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Rheumatoid factors antedating clinical rheumatoid arthritis.
J Rheumatol. 1991 Sep; 18(9):1282-4.JR

Abstract

The relationship between rheumatoid factors (RF) and rheumatoid arthritis (RA) was studied in the Mini-Finland Health Survey. This covered a representative sample of the Finnish population over 30 years of age, initially comprising 8,000 persons, of whom 7,217 participated in the field survey carried out in 1978-80. The participants were followed using record linkage with the Social Insurance Institution's population register to identify patients entitled to free medication. Until the end of 1988, 21 persons had developed new seropositive RA. In 15 cases, preillness specimens contained elevated levels (greater than or equal to 20 IU/ml) of RF. In the remaining 6 cases with RF negative preillness specimens, the interval from taking the blood specimen to the onset of disease was 4 years or more. RF represent a key element in the rheumatoid inflammatory process. Their occurrence in preillness specimens suggests that they may have a primary role in the pathogenesis of the disease.

Authors+Show Affiliations

National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1757925

Citation

Aho, K, et al. "Rheumatoid Factors Antedating Clinical Rheumatoid Arthritis." The Journal of Rheumatology, vol. 18, no. 9, 1991, pp. 1282-4.
Aho K, Heliövaara M, Maatela J, et al. Rheumatoid factors antedating clinical rheumatoid arthritis. J Rheumatol. 1991;18(9):1282-4.
Aho, K., Heliövaara, M., Maatela, J., Tuomi, T., & Palosuo, T. (1991). Rheumatoid factors antedating clinical rheumatoid arthritis. The Journal of Rheumatology, 18(9), 1282-4.
Aho K, et al. Rheumatoid Factors Antedating Clinical Rheumatoid Arthritis. J Rheumatol. 1991;18(9):1282-4. PubMed PMID: 1757925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rheumatoid factors antedating clinical rheumatoid arthritis. AU - Aho,K, AU - Heliövaara,M, AU - Maatela,J, AU - Tuomi,T, AU - Palosuo,T, PY - 1991/9/1/pubmed PY - 1991/9/1/medline PY - 1991/9/1/entrez SP - 1282 EP - 4 JF - The Journal of rheumatology JO - J Rheumatol VL - 18 IS - 9 N2 - The relationship between rheumatoid factors (RF) and rheumatoid arthritis (RA) was studied in the Mini-Finland Health Survey. This covered a representative sample of the Finnish population over 30 years of age, initially comprising 8,000 persons, of whom 7,217 participated in the field survey carried out in 1978-80. The participants were followed using record linkage with the Social Insurance Institution's population register to identify patients entitled to free medication. Until the end of 1988, 21 persons had developed new seropositive RA. In 15 cases, preillness specimens contained elevated levels (greater than or equal to 20 IU/ml) of RF. In the remaining 6 cases with RF negative preillness specimens, the interval from taking the blood specimen to the onset of disease was 4 years or more. RF represent a key element in the rheumatoid inflammatory process. Their occurrence in preillness specimens suggests that they may have a primary role in the pathogenesis of the disease. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/1757925/Rheumatoid_factors_antedating_clinical_rheumatoid_arthritis_ L2 - https://www.diseaseinfosearch.org/result/9254 DB - PRIME DP - Unbound Medicine ER -