass tested positive for vimentin, CD99, and chromogranin. The patient received several courses of combination chemotherapy and radiotherapy but died from tumor progression 16 months after the initial diagnosis.

CONCLUSION(S)

This is a rare case of primary uterine ES-PNET in a woman of reproductive age. A review of the literature indicates that primary uterine ES-PNET requires early diagnosis and multimodality treatment including surgery, chemotherapy, and radiotherapy. The behavior of this tumor is potentially aggressive.

Authors+Show Affiliations

Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 411-351, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17572479

Citation

Park, Jeong-Yeol, et al. "Primary Ewing's Sarcoma-primitive Neuroectodermal Tumor of the Uterus: a Case Report and Literature Review." Gynecologic Oncology, vol. 106, no. 2, 2007, pp. 427-32.
Park JY, Lee S, Kang HJ, et al. Primary Ewing's sarcoma-primitive neuroectodermal tumor of the uterus: a case report and literature review. Gynecol Oncol. 2007;106(2):427-32.
Park, J. Y., Lee, S., Kang, H. J., Kim, H. S., & Park, S. Y. (2007). Primary Ewing's sarcoma-primitive neuroectodermal tumor of the uterus: a case report and literature review. Gynecologic Oncology, 106(2), 427-32.
Park JY, et al. Primary Ewing's Sarcoma-primitive Neuroectodermal Tumor of the Uterus: a Case Report and Literature Review. Gynecol Oncol. 2007;106(2):427-32. PubMed PMID: 17572479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary Ewing's sarcoma-primitive neuroectodermal tumor of the uterus: a case report and literature review. AU - Park,Jeong-Yeol, AU - Lee,Sun, AU - Kang,Hyoung Jin, AU - Kim,Hy-Sook, AU - Park,Sang-Yoon, Y1 - 2007/06/18/ PY - 2007/01/17/received PY - 2007/04/06/revised PY - 2007/04/06/accepted PY - 2007/6/19/pubmed PY - 2007/9/7/medline PY - 2007/6/19/entrez SP - 427 EP - 32 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 106 IS - 2 N2 - BACKGROUND: Primary Ewing's sarcoma-primitive neuroectodermal tumor (ES-PNET) of the uterus is an extremely rare malignancy. CASE: A 30-year-old Korean woman presented with abnormal uterine bleeding with uterine enlargement. A computed tomography (CT) scan and magnetic resonance imaging (MRI) of the abdomen and pelvis showed a huge uterine mass measuring 18 x 20 x 21 cm, metastasis to both pelvic and para-aortic lymph nodes, and omental infiltration. The pathology report of the uterine mass described a uniformly hypercellular tumor, which was arranged in diffuse solid sheets of uniform, small, rounded, and sometimes spindle-shaped cells, with scanty cytoplasm. Immunohistochemically, the mass tested positive for vimentin, CD99, and chromogranin. The patient received several courses of combination chemotherapy and radiotherapy but died from tumor progression 16 months after the initial diagnosis. CONCLUSION(S): This is a rare case of primary uterine ES-PNET in a woman of reproductive age. A review of the literature indicates that primary uterine ES-PNET requires early diagnosis and multimodality treatment including surgery, chemotherapy, and radiotherapy. The behavior of this tumor is potentially aggressive. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/17572479/Primary_Ewing's_sarcoma_primitive_neuroectodermal_tumor_of_the_uterus:_a_case_report_and_literature_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(07)00265-X DB - PRIME DP - Unbound Medicine ER -