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Migraine comorbidity constellations.

Abstract

OBJECTIVES

To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences in demographics, headache profiles, and psychosocial features between the comorbidity constellations.

METHODS

This is a retrospective electronic chart review of consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification of Headache Disorders (ICHD)-II criteria. Questionnaire collected information on comorbid diagnoses, current depression, somatic symptoms, psychosocial stressors, and antidepressant use, social and abuse history. Cluster analysis, based on nonheadache disorders, was performed and differences between the resulting groups were examined.

RESULTS

We identified 3 groups. Group 1 (n = 55) was defined by hypertension, hyperlipidemia, diabetes mellitus, and hypothyroidism; Group 2 (n = 83) by depression, anxiety, and fibromyalgia; Group 3 (n = 85) by the absence of defining comorbidities. Group 1 had more males (22% vs 5% vs 12%, P < .05), was older (median years: 52 vs 36 vs 32, P < .01), and had later age of headache onset (median years: 22 vs 16 vs 18, P < .05). Group 2 had the greatest disability (P < .05), and the lowest quality of life (P < .001). Persons in Group 2 more commonly reported sexual abuse (OR = 2.7, 95% CI: 1.1 to 6.5), physical abuse (OR = 2.5, 95% CI: 1.2 to 5.1), and emotional abuse (OR = 4.3, 95% CI: 1.9 to 8.9).

CONCLUSION

Within a headache clinic population, we identified 3 different migraine comorbidity constellations, with differing headache and psychosocial profiles, suggesting heterogeneity of genetic and environmental factors. This may have implications for diagnosis and disease management.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614, USA.

    , , ,

    Source

    Headache 47:6 2007 Jun pg 857-65

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Anxiety
    Asthma
    Cardiovascular Diseases
    Cluster Analysis
    Comorbidity
    Cystitis, Interstitial
    Depression
    Fatigue Syndrome, Chronic
    Female
    Fibromyalgia
    Humans
    Irritable Bowel Syndrome
    Male
    Middle Aged
    Migraine Disorders
    Prevalence
    Psychology
    Quality of Life
    Retrospective Studies
    Sex Offenses
    Syncope

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17578536

    Citation

    Tietjen, Gretchen E., et al. "Migraine Comorbidity Constellations." Headache, vol. 47, no. 6, 2007, pp. 857-65.
    Tietjen GE, Herial NA, Hardgrove J, et al. Migraine comorbidity constellations. Headache. 2007;47(6):857-65.
    Tietjen, G. E., Herial, N. A., Hardgrove, J., Utley, C., & White, L. (2007). Migraine comorbidity constellations. Headache, 47(6), pp. 857-65.
    Tietjen GE, et al. Migraine Comorbidity Constellations. Headache. 2007;47(6):857-65. PubMed PMID: 17578536.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Migraine comorbidity constellations. AU - Tietjen,Gretchen E, AU - Herial,Nabeel A, AU - Hardgrove,Jacqueline, AU - Utley,Christine, AU - White,Leah, PY - 2007/6/21/pubmed PY - 2007/8/2/medline PY - 2007/6/21/entrez SP - 857 EP - 65 JF - Headache JO - Headache VL - 47 IS - 6 N2 - OBJECTIVES: To identify distinct constellations of comorbid disorders occurring in migraineurs, and to examine differences in demographics, headache profiles, and psychosocial features between the comorbidity constellations. METHODS: This is a retrospective electronic chart review of consecutive new female outpatients diagnosed with migraine (n = 223) using International Classification of Headache Disorders (ICHD)-II criteria. Questionnaire collected information on comorbid diagnoses, current depression, somatic symptoms, psychosocial stressors, and antidepressant use, social and abuse history. Cluster analysis, based on nonheadache disorders, was performed and differences between the resulting groups were examined. RESULTS: We identified 3 groups. Group 1 (n = 55) was defined by hypertension, hyperlipidemia, diabetes mellitus, and hypothyroidism; Group 2 (n = 83) by depression, anxiety, and fibromyalgia; Group 3 (n = 85) by the absence of defining comorbidities. Group 1 had more males (22% vs 5% vs 12%, P < .05), was older (median years: 52 vs 36 vs 32, P < .01), and had later age of headache onset (median years: 22 vs 16 vs 18, P < .05). Group 2 had the greatest disability (P < .05), and the lowest quality of life (P < .001). Persons in Group 2 more commonly reported sexual abuse (OR = 2.7, 95% CI: 1.1 to 6.5), physical abuse (OR = 2.5, 95% CI: 1.2 to 5.1), and emotional abuse (OR = 4.3, 95% CI: 1.9 to 8.9). CONCLUSION: Within a headache clinic population, we identified 3 different migraine comorbidity constellations, with differing headache and psychosocial profiles, suggesting heterogeneity of genetic and environmental factors. This may have implications for diagnosis and disease management. SN - 0017-8748 UR - https://www.unboundmedicine.com/medline/citation/17578536/Migraine_comorbidity_constellations_ L2 - https://doi.org/10.1111/j.1526-4610.2007.00814.x DB - PRIME DP - Unbound Medicine ER -