Tags

Type your tag names separated by a space and hit enter

Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris.
Exp Dermatol. 2007 Jul; 16(7):547-52.ED

Abstract

Central or peripheral stress may induce the development of clinical inflammation in the pilosebaceous unit, leading to the development of acne lesions or to exacerbation of pre-existing acne. Melanocortin peptides such as alpha-melanocyte-stimulating hormone and its receptors do not only regulate melanogenesis but can also affect non-pigmentary processes, such as inflammation, apoptosis and sebogenesis. The purpose of the study was to investigate by immunohistochemistry if changes of melanocortin-1 receptor expression exist in acne lesions versus normal skin. In all, 33 patients with acne vulgaris and seven age-matched volunteers without acne participated in the study. Skin biopsies were taken from acne-involved faces, the non-involved thigh skin of the same patients and from normal human skin. Melanocortin-1 receptor immunoreactivity was most prominently detectable in adnexal structures. Sebocytes and keratinocytes of the ductus seboglandularis of acne-involved and non-involved skin showed very intense melanocortin-1 receptor expression in contrast to less intense scattered immunoreactivity in normal skin samples. These data suggest that melanocortin-1 receptor is involved in the pathogenesis of acne.

Authors+Show Affiliations

Centre of Dermatovenereology, Vilnius University Hospital, Santariskiu Klinikos, Vilnius, Lithuania.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17576233

Citation

Ganceviciene, Ruta, et al. "Increased in Situ Expression of Melanocortin-1 Receptor in Sebaceous Glands of Lesional Skin of Patients With Acne Vulgaris." Experimental Dermatology, vol. 16, no. 7, 2007, pp. 547-52.
Ganceviciene R, Graziene V, Böhm M, et al. Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. Exp Dermatol. 2007;16(7):547-52.
Ganceviciene, R., Graziene, V., Böhm, M., & Zouboulis, C. C. (2007). Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. Experimental Dermatology, 16(7), 547-52.
Ganceviciene R, et al. Increased in Situ Expression of Melanocortin-1 Receptor in Sebaceous Glands of Lesional Skin of Patients With Acne Vulgaris. Exp Dermatol. 2007;16(7):547-52. PubMed PMID: 17576233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased in situ expression of melanocortin-1 receptor in sebaceous glands of lesional skin of patients with acne vulgaris. AU - Ganceviciene,Ruta, AU - Graziene,Vida, AU - Böhm,Markus, AU - Zouboulis,Christos C, PY - 2007/6/20/pubmed PY - 2007/9/1/medline PY - 2007/6/20/entrez SP - 547 EP - 52 JF - Experimental dermatology JO - Exp. Dermatol. VL - 16 IS - 7 N2 - Central or peripheral stress may induce the development of clinical inflammation in the pilosebaceous unit, leading to the development of acne lesions or to exacerbation of pre-existing acne. Melanocortin peptides such as alpha-melanocyte-stimulating hormone and its receptors do not only regulate melanogenesis but can also affect non-pigmentary processes, such as inflammation, apoptosis and sebogenesis. The purpose of the study was to investigate by immunohistochemistry if changes of melanocortin-1 receptor expression exist in acne lesions versus normal skin. In all, 33 patients with acne vulgaris and seven age-matched volunteers without acne participated in the study. Skin biopsies were taken from acne-involved faces, the non-involved thigh skin of the same patients and from normal human skin. Melanocortin-1 receptor immunoreactivity was most prominently detectable in adnexal structures. Sebocytes and keratinocytes of the ductus seboglandularis of acne-involved and non-involved skin showed very intense melanocortin-1 receptor expression in contrast to less intense scattered immunoreactivity in normal skin samples. These data suggest that melanocortin-1 receptor is involved in the pathogenesis of acne. SN - 0906-6705 UR - https://www.unboundmedicine.com/medline/citation/17576233/Increased_in_situ_expression_of_melanocortin_1_receptor_in_sebaceous_glands_of_lesional_skin_of_patients_with_acne_vulgaris_ L2 - https://doi.org/10.1111/j.1600-0625.2007.00565.x DB - PRIME DP - Unbound Medicine ER -