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Relating imaging indices of white matter integrity and volume in healthy older adults.

Abstract

Age-related alterations in white matter have the potential to profoundly affect cognitive functioning. In fact, magnetic resonance imaging (MRI) studies using fractional anisotropy (FA) to measure white matter integrity reveal a positive correlation between FA and behavioral performance in older adults. Confounding these results are imaging studies demonstrating age-related white matter atrophy in some areas displaying altered FA, suggesting changes in diffusion may be simply an epiphenomenon of tissue loss. In the current study, structural MRI techniques were used to identify the relationship between white matter integrity and decreased volume in healthy aging adults. The data demonstrated that white matter atrophy did in fact account for differences in some areas, but significant FA decreases remained across much of the white matter after adjusting for atrophy. Results suggest a complex relationship between changes in white matter integrity and volume. FA appears to be more sensitive than volume loss to changes in normal appearing tissue, and these FA changes may actually precede white matter atrophy in some brain areas. As such, the ability to detect early white matter alterations may facilitate development of targeted treatments that prevent or slow age-related white matter degradation and associated cognitive sequelae.

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  • Authors+Show Affiliations

    ,

    Neuroscience Program, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. chugensc@wfubmc.edu

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Aging
    Brain
    Female
    Humans
    Image Interpretation, Computer-Assisted
    Imaging, Three-Dimensional
    Middle Aged
    Nerve Fibers, Myelinated
    Organ Size

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17575289

    Citation

    Hugenschmidt, Christina E., et al. "Relating Imaging Indices of White Matter Integrity and Volume in Healthy Older Adults." Cerebral Cortex (New York, N.Y. : 1991), vol. 18, no. 2, 2008, pp. 433-42.
    Hugenschmidt CE, Peiffer AM, Kraft RA, et al. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008;18(2):433-42.
    Hugenschmidt, C. E., Peiffer, A. M., Kraft, R. A., Casanova, R., Deibler, A. R., Burdette, J. H., ... Laurienti, P. J. (2008). Relating imaging indices of white matter integrity and volume in healthy older adults. Cerebral Cortex (New York, N.Y. : 1991), 18(2), pp. 433-42.
    Hugenschmidt CE, et al. Relating Imaging Indices of White Matter Integrity and Volume in Healthy Older Adults. Cereb Cortex. 2008;18(2):433-42. PubMed PMID: 17575289.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relating imaging indices of white matter integrity and volume in healthy older adults. AU - Hugenschmidt,Christina E, AU - Peiffer,Ann M, AU - Kraft,Robert A, AU - Casanova,Ramon, AU - Deibler,Andrew R, AU - Burdette,Jonathan H, AU - Maldjian,Joseph A, AU - Laurienti,Paul J, Y1 - 2007/06/16/ PY - 2007/6/19/pubmed PY - 2008/2/20/medline PY - 2007/6/19/entrez SP - 433 EP - 42 JF - Cerebral cortex (New York, N.Y. : 1991) JO - Cereb. Cortex VL - 18 IS - 2 N2 - Age-related alterations in white matter have the potential to profoundly affect cognitive functioning. In fact, magnetic resonance imaging (MRI) studies using fractional anisotropy (FA) to measure white matter integrity reveal a positive correlation between FA and behavioral performance in older adults. Confounding these results are imaging studies demonstrating age-related white matter atrophy in some areas displaying altered FA, suggesting changes in diffusion may be simply an epiphenomenon of tissue loss. In the current study, structural MRI techniques were used to identify the relationship between white matter integrity and decreased volume in healthy aging adults. The data demonstrated that white matter atrophy did in fact account for differences in some areas, but significant FA decreases remained across much of the white matter after adjusting for atrophy. Results suggest a complex relationship between changes in white matter integrity and volume. FA appears to be more sensitive than volume loss to changes in normal appearing tissue, and these FA changes may actually precede white matter atrophy in some brain areas. As such, the ability to detect early white matter alterations may facilitate development of targeted treatments that prevent or slow age-related white matter degradation and associated cognitive sequelae. SN - 1460-2199 UR - https://www.unboundmedicine.com/medline/citation/17575289/Relating_imaging_indices_of_white_matter_integrity_and_volume_in_healthy_older_adults_ L2 - https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhm080 DB - PRIME DP - Unbound Medicine ER -