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Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome.
J Urol. 2007 Jul; 178(1):51-6.JU

Abstract

PURPOSE

Squamous cell carcinomas of the renal pelvis and ureter are rare. We report a large series of patients and compare it to patients with urothelial carcinoma.

MATERIALS AND METHODS

The initial material was comprised of 808 patients with renal pelvis or ureteral cancer. A review of the histopathological material and clinical records was performed.

RESULTS

Only 2 (4%) of 65 patients with squamous cell carcinoma had stage pTa/pT1/pT2 tumors compared to 460 (62%) of 743 patients with urothelial carcinoma. Median survival was much shorter for surgically treated patients with squamous cell carcinoma compared to those with urothelial carcinoma (7 vs 50 months). However, there was no significant difference in the disease specific 5-year survival rate between patients with squamous cell carcinoma and urothelial carcinoma in the same disease stage. Vascular invasion, microscopic solid tumor pattern and large tumor size had negative prognostic significance in multivariate analyses. Histopathological tumor type (squamous cell carcinoma or urothelial carcinoma) had no prognostic significance.

CONCLUSIONS

The prognosis for squamous cell carcinoma is poor, but stage for stage the prognosis is not different between patients with urothelial carcinoma and squamous cell carcinoma of the renal pelvis and ureter. It can be presumed that high stage squamous cell carcinoma and urothelial carcinoma become symptomatic first at a time when the tumors already are large, deeply invasive and most often incurable. New treatment modalities are urgently needed to improve the poor prognosis in patients with advanced stage squamous cell carcinoma and urothelial carcinoma of the upper urinary tract.

Authors+Show Affiliations

Department of Urology, Sahlgrenska University Hospital Göteborg, Sweden. sten.holmang@telia.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17574059

Citation

Holmäng, Sten, et al. "Squamous Cell Carcinoma of the Renal Pelvis and Ureter: Incidence, Symptoms, Treatment and Outcome." The Journal of Urology, vol. 178, no. 1, 2007, pp. 51-6.
Holmäng S, Lele SM, Johansson SL. Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome. J Urol. 2007;178(1):51-6.
Holmäng, S., Lele, S. M., & Johansson, S. L. (2007). Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome. The Journal of Urology, 178(1), 51-6.
Holmäng S, Lele SM, Johansson SL. Squamous Cell Carcinoma of the Renal Pelvis and Ureter: Incidence, Symptoms, Treatment and Outcome. J Urol. 2007;178(1):51-6. PubMed PMID: 17574059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome. AU - Holmäng,Sten, AU - Lele,Subodh M, AU - Johansson,Sonny L, Y1 - 2007/05/11/ PY - 2006/11/13/received PY - 2007/6/19/pubmed PY - 2007/7/18/medline PY - 2007/6/19/entrez SP - 51 EP - 6 JF - The Journal of urology JO - J Urol VL - 178 IS - 1 N2 - PURPOSE: Squamous cell carcinomas of the renal pelvis and ureter are rare. We report a large series of patients and compare it to patients with urothelial carcinoma. MATERIALS AND METHODS: The initial material was comprised of 808 patients with renal pelvis or ureteral cancer. A review of the histopathological material and clinical records was performed. RESULTS: Only 2 (4%) of 65 patients with squamous cell carcinoma had stage pTa/pT1/pT2 tumors compared to 460 (62%) of 743 patients with urothelial carcinoma. Median survival was much shorter for surgically treated patients with squamous cell carcinoma compared to those with urothelial carcinoma (7 vs 50 months). However, there was no significant difference in the disease specific 5-year survival rate between patients with squamous cell carcinoma and urothelial carcinoma in the same disease stage. Vascular invasion, microscopic solid tumor pattern and large tumor size had negative prognostic significance in multivariate analyses. Histopathological tumor type (squamous cell carcinoma or urothelial carcinoma) had no prognostic significance. CONCLUSIONS: The prognosis for squamous cell carcinoma is poor, but stage for stage the prognosis is not different between patients with urothelial carcinoma and squamous cell carcinoma of the renal pelvis and ureter. It can be presumed that high stage squamous cell carcinoma and urothelial carcinoma become symptomatic first at a time when the tumors already are large, deeply invasive and most often incurable. New treatment modalities are urgently needed to improve the poor prognosis in patients with advanced stage squamous cell carcinoma and urothelial carcinoma of the upper urinary tract. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/17574059/Squamous_cell_carcinoma_of_the_renal_pelvis_and_ureter:_incidence_symptoms_treatment_and_outcome_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2007.03.033?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -