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Changes in bronchial hyperresponsiveness following high- and low-sulphite wine challenges in wine-sensitive asthmatic patients.
Clin Exp Allergy 2007; 37(7):1062-6CE

Abstract

BACKGROUND

Previous studies suggest that challenge of most wine-sensitive asthmatic patients may not result in a reduction in forced expiratory volume in 1 s (FEV(1)).

OBJECTIVE

The aim of this study was to assess whether changes in bronchial hyperresponsiveness (BHR) occur following wine challenge of asthmatic patients who report sensitivity to wine, and whether such changes could help clarify the role of sulphite additives in wine-induced asthmatic responses.

METHODS

Eight self-reporting wine-sensitive asthmatic patients completed double-blind challenges with high- and low-sulphite wines on separate days. FEV(1) and histamine PC(20) were measured before and after consumption of 150 mL of wine.

RESULTS

None of the eight subjects demonstrated a clinically significant >or=15%) reduction in FEV(1) following challenge with either high- or low-sulphite wine. In contrast, one patient demonstrated clinically significant increase in BHR following challenge with both high- and low-sulphite wines, and a smaller increase in BHR following placebo challenge. A second patient showed a significant increase, while another showed a significant decrease in BHR following challenge with low-sulphite wine. A fourth patient showed borderline increases in BHR following challenge with both high- and low-sulphite wines.

CONCLUSIONS

Although changes in BHR, in the absence of reductions in FEV(1), were observed in some asthmatic patients following wine challenge, these changes were not consistent with a single aetiology. Consequently, this study did not support a major role for the sulphite additives in wine-induced asthmatic responses in the patients studied. The aetiology of wine-induced asthma is likely to be complex and appears to vary among individuals who are sensitive to these drinks.

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    Authors+Show Affiliations

    Vally H
    Lung Institute of Western Australia (Inc.), Centre for Asthma, Allergy and Respiratory Research, Perth, Australia. Hassan.Vally@anu.edu.au
    Thompson PJ
    No affiliation info available
    Misso NL
    No affiliation info available

    MeSH

    AdultAsthmaBronchial HyperreactivityBronchial Provocation TestsDouble-Blind MethodFemaleForced Expiratory VolumeHumansMaleMiddle AgedSulfitesWine

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17581200

    Citation

    Vally, H, et al. "Changes in Bronchial Hyperresponsiveness Following High- and Low-sulphite Wine Challenges in Wine-sensitive Asthmatic Patients." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 37, no. 7, 2007, pp. 1062-6.
    Vally H, Thompson PJ, Misso NL. Changes in bronchial hyperresponsiveness following high- and low-sulphite wine challenges in wine-sensitive asthmatic patients. Clin Exp Allergy. 2007;37(7):1062-6.
    Vally, H., Thompson, P. J., & Misso, N. L. (2007). Changes in bronchial hyperresponsiveness following high- and low-sulphite wine challenges in wine-sensitive asthmatic patients. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 37(7), pp. 1062-6.
    Vally H, Thompson PJ, Misso NL. Changes in Bronchial Hyperresponsiveness Following High- and Low-sulphite Wine Challenges in Wine-sensitive Asthmatic Patients. Clin Exp Allergy. 2007;37(7):1062-6. PubMed PMID: 17581200.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Changes in bronchial hyperresponsiveness following high- and low-sulphite wine challenges in wine-sensitive asthmatic patients. AU - Vally,H, AU - Thompson,P J, AU - Misso,N L A, PY - 2007/6/22/pubmed PY - 2007/10/12/medline PY - 2007/6/22/entrez SP - 1062 EP - 6 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 37 IS - 7 N2 - BACKGROUND: Previous studies suggest that challenge of most wine-sensitive asthmatic patients may not result in a reduction in forced expiratory volume in 1 s (FEV(1)). OBJECTIVE: The aim of this study was to assess whether changes in bronchial hyperresponsiveness (BHR) occur following wine challenge of asthmatic patients who report sensitivity to wine, and whether such changes could help clarify the role of sulphite additives in wine-induced asthmatic responses. METHODS: Eight self-reporting wine-sensitive asthmatic patients completed double-blind challenges with high- and low-sulphite wines on separate days. FEV(1) and histamine PC(20) were measured before and after consumption of 150 mL of wine. RESULTS: None of the eight subjects demonstrated a clinically significant >or=15%) reduction in FEV(1) following challenge with either high- or low-sulphite wine. In contrast, one patient demonstrated clinically significant increase in BHR following challenge with both high- and low-sulphite wines, and a smaller increase in BHR following placebo challenge. A second patient showed a significant increase, while another showed a significant decrease in BHR following challenge with low-sulphite wine. A fourth patient showed borderline increases in BHR following challenge with both high- and low-sulphite wines. CONCLUSIONS: Although changes in BHR, in the absence of reductions in FEV(1), were observed in some asthmatic patients following wine challenge, these changes were not consistent with a single aetiology. Consequently, this study did not support a major role for the sulphite additives in wine-induced asthmatic responses in the patients studied. The aetiology of wine-induced asthma is likely to be complex and appears to vary among individuals who are sensitive to these drinks. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/17581200/Changes_in_bronchial_hyperresponsiveness_following_high__and_low_sulphite_wine_challenges_in_wine_sensitive_asthmatic_patients_ L2 - https://doi.org/10.1111/j.1365-2222.2007.02747.x DB - PRIME DP - Unbound Medicine ER -