Tags

Type your tag names separated by a space and hit enter

[Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers].

Abstract

INTRODUCTION

Diabetic foot is a complication of diabetes mellitus that manifests with the development of ulcers that frequently precede amputation. Several studies have verified that the environment of the diabetic neuropathic foot ulcer contains a high concentration of metalloproteinases. The aim of the present study was to evaluate the efficacy of a protease-modulating dressing in the treatment of neuropathic diabetic foot ulcers.

MATERIAL AND METHOD

A randomized controlled trial was conducted in 40 patients with a 6-week or longer history of neuropathic diabetic foot ulcer. The patients were randomized to two groups: group 1 (n = 20) received treatment with the protease-modulating dressing while the control group (group 2; n = 20) received the treatment specified in the standardized protocol for good wound care. The patients were then followed-up for 6 weeks.

RESULTS

After 6 weeks, healing was achieved in 12 patients (63% of n = 19) in group 1 under treatment with the protease-modulating dressing versus three patients (15% of n = 19) in the control group (p < 0.03). The mean time to healing was 23.3 +/- 9.9 days in group 1 and 40.6 +/- 1.15 days in group 2 (p < 0.01).

CONCLUSIONS

The results confirm the hypothesis that the use of protease-modulating dressings in patients with neuropathic diabetic foot ulcers leads to better tissue regeneration than good wound care.

Links

  • FREE Publisher Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Unidad de Pie Diabético, Clínica Universitaria de Podología, Universidad Complutense de Madrid, Madrid, Spain. diabetes@enf.ucm.es

    , , ,

    Source

    Cirugia espanola 82:1 2007 Jul pg 27-31

    MeSH

    Bandages
    Cellulose
    Collagen
    Diabetic Foot
    Diabetic Neuropathies
    Female
    Humans
    Male
    Middle Aged
    Oxidation-Reduction
    Prospective Studies

    Pub Type(s)

    Comparative Study
    English Abstract
    Journal Article
    Randomized Controlled Trial

    Language

    spa

    PubMed ID

    17580028

    Citation

    Lázaro-Martínez, José Luis, et al. "[Randomized Comparative Trial of a Collagen/oxidized Regenerated Cellulose Dressing in the Treatment of Neuropathic Diabetic Foot Ulcers]." Cirugia Espanola, vol. 82, no. 1, 2007, pp. 27-31.
    Lázaro-Martínez JL, García-Morales E, Beneit-Montesinos JV, et al. [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. Cir Esp. 2007;82(1):27-31.
    Lázaro-Martínez, J. L., García-Morales, E., Beneit-Montesinos, J. V., Martínez-de-Jesús, F. R., & Aragón-Sánchez, F. J. (2007). [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. Cirugia Espanola, 82(1), pp. 27-31.
    Lázaro-Martínez JL, et al. [Randomized Comparative Trial of a Collagen/oxidized Regenerated Cellulose Dressing in the Treatment of Neuropathic Diabetic Foot Ulcers]. Cir Esp. 2007;82(1):27-31. PubMed PMID: 17580028.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers]. AU - Lázaro-Martínez,José Luis, AU - García-Morales,Esther, AU - Beneit-Montesinos,Juan V, AU - Martínez-de-Jesús,Fermín R, AU - Aragón-Sánchez,Francisco Javier, PY - 2007/6/21/pubmed PY - 2007/11/6/medline PY - 2007/6/21/entrez SP - 27 EP - 31 JF - Cirugia espanola JO - Cir Esp VL - 82 IS - 1 N2 - INTRODUCTION: Diabetic foot is a complication of diabetes mellitus that manifests with the development of ulcers that frequently precede amputation. Several studies have verified that the environment of the diabetic neuropathic foot ulcer contains a high concentration of metalloproteinases. The aim of the present study was to evaluate the efficacy of a protease-modulating dressing in the treatment of neuropathic diabetic foot ulcers. MATERIAL AND METHOD: A randomized controlled trial was conducted in 40 patients with a 6-week or longer history of neuropathic diabetic foot ulcer. The patients were randomized to two groups: group 1 (n = 20) received treatment with the protease-modulating dressing while the control group (group 2; n = 20) received the treatment specified in the standardized protocol for good wound care. The patients were then followed-up for 6 weeks. RESULTS: After 6 weeks, healing was achieved in 12 patients (63% of n = 19) in group 1 under treatment with the protease-modulating dressing versus three patients (15% of n = 19) in the control group (p < 0.03). The mean time to healing was 23.3 +/- 9.9 days in group 1 and 40.6 +/- 1.15 days in group 2 (p < 0.01). CONCLUSIONS: The results confirm the hypothesis that the use of protease-modulating dressings in patients with neuropathic diabetic foot ulcers leads to better tissue regeneration than good wound care. SN - 0009-739X UR - https://www.unboundmedicine.com/medline/citation/17580028/[Randomized_comparative_trial_of_a_collagen/oxidized_regenerated_cellulose_dressing_in_the_treatment_of_neuropathic_diabetic_foot_ulcers]_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0009-739X/82/27 DB - PRIME DP - Unbound Medicine ER -