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[Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers].
Cir Esp 2007; 82(1):27-31CE

Abstract

INTRODUCTION

Diabetic foot is a complication of diabetes mellitus that manifests with the development of ulcers that frequently precede amputation. Several studies have verified that the environment of the diabetic neuropathic foot ulcer contains a high concentration of metalloproteinases. The aim of the present study was to evaluate the efficacy of a protease-modulating dressing in the treatment of neuropathic diabetic foot ulcers.

MATERIAL AND METHOD

A randomized controlled trial was conducted in 40 patients with a 6-week or longer history of neuropathic diabetic foot ulcer. The patients were randomized to two groups: group 1 (n = 20) received treatment with the protease-modulating dressing while the control group (group 2; n = 20) received the treatment specified in the standardized protocol for good wound care. The patients were then followed-up for 6 weeks.

RESULTS

After 6 weeks, healing was achieved in 12 patients (63% of n = 19) in group 1 under treatment with the protease-modulating dressing versus three patients (15% of n = 19) in the control group (p < 0.03). The mean time to healing was 23.3 +/- 9.9 days in group 1 and 40.6 +/- 1.15 days in group 2 (p < 0.01).

CONCLUSIONS

The results confirm the hypothesis that the use of protease-modulating dressings in patients with neuropathic diabetic foot ulcers leads to better tissue regeneration than good wound care.

Authors+Show Affiliations

Unidad de Pie Diabético, Clínica Universitaria de Podología, Universidad Complutense de Madrid, Madrid, Spain. diabetes@enf.ucm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

spa

PubMed ID

17580028

Citation

Lázaro-Martínez, José Luis, et al. "[Randomized Comparative Trial of a Collagen/oxidized Regenerated Cellulose Dressing in the Treatment of Neuropathic Diabetic Foot Ulcers]." Cirugia Espanola, vol. 82, no. 1, 2007, pp. 27-31.
Lázaro-Martínez JL, García-Morales E, Beneit-Montesinos JV, et al. [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. Cir Esp. 2007;82(1):27-31.
Lázaro-Martínez, J. L., García-Morales, E., Beneit-Montesinos, J. V., Martínez-de-Jesús, F. R., & Aragón-Sánchez, F. J. (2007). [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. Cirugia Espanola, 82(1), pp. 27-31.
Lázaro-Martínez JL, et al. [Randomized Comparative Trial of a Collagen/oxidized Regenerated Cellulose Dressing in the Treatment of Neuropathic Diabetic Foot Ulcers]. Cir Esp. 2007;82(1):27-31. PubMed PMID: 17580028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. AU - Lázaro-Martínez,José Luis, AU - García-Morales,Esther, AU - Beneit-Montesinos,Juan V, AU - Martínez-de-Jesús,Fermín R, AU - Aragón-Sánchez,Francisco Javier, PY - 2007/6/21/pubmed PY - 2007/11/6/medline PY - 2007/6/21/entrez SP - 27 EP - 31 JF - Cirugia espanola JO - Cir Esp VL - 82 IS - 1 N2 - INTRODUCTION: Diabetic foot is a complication of diabetes mellitus that manifests with the development of ulcers that frequently precede amputation. Several studies have verified that the environment of the diabetic neuropathic foot ulcer contains a high concentration of metalloproteinases. The aim of the present study was to evaluate the efficacy of a protease-modulating dressing in the treatment of neuropathic diabetic foot ulcers. MATERIAL AND METHOD: A randomized controlled trial was conducted in 40 patients with a 6-week or longer history of neuropathic diabetic foot ulcer. The patients were randomized to two groups: group 1 (n = 20) received treatment with the protease-modulating dressing while the control group (group 2; n = 20) received the treatment specified in the standardized protocol for good wound care. The patients were then followed-up for 6 weeks. RESULTS: After 6 weeks, healing was achieved in 12 patients (63% of n = 19) in group 1 under treatment with the protease-modulating dressing versus three patients (15% of n = 19) in the control group (p < 0.03). The mean time to healing was 23.3 +/- 9.9 days in group 1 and 40.6 +/- 1.15 days in group 2 (p < 0.01). CONCLUSIONS: The results confirm the hypothesis that the use of protease-modulating dressings in patients with neuropathic diabetic foot ulcers leads to better tissue regeneration than good wound care. SN - 0009-739X UR - https://www.unboundmedicine.com/medline/citation/17580028/[Randomized_comparative_trial_of_a_collagen/oxidized_regenerated_cellulose_dressing_in_the_treatment_of_neuropathic_diabetic_foot_ulcers]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0009-739X/82/27 DB - PRIME DP - Unbound Medicine ER -