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Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy.
J Appl Toxicol. 2008 Apr; 28(3):271-82.JA

Abstract

Adriamycin is an effective anthracycline anti-tumor antibiotic. However, the clinical use of adriamycin has been restricted by its serious side effects. Some reports indicated that the side effects of adriamycin could cause systemic injury, in which reactive oxygen species (ROS) play an important role. ROS are a large family of oxygen free radical and non-free radical active oxygen-containing molecules, including superoxide radical, hydrogen peroxide and hydroxyl radical, which contribute to oxidative stress. Although antioxidant treatment is a promising method to prevent the side effects, protection by a single antioxidant is limited. The Chinese herbal medicine ANTIOXIN is a multiple antioxidant that can effectively block oxidative stress. It was hypothesized that ANTIOXIN could effectively reduce the side effects of adriamycin. A rat tumor model with a transplanted tumor in the liver was treated with adriamycin and ANTIOXIN was used as a protection. Oxidative stress and antioxidant enzymes were evaluated. The results showed that adriamycin chemotherapy increased the level of malondialdehyde (MDA), nitrogen oxide (NO) and decreased the activities of total superoxide dismutase (T-SOD), manganese superoxide dismutase (MnSOD), catalase (CAT), glutathione (GSH) and total antioxidant capacity (TAC). Adriamycin chemotherapy also decreased the expression of Bcl-2, increased the expression of iNOS and cell apoptosis in the liver and kidney. Multiple antioxidants ANTIOXIN had an antagonistic effect on these changes and significantly decreased the mortality of the experimental rats. These data demonstrated that adriamycin chemotherapy could cause oxidative stress to the whole body, on which multiple antioxidants based on the theory of 'multiple antioxidant chain' had effective protection.

Authors+Show Affiliations

Department of Toxicology, the Fourth Military Medical University, Xi'an, 710032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17582587

Citation

Qin, Xu-Jun, et al. "Protection of Multiple Antioxidants Chinese Herbal Medicine On the Oxidative Stress Induced By Adriamycin Chemotherapy." Journal of Applied Toxicology : JAT, vol. 28, no. 3, 2008, pp. 271-82.
Qin XJ, He W, Hai CX, et al. Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy. J Appl Toxicol. 2008;28(3):271-82.
Qin, X. J., He, W., Hai, C. X., Liang, X., & Liu, R. (2008). Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy. Journal of Applied Toxicology : JAT, 28(3), 271-82.
Qin XJ, et al. Protection of Multiple Antioxidants Chinese Herbal Medicine On the Oxidative Stress Induced By Adriamycin Chemotherapy. J Appl Toxicol. 2008;28(3):271-82. PubMed PMID: 17582587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protection of multiple antioxidants Chinese herbal medicine on the oxidative stress induced by adriamycin chemotherapy. AU - Qin,Xu-Jun, AU - He,Wei, AU - Hai,Chun-Xu, AU - Liang,Xin, AU - Liu,Rui, PY - 2007/6/22/pubmed PY - 2008/6/13/medline PY - 2007/6/22/entrez SP - 271 EP - 82 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 28 IS - 3 N2 - Adriamycin is an effective anthracycline anti-tumor antibiotic. However, the clinical use of adriamycin has been restricted by its serious side effects. Some reports indicated that the side effects of adriamycin could cause systemic injury, in which reactive oxygen species (ROS) play an important role. ROS are a large family of oxygen free radical and non-free radical active oxygen-containing molecules, including superoxide radical, hydrogen peroxide and hydroxyl radical, which contribute to oxidative stress. Although antioxidant treatment is a promising method to prevent the side effects, protection by a single antioxidant is limited. The Chinese herbal medicine ANTIOXIN is a multiple antioxidant that can effectively block oxidative stress. It was hypothesized that ANTIOXIN could effectively reduce the side effects of adriamycin. A rat tumor model with a transplanted tumor in the liver was treated with adriamycin and ANTIOXIN was used as a protection. Oxidative stress and antioxidant enzymes were evaluated. The results showed that adriamycin chemotherapy increased the level of malondialdehyde (MDA), nitrogen oxide (NO) and decreased the activities of total superoxide dismutase (T-SOD), manganese superoxide dismutase (MnSOD), catalase (CAT), glutathione (GSH) and total antioxidant capacity (TAC). Adriamycin chemotherapy also decreased the expression of Bcl-2, increased the expression of iNOS and cell apoptosis in the liver and kidney. Multiple antioxidants ANTIOXIN had an antagonistic effect on these changes and significantly decreased the mortality of the experimental rats. These data demonstrated that adriamycin chemotherapy could cause oxidative stress to the whole body, on which multiple antioxidants based on the theory of 'multiple antioxidant chain' had effective protection. SN - 0260-437X UR - https://www.unboundmedicine.com/medline/citation/17582587/Protection_of_multiple_antioxidants_Chinese_herbal_medicine_on_the_oxidative_stress_induced_by_adriamycin_chemotherapy_ L2 - https://doi.org/10.1002/jat.1276 DB - PRIME DP - Unbound Medicine ER -