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Restless legs syndrome in Parkinson's disease.
Mov Disord. 2007 Oct 15; 22(13):1912-6.MD

Abstract

The present study explores the frequency of RLS in PD and focuses on the clinical differences between patients with and without restless legs syndrome (RLS). A cross-sectional study was designed, comprising 114 patients diagnosed with PD. Those patients positive for RLS were assessed for intensity of the syndrome (IRLS). We compared the clinical characteristics of the patients with and without RLS, using specific scales: Unified Parkinson's Disease Rating Scale (UPDRS I-IV), quality of life (Parkinson's Disease Questionnaire, PDQ 39), sleep symptoms (Parkinson's Disease Sleep Scale, PDSS), and diurnal hypersomnia (Epworth Sleepiness Scale). Twenty-five patients (21.9%) out of a total of 114 subjects diagnosed with PD met the RLS diagnostic criteria. RLS was more frequent in women (68%). The patients with RLS showed poorer scores on the PDSS (PD-RLS+: 102.4 +/- 15.1 vs PD-RLS-: 113.2 +/- 16.4) (P = 0.005) and in the bodily discomfort dimension of the PDQ-39 (PD-RLS+ 6.1 +/- 3.4 vs PD-RLS- 3.8 +/- 2.6) (P = 0.002). Analysis of the subscales of the PDSS showed significant differences (P < 0.001) between both groups of patients in items 4 and 10, and to a lesser degree in items 5 (P = 0.01) and 11 (P = 0.02) There was no increased incidence of diurnal hypersomnia in the group of patients with RLS. There were no differences in the rest of the variables. RLS is frequent in patients with PD, though this condition doesn't apparently affect quality of life or lead to an increased presence of diurnal hypersomnia. It would be advisable to validate the diagnostic criteria of RLS in this specific group of patients.

Authors+Show Affiliations

Neurology Service, Movement Disorders Unit, Hospital Cruces, Baracaldo, Vizcaya. jgomeze@meditex.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17579369

Citation

Gómez-Esteban, Juan C., et al. "Restless Legs Syndrome in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 22, no. 13, 2007, pp. 1912-6.
Gómez-Esteban JC, Zarranz JJ, Tijero B, et al. Restless legs syndrome in Parkinson's disease. Mov Disord. 2007;22(13):1912-6.
Gómez-Esteban, J. C., Zarranz, J. J., Tijero, B., Velasco, F., Barcena, J., Rouco, I., Lezcano, E., Lachen, M. C., Jauregui, A., & Ugarte, A. (2007). Restless legs syndrome in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 22(13), 1912-6.
Gómez-Esteban JC, et al. Restless Legs Syndrome in Parkinson's Disease. Mov Disord. 2007 Oct 15;22(13):1912-6. PubMed PMID: 17579369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restless legs syndrome in Parkinson's disease. AU - Gómez-Esteban,Juan C, AU - Zarranz,Juan J, AU - Tijero,Beatriz, AU - Velasco,Fernando, AU - Barcena,Joseba, AU - Rouco,Idoia, AU - Lezcano,Elena, AU - Lachen,María C, AU - Jauregui,Amaia, AU - Ugarte,Amaia, PY - 2007/6/21/pubmed PY - 2008/3/22/medline PY - 2007/6/21/entrez SP - 1912 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 22 IS - 13 N2 - The present study explores the frequency of RLS in PD and focuses on the clinical differences between patients with and without restless legs syndrome (RLS). A cross-sectional study was designed, comprising 114 patients diagnosed with PD. Those patients positive for RLS were assessed for intensity of the syndrome (IRLS). We compared the clinical characteristics of the patients with and without RLS, using specific scales: Unified Parkinson's Disease Rating Scale (UPDRS I-IV), quality of life (Parkinson's Disease Questionnaire, PDQ 39), sleep symptoms (Parkinson's Disease Sleep Scale, PDSS), and diurnal hypersomnia (Epworth Sleepiness Scale). Twenty-five patients (21.9%) out of a total of 114 subjects diagnosed with PD met the RLS diagnostic criteria. RLS was more frequent in women (68%). The patients with RLS showed poorer scores on the PDSS (PD-RLS+: 102.4 +/- 15.1 vs PD-RLS-: 113.2 +/- 16.4) (P = 0.005) and in the bodily discomfort dimension of the PDQ-39 (PD-RLS+ 6.1 +/- 3.4 vs PD-RLS- 3.8 +/- 2.6) (P = 0.002). Analysis of the subscales of the PDSS showed significant differences (P < 0.001) between both groups of patients in items 4 and 10, and to a lesser degree in items 5 (P = 0.01) and 11 (P = 0.02) There was no increased incidence of diurnal hypersomnia in the group of patients with RLS. There were no differences in the rest of the variables. RLS is frequent in patients with PD, though this condition doesn't apparently affect quality of life or lead to an increased presence of diurnal hypersomnia. It would be advisable to validate the diagnostic criteria of RLS in this specific group of patients. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17579369/Restless_legs_syndrome_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.21624 DB - PRIME DP - Unbound Medicine ER -