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Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.
J Chromatogr A. 2007 Aug 17; 1161(1-2):170-82.JC

Abstract

By using HPLC-diode array detection-electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)) in negative ion mode, we have analyzed the fragmentation pathways of 11 phenolic acids which were isolated from Danshen. Then the extract of Danshen was analyzed, and a total of 42 phenolic acids, including sixteen new minor constituents, were identified or tentatively identified for the first time. A new solid-phase extraction (SPE) method, new HPLC separation method, new liquid chromatography (LC)-MS and LC-MS(n) (n=3-5) data and proposed fragmentation pathways, LC retention time for phenolic acids are reported.

Authors+Show Affiliations

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17574558

Citation

Liu, Ai-Hua, et al. "Detection, Characterization and Identification of Phenolic Acids in Danshen Using High-performance Liquid Chromatography With Diode Array Detection and Electrospray Ionization Mass Spectrometry." Journal of Chromatography. A, vol. 1161, no. 1-2, 2007, pp. 170-82.
Liu AH, Guo H, Ye M, et al. Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. J Chromatogr A. 2007;1161(1-2):170-82.
Liu, A. H., Guo, H., Ye, M., Lin, Y. H., Sun, J. H., Xu, M., & Guo, D. A. (2007). Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. Journal of Chromatography. A, 1161(1-2), 170-82.
Liu AH, et al. Detection, Characterization and Identification of Phenolic Acids in Danshen Using High-performance Liquid Chromatography With Diode Array Detection and Electrospray Ionization Mass Spectrometry. J Chromatogr A. 2007 Aug 17;1161(1-2):170-82. PubMed PMID: 17574558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. AU - Liu,Ai-Hua, AU - Guo,Hui, AU - Ye,Min, AU - Lin,Yan-Hua, AU - Sun,Jiang-Hao, AU - Xu,Man, AU - Guo,De-An, Y1 - 2007/05/31/ PY - 2006/09/25/received PY - 2007/05/18/revised PY - 2007/05/24/accepted PY - 2007/6/19/pubmed PY - 2007/10/2/medline PY - 2007/6/19/entrez SP - 170 EP - 82 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1161 IS - 1-2 N2 - By using HPLC-diode array detection-electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)) in negative ion mode, we have analyzed the fragmentation pathways of 11 phenolic acids which were isolated from Danshen. Then the extract of Danshen was analyzed, and a total of 42 phenolic acids, including sixteen new minor constituents, were identified or tentatively identified for the first time. A new solid-phase extraction (SPE) method, new HPLC separation method, new liquid chromatography (LC)-MS and LC-MS(n) (n=3-5) data and proposed fragmentation pathways, LC retention time for phenolic acids are reported. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/17574558/Detection_characterization_and_identification_of_phenolic_acids_in_Danshen_using_high_performance_liquid_chromatography_with_diode_array_detection_and_electrospray_ionization_mass_spectrometry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(07)00986-7 DB - PRIME DP - Unbound Medicine ER -