Tags

Type your tag names separated by a space and hit enter

Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine.
Vaccine. 2007 Jul 20; 25(29):5278-82.V

Abstract

OBJECTIVE

Asplenic children are at high risk of invasive pneumococcal infection. In this group, the American Academy of Pediatrics recommends a single revaccination with the 23-valent polysaccharide vaccine (PSV23) 3-5 years after a previous PSV23 dose. Despite potential advantages, there are few data available regarding the safety and immunogenicity of the heptavalent pneumococcal conjugate vaccine (PCV7) in this population. The aim of the study was to prospectively determine and to compare, in asplenic children, the vaccine specific antibody titres against the seven serotypes included in the PCV7 after administration of one dose of PCV7 or of PSV23, 3 years or more after an initial vaccination with PSV23.

PATIENTS AND METHODS

In this randomised, single-centre study, antibody titres were monitored at baseline, at 1 and 6 months after revaccination in 21 children with anatomic or functional asplenia. Response was considered as positive when there was a four-fold increase in antibody titres from baseline.

RESULTS

The most frequently reported adverse events were local reactions in 7/11 of PCV7 subjects and in 5/8 of PSV23 subjects, and general reactions (loss of appetite, sleepiness) in 5/11 of PCV7 subjects and in 1/8 of PSV23 subjects; without any serious adverse events. One child in the PCV7 group had increased temperature (38.4 degrees C). At least half of the PCV7 children responded to four or five serotypes, while more than half of the PSV23 subjects responded to less than 3 serotypes (p=0.285). After 1 month, the immune response for serotype 23F was significantly greater after PCV7 vaccination than after PSV23 vaccination (p=0.036).

CONCLUSIONS

PCV7 revaccination is safe and immunogenic in asplenic children previously vaccinated with PSV23, and could provide appropriate booster response in this high-risk population. The clinical repercussion on invasive pneumococcal diseases remains to be demonstrated.

Authors+Show Affiliations

Paediatric Clinical Investigation Centre, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. francoise.smets@pedi.ucl.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17576024

Citation

Smets, F, et al. "Randomised Revaccination With Pneumococcal Polysaccharide or Conjugate Vaccine in Asplenic Children Previously Vaccinated With Polysaccharide Vaccine." Vaccine, vol. 25, no. 29, 2007, pp. 5278-82.
Smets F, Bourgois A, Vermylen C, et al. Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine. Vaccine. 2007;25(29):5278-82.
Smets, F., Bourgois, A., Vermylen, C., Brichard, B., Slacmuylders, P., Leyman, S., & Sokal, E. (2007). Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine. Vaccine, 25(29), 5278-82.
Smets F, et al. Randomised Revaccination With Pneumococcal Polysaccharide or Conjugate Vaccine in Asplenic Children Previously Vaccinated With Polysaccharide Vaccine. Vaccine. 2007 Jul 20;25(29):5278-82. PubMed PMID: 17576024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomised revaccination with pneumococcal polysaccharide or conjugate vaccine in asplenic children previously vaccinated with polysaccharide vaccine. AU - Smets,F, AU - Bourgois,A, AU - Vermylen,C, AU - Brichard,B, AU - Slacmuylders,P, AU - Leyman,S, AU - Sokal,E, Y1 - 2007/06/04/ PY - 2006/11/08/received PY - 2007/04/16/revised PY - 2007/05/13/accepted PY - 2007/6/20/pubmed PY - 2007/9/12/medline PY - 2007/6/20/entrez SP - 5278 EP - 82 JF - Vaccine JO - Vaccine VL - 25 IS - 29 N2 - OBJECTIVE: Asplenic children are at high risk of invasive pneumococcal infection. In this group, the American Academy of Pediatrics recommends a single revaccination with the 23-valent polysaccharide vaccine (PSV23) 3-5 years after a previous PSV23 dose. Despite potential advantages, there are few data available regarding the safety and immunogenicity of the heptavalent pneumococcal conjugate vaccine (PCV7) in this population. The aim of the study was to prospectively determine and to compare, in asplenic children, the vaccine specific antibody titres against the seven serotypes included in the PCV7 after administration of one dose of PCV7 or of PSV23, 3 years or more after an initial vaccination with PSV23. PATIENTS AND METHODS: In this randomised, single-centre study, antibody titres were monitored at baseline, at 1 and 6 months after revaccination in 21 children with anatomic or functional asplenia. Response was considered as positive when there was a four-fold increase in antibody titres from baseline. RESULTS: The most frequently reported adverse events were local reactions in 7/11 of PCV7 subjects and in 5/8 of PSV23 subjects, and general reactions (loss of appetite, sleepiness) in 5/11 of PCV7 subjects and in 1/8 of PSV23 subjects; without any serious adverse events. One child in the PCV7 group had increased temperature (38.4 degrees C). At least half of the PCV7 children responded to four or five serotypes, while more than half of the PSV23 subjects responded to less than 3 serotypes (p=0.285). After 1 month, the immune response for serotype 23F was significantly greater after PCV7 vaccination than after PSV23 vaccination (p=0.036). CONCLUSIONS: PCV7 revaccination is safe and immunogenic in asplenic children previously vaccinated with PSV23, and could provide appropriate booster response in this high-risk population. The clinical repercussion on invasive pneumococcal diseases remains to be demonstrated. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/17576024/Randomised_revaccination_with_pneumococcal_polysaccharide_or_conjugate_vaccine_in_asplenic_children_previously_vaccinated_with_polysaccharide_vaccine_ DB - PRIME DP - Unbound Medicine ER -