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Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia.
Psychiatry Res. 2007 Sep 30; 153(1):77-81.PR

Abstract

There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n=262) and healthy controls (n=263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population.

Authors+Show Affiliations

Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seocho-Gu, Seoul, South Korea. pae@catholic.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17582511

Citation

Pae, Chi-Un, et al. "Manganese Superoxide Dismutase (MnSOD: Ala-9Val) Gene Polymorphism May Not Be Associated With Schizophrenia and Tardive Dyskinesia." Psychiatry Research, vol. 153, no. 1, 2007, pp. 77-81.
Pae CU, Kim TS, Patkar AA, et al. Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia. Psychiatry Res. 2007;153(1):77-81.
Pae, C. U., Kim, T. S., Patkar, A. A., Kim, J. J., Lee, C. U., Lee, S. J., Jun, T. Y., Lee, C., & Paik, I. H. (2007). Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia. Psychiatry Research, 153(1), 77-81.
Pae CU, et al. Manganese Superoxide Dismutase (MnSOD: Ala-9Val) Gene Polymorphism May Not Be Associated With Schizophrenia and Tardive Dyskinesia. Psychiatry Res. 2007 Sep 30;153(1):77-81. PubMed PMID: 17582511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism may not be associated with schizophrenia and tardive dyskinesia. AU - Pae,Chi-Un, AU - Kim,Tae-Suk, AU - Patkar,Ashwin A, AU - Kim,Jung-Jin, AU - Lee,Chang-Uk, AU - Lee,Soo-Jung, AU - Jun,Tae-Youn, AU - Lee,Chul, AU - Paik,In-Ho, Y1 - 2007/06/19/ PY - 2005/11/29/received PY - 2006/03/06/revised PY - 2006/04/20/accepted PY - 2007/6/22/pubmed PY - 2008/1/10/medline PY - 2007/6/22/entrez SP - 77 EP - 81 JF - Psychiatry research JO - Psychiatry Res VL - 153 IS - 1 N2 - There has been increasing evidence that the alteration of antioxidant enzymes such as manganese superoxide dismutase (MnSOD) might be implicated in the development of schizophrenia and/or tardive dyskinesia (TD). This study investigated the association of a MnSOD gene (MnSOD) polymorphism (Ala-9Val) with schizophrenia as well as its involvement in TD. Patients with schizophrenia (n=262) and healthy controls (n=263) were enrolled in this study and genotyped by a polymerase chain reaction-based method. The distribution of the MnSOD genotypes and alleles was not significantly different between patients and controls. Logistic regression analysis also failed to reveal any association between MnSOD genotypes and TD. Taken together, these results suggest that the MnSOD polymorphism does not contribute to the development of schizophrenia and/or TD, at least in the Korean population. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/17582511/Manganese_superoxide_dismutase__MnSOD:_Ala_9Val__gene_polymorphism_may_not_be_associated_with_schizophrenia_and_tardive_dyskinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(06)00112-0 DB - PRIME DP - Unbound Medicine ER -