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Migraine comorbidity constellations.
Headache. 2007 Jun; 47(6):857-65.H

Abstract

OBJECTIVES

To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences in demographics, headache profiles, and psychosocial features between the comorbidity constellations.

METHODS

This is a retrospective electronic chart review of consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification of Headache Disorders (ICHD)-II criteria. Questionnaire collected information on comorbid diagnoses, current depression, somatic symptoms, psychosocial stressors, and antidepressant use, social and abuse history. Cluster analysis, based on nonheadache disorders, was performed and differences between the resulting groups were examined.

RESULTS

We identified 3 groups. Group 1 (n = 55) was defined by hypertension, hyperlipidemia, diabetes mellitus, and hypothyroidism; Group 2 (n = 83) by depression, anxiety, and fibromyalgia; Group 3 (n = 85) by the absence of defining comorbidities. Group 1 had more males (22% vs 5% vs 12%, P < .05), was older (median years: 52 vs 36 vs 32, P < .01), and had later age of headache onset (median years: 22 vs 16 vs 18, P < .05). Group 2 had the greatest disability (P < .05), and the lowest quality of life (P < .001). Persons in Group 2 more commonly reported sexual abuse (OR = 2.7, 95% CI: 1.1 to 6.5), physical abuse (OR = 2.5, 95% CI: 1.2 to 5.1), and emotional abuse (OR = 4.3, 95% CI: 1.9 to 8.9).

CONCLUSION

Within a headache clinic population, we identified 3 different migraine comorbidity constellations, with differing headache and psychosocial profiles, suggesting heterogeneity of genetic and environmental factors. This may have implications for diagnosis and disease management.

Authors+Show Affiliations

Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17578536

Citation

Tietjen, Gretchen E., et al. "Migraine Comorbidity Constellations." Headache, vol. 47, no. 6, 2007, pp. 857-65.
Tietjen GE, Herial NA, Hardgrove J, et al. Migraine comorbidity constellations. Headache. 2007;47(6):857-65.
Tietjen, G. E., Herial, N. A., Hardgrove, J., Utley, C., & White, L. (2007). Migraine comorbidity constellations. Headache, 47(6), 857-65.
Tietjen GE, et al. Migraine Comorbidity Constellations. Headache. 2007;47(6):857-65. PubMed PMID: 17578536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Migraine comorbidity constellations. AU - Tietjen,Gretchen E, AU - Herial,Nabeel A, AU - Hardgrove,Jacqueline, AU - Utley,Christine, AU - White,Leah, PY - 2007/6/21/pubmed PY - 2007/8/2/medline PY - 2007/6/21/entrez SP - 857 EP - 65 JF - Headache JO - Headache VL - 47 IS - 6 N2 - OBJECTIVES: To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences in demographics, headache profiles, and psychosocial features between the comorbidity constellations. METHODS: This is a retrospective electronic chart review of consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification of Headache Disorders (ICHD)-II criteria. Questionnaire collected information on comorbid diagnoses, current depression, somatic symptoms, psychosocial stressors, and antidepressant use, social and abuse history. Cluster analysis, based on nonheadache disorders, was performed and differences between the resulting groups were examined. RESULTS: We identified 3 groups. Group 1 (n = 55) was defined by hypertension, hyperlipidemia, diabetes mellitus, and hypothyroidism; Group 2 (n = 83) by depression, anxiety, and fibromyalgia; Group 3 (n = 85) by the absence of defining comorbidities. Group 1 had more males (22% vs 5% vs 12%, P < .05), was older (median years: 52 vs 36 vs 32, P < .01), and had later age of headache onset (median years: 22 vs 16 vs 18, P < .05). Group 2 had the greatest disability (P < .05), and the lowest quality of life (P < .001). Persons in Group 2 more commonly reported sexual abuse (OR = 2.7, 95% CI: 1.1 to 6.5), physical abuse (OR = 2.5, 95% CI: 1.2 to 5.1), and emotional abuse (OR = 4.3, 95% CI: 1.9 to 8.9). CONCLUSION: Within a headache clinic population, we identified 3 different migraine comorbidity constellations, with differing headache and psychosocial profiles, suggesting heterogeneity of genetic and environmental factors. This may have implications for diagnosis and disease management. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/17578536/Migraine_comorbidity_constellations_ L2 - https://doi.org/10.1111/j.1526-4610.2007.00814.x DB - PRIME DP - Unbound Medicine ER -