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[Current aspects of transformation of morphological changes in children with nephrotic syndrome depending on the treatment regimen].
Urologiia. 2007 Mar-AprU

Abstract

Despite existence of broad spectrum of medicine for treatment of childhood nephrotic syndrome, treatment efficiency of childhood nephrotic syndrome is not satisfactory yet. The aim of the study was investigation of clinical and histological changes during treatment of childhood nephrotic syndrome. Patients from the control group were treated with steroids according to ISKDC regimen and those of the study group-- with "long alternate day" regimen of steroids. Efficacy of the treatment was assessed by the relapse rate, rate of ESKD, glomerular filtration rate, proteinuria severity. The results showed a low relapse rate, ESKD, FSGS and proteinuria in the study group. Thus, long alternate day steroid regimen can reduce the number of relapses and improve outcomes in children with nephrotic syndrome by reducing transformation of histological pattern of NS to FSGS.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
English Abstract
Journal Article

Language

rus

PubMed ID

17580388

Citation

Sharipov, A M., and K A. Khamzaeva. "[Current Aspects of Transformation of Morphological Changes in Children With Nephrotic Syndrome Depending On the Treatment Regimen]." Urologiia (Moscow, Russia : 1999), 2007, pp. 68-71.
Sharipov AM, Khamzaeva KA. [Current aspects of transformation of morphological changes in children with nephrotic syndrome depending on the treatment regimen]. Urologiia. 2007.
Sharipov, A. M., & Khamzaeva, K. A. (2007). [Current aspects of transformation of morphological changes in children with nephrotic syndrome depending on the treatment regimen]. Urologiia (Moscow, Russia : 1999), (2), 68-71.
Sharipov AM, Khamzaeva KA. [Current Aspects of Transformation of Morphological Changes in Children With Nephrotic Syndrome Depending On the Treatment Regimen]. Urologiia. 2007 Mar-Apr;(2)68-71. PubMed PMID: 17580388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Current aspects of transformation of morphological changes in children with nephrotic syndrome depending on the treatment regimen]. AU - Sharipov,A M, AU - Khamzaeva,K A, PY - 2007/6/21/pubmed PY - 2007/7/17/medline PY - 2007/6/21/entrez SP - 68 EP - 71 JF - Urologiia (Moscow, Russia : 1999) JO - Urologiia IS - 2 N2 - Despite existence of broad spectrum of medicine for treatment of childhood nephrotic syndrome, treatment efficiency of childhood nephrotic syndrome is not satisfactory yet. The aim of the study was investigation of clinical and histological changes during treatment of childhood nephrotic syndrome. Patients from the control group were treated with steroids according to ISKDC regimen and those of the study group-- with "long alternate day" regimen of steroids. Efficacy of the treatment was assessed by the relapse rate, rate of ESKD, glomerular filtration rate, proteinuria severity. The results showed a low relapse rate, ESKD, FSGS and proteinuria in the study group. Thus, long alternate day steroid regimen can reduce the number of relapses and improve outcomes in children with nephrotic syndrome by reducing transformation of histological pattern of NS to FSGS. SN - 1728-2985 UR - https://www.unboundmedicine.com/medline/citation/17580388/[Current_aspects_of_transformation_of_morphological_changes_in_children_with_nephrotic_syndrome_depending_on_the_treatment_regimen]_ DB - PRIME DP - Unbound Medicine ER -