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Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms.
Allergy 2007; 62(7):738-43A

Abstract

BACKGROUND

Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined.

PATIENTS AND METHODS

We evaluated the diagnostic accuracy of food challenge, skin prick test (SPT), serum specific IgE determination, and APT using fresh food and commercial food extracts in parallel in children referred for suspected food allergy-related gastrointestinal symptoms.

RESULTS

Eighty-nine food challenges were performed in 60 patients (38 boys, median age 23 months, range 3-48 months): 31 tested positive for cow's milk (CM), 19 for hen's egg (HE), and two for wheat. Specific immunoglobulin E (IgE) determination, and SPT, respectively, were positive in 7/31 and 14/31 of patients with cow's milk allergy (CMA), and in 7/19 and 7/19 with HE allergy. The results of APT with fresh food vs a commercial assay were (1) CM: sensitivity: 64.5%vs 6.4%, specificity 95.8%vs 95.6%, positive predictive value (PPV) 95.2%vs 66.6% and negative predictive value (NPV) 67.6%vs 43.1%; (2) HE: sensitivity 84.2%vs 5.2%, specificity 100%vs 100%, PPV 100%vs 100% and NPV 75.0%vs 33.3%.

CONCLUSIONS

Atopy patch test is a useful tool in the diagnostic work up of children with food-allergy-related gastrointestinal symptoms. The diagnostic accuracy of ATP was higher with fresh food than with commercial food extracts.

Authors+Show Affiliations

Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17573720

Citation

Canani, R Berni, et al. "Diagnostic Accuracy of the Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms." Allergy, vol. 62, no. 7, 2007, pp. 738-43.
Canani RB, Ruotolo S, Auricchio L, et al. Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. Allergy. 2007;62(7):738-43.
Canani, R. B., Ruotolo, S., Auricchio, L., Caldore, M., Porcaro, F., Manguso, F., ... Troncone, R. (2007). Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. Allergy, 62(7), pp. 738-43.
Canani RB, et al. Diagnostic Accuracy of the Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms. Allergy. 2007;62(7):738-43. PubMed PMID: 17573720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. AU - Canani,R Berni, AU - Ruotolo,S, AU - Auricchio,L, AU - Caldore,M, AU - Porcaro,F, AU - Manguso,F, AU - Terrin,G, AU - Troncone,R, PY - 2007/6/19/pubmed PY - 2007/9/6/medline PY - 2007/6/19/entrez SP - 738 EP - 43 JF - Allergy JO - Allergy VL - 62 IS - 7 N2 - BACKGROUND: Little is known about the diagnostic accuracy of atopy patch tests (APT) in the clinical practice of pediatric gastroenterology. Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined. PATIENTS AND METHODS: We evaluated the diagnostic accuracy of food challenge, skin prick test (SPT), serum specific IgE determination, and APT using fresh food and commercial food extracts in parallel in children referred for suspected food allergy-related gastrointestinal symptoms. RESULTS: Eighty-nine food challenges were performed in 60 patients (38 boys, median age 23 months, range 3-48 months): 31 tested positive for cow's milk (CM), 19 for hen's egg (HE), and two for wheat. Specific immunoglobulin E (IgE) determination, and SPT, respectively, were positive in 7/31 and 14/31 of patients with cow's milk allergy (CMA), and in 7/19 and 7/19 with HE allergy. The results of APT with fresh food vs a commercial assay were (1) CM: sensitivity: 64.5%vs 6.4%, specificity 95.8%vs 95.6%, positive predictive value (PPV) 95.2%vs 66.6% and negative predictive value (NPV) 67.6%vs 43.1%; (2) HE: sensitivity 84.2%vs 5.2%, specificity 100%vs 100%, PPV 100%vs 100% and NPV 75.0%vs 33.3%. CONCLUSIONS: Atopy patch test is a useful tool in the diagnostic work up of children with food-allergy-related gastrointestinal symptoms. The diagnostic accuracy of ATP was higher with fresh food than with commercial food extracts. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/17573720/Diagnostic_accuracy_of_the_atopy_patch_test_in_children_with_food_allergy_related_gastrointestinal_symptoms_ L2 - https://doi.org/10.1111/j.1398-9995.2007.01351.x DB - PRIME DP - Unbound Medicine ER -