[Current aspects of transformation of morphological changes in children with nephrotic syndrome depending on the treatment regimen].Urologiia. 2007 Mar-AprU
Despite existence of broad spectrum of medicine for treatment of childhood nephrotic syndrome, treatment efficiency of childhood nephrotic syndrome is not satisfactory yet. The aim of the study was investigation of clinical and histological changes during treatment of childhood nephrotic syndrome. Patients from the control group were treated with steroids according to ISKDC regimen and those of the study group-- with "long alternate day" regimen of steroids. Efficacy of the treatment was assessed by the relapse rate, rate of ESKD, glomerular filtration rate, proteinuria severity. The results showed a low relapse rate, ESKD, FSGS and proteinuria in the study group. Thus, long alternate day steroid regimen can reduce the number of relapses and improve outcomes in children with nephrotic syndrome by reducing transformation of histological pattern of NS to FSGS.