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[Clinical study on the correlation between high sensitivity C-reactive protein and risk factors in cerebral vessel [corrected] disease].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Jun; 19(6):325-8.ZW

Abstract

OBJECTIVE

To investigate correlation between high sensitivity C-reactive protein (hs-CRP) and risk factors of acute stroke and cerebrovascular disease.

METHODS

Hs-CRP levels were determined in 118 hypertensive patients with acute stroke (86 patients with cerebral infarction and 32 patients with cerebral hemorrhage) and in 67 healthy volunteers as normal control group by scattered radiation immunoturbidimetry. The difference in hs-CRP was analyzed in these two groups, and the correlation between hs-CRP and the cerebrovascular disease risk factors were analyzed.

RESULTS

Acute stroke patients had a significantly higher level of hs-CRP compared with healthy subjects (P<0.01). There was no significant difference of hs-CRP level between cerebral infarction group and cerebral hemorrhage group. Hs-CRP level was significantly correlated with cerebrovascular accident risks such as age, body mass index (BMI), abdominal circumference, systolic and diastolic pressure, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and serum fasting blood glucose by Pearson correlation analysis (P<0.05 or P<0.01), and strong positive correlations were observed between the hs-CRP level and systolic pressure, the serum fasting blood glucose, total cholesterol, triglycerides, LDL-C and HDL-C by analysis using the multivariate stepwise regression model (all P<0.01).

CONCLUSION

The high level hs-CRP is in close relation with acute stroke, and blood pressure, serum fasting blood glucose and cholesterol are significant and independent risk factors that might influence the level of hs-CRP.

Authors+Show Affiliations

Department of Emergency, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17577433

Citation

Zhou, Wei-jun, et al. "[Clinical Study On the Correlation Between High Sensitivity C-reactive Protein and Risk Factors in Cerebral Vessel [corrected] Disease]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 19, no. 6, 2007, pp. 325-8.
Zhou WJ, Tong JJ, Ye J, et al. [Clinical study on the correlation between high sensitivity C-reactive protein and risk factors in cerebral vessel [corrected] disease]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007;19(6):325-8.
Zhou, W. J., Tong, J. J., Ye, J., & Lu, Y. M. (2007). [Clinical study on the correlation between high sensitivity C-reactive protein and risk factors in cerebral vessel [corrected] disease]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 19(6), 325-8.
Zhou WJ, et al. [Clinical Study On the Correlation Between High Sensitivity C-reactive Protein and Risk Factors in Cerebral Vessel [corrected] Disease]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007;19(6):325-8. PubMed PMID: 17577433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical study on the correlation between high sensitivity C-reactive protein and risk factors in cerebral vessel [corrected] disease]. AU - Zhou,Wei-jun, AU - Tong,Jian-jing, AU - Ye,Jing, AU - Lu,Yi-ming, PY - 2007/6/20/pubmed PY - 2009/7/10/medline PY - 2007/6/20/entrez SP - 325 EP - 8 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 19 IS - 6 N2 - OBJECTIVE: To investigate correlation between high sensitivity C-reactive protein (hs-CRP) and risk factors of acute stroke and cerebrovascular disease. METHODS: Hs-CRP levels were determined in 118 hypertensive patients with acute stroke (86 patients with cerebral infarction and 32 patients with cerebral hemorrhage) and in 67 healthy volunteers as normal control group by scattered radiation immunoturbidimetry. The difference in hs-CRP was analyzed in these two groups, and the correlation between hs-CRP and the cerebrovascular disease risk factors were analyzed. RESULTS: Acute stroke patients had a significantly higher level of hs-CRP compared with healthy subjects (P<0.01). There was no significant difference of hs-CRP level between cerebral infarction group and cerebral hemorrhage group. Hs-CRP level was significantly correlated with cerebrovascular accident risks such as age, body mass index (BMI), abdominal circumference, systolic and diastolic pressure, serum total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and serum fasting blood glucose by Pearson correlation analysis (P<0.05 or P<0.01), and strong positive correlations were observed between the hs-CRP level and systolic pressure, the serum fasting blood glucose, total cholesterol, triglycerides, LDL-C and HDL-C by analysis using the multivariate stepwise regression model (all P<0.01). CONCLUSION: The high level hs-CRP is in close relation with acute stroke, and blood pressure, serum fasting blood glucose and cholesterol are significant and independent risk factors that might influence the level of hs-CRP. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/17577433/[Clinical_study_on_the_correlation_between_high_sensitivity_C_reactive_protein_and_risk_factors_in_cerebral_vessel_[corrected]_disease]_ L2 - https://medlineplus.gov/stroke.html DB - PRIME DP - Unbound Medicine ER -
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