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Fibre intake and renal cell carcinoma: a case-control study from Italy.

Abstract

Only 2 previous studies, conducted in Australia, United States and northern Europe, considered the role of dietary fibre intake on renal cell carcinoma (RCC) risk, and both showed a modest, inverse association. Therefore, we investigated in depth the topic of fibres and RCC, using data from a multicenter case-control study conducted in Italy from 1992 to 2004, including 767 cases with incident, histologically confirmed RCC and 1,534 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. The continuous OR for an increase in intake equal to the difference between the 80th and the 20th percentile were 0.94 (95% CI: 0.82-1.08) for total dietary fibre, 0.98 (95% CI: 0.85-1.13) for soluble noncellulose polysaccharides, 0.92 (95% CI: 0.80-1.05) for total insoluble fibre, 0.90 (95% CI: 0.78-1.04) for cellulose, 0.95 (95% CI: 0.84-1.06) for insoluble noncellulose polysaccharides and 1.06 (95% CI: 0.93-1.21) for lignin. With reference to the sources of fibre, we found an inverse association with vegetable fibre (OR = 0.84, 95% CI: 0.73-0.97), but no association with fruit (OR = 0.98, 95% CI: 0.86-1.12) and grain fibre (OR = 1.05, 95% CI: 0.95-1.15). The inverse association with vegetable fibre may reflect a real favorable effect, or be an indicator of a beneficial role of a diet rich in vegetable on RCC risk.

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  • Authors+Show Affiliations

    ,

    Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. galeone@marionegri.it

    , , , , , , , ,

    Source

    International journal of cancer 121:8 2007 Oct 15 pg 1869-72

    MeSH

    Aged
    Carcinoma, Renal Cell
    Case-Control Studies
    Dietary Fiber
    Edible Grain
    Feeding Behavior
    Female
    Fruit
    Humans
    Incidence
    Italy
    Kidney Neoplasms
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Risk Assessment
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17582601

    Citation

    Galeone, Carlotta, et al. "Fibre Intake and Renal Cell Carcinoma: a Case-control Study From Italy." International Journal of Cancer, vol. 121, no. 8, 2007, pp. 1869-72.
    Galeone C, Pelucchi C, Talamini R, et al. Fibre intake and renal cell carcinoma: a case-control study from Italy. Int J Cancer. 2007;121(8):1869-72.
    Galeone, C., Pelucchi, C., Talamini, R., Negri, E., Montella, M., Ramazzotti, V., ... La Vecchia, C. (2007). Fibre intake and renal cell carcinoma: a case-control study from Italy. International Journal of Cancer, 121(8), pp. 1869-72.
    Galeone C, et al. Fibre Intake and Renal Cell Carcinoma: a Case-control Study From Italy. Int J Cancer. 2007 Oct 15;121(8):1869-72. PubMed PMID: 17582601.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fibre intake and renal cell carcinoma: a case-control study from Italy. AU - Galeone,Carlotta, AU - Pelucchi,Claudio, AU - Talamini,Renato, AU - Negri,Eva, AU - Montella,Maurizio, AU - Ramazzotti,Valerio, AU - Zucchetto,Antonella, AU - Dal Maso,Luigino, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, PY - 2007/6/22/pubmed PY - 2007/10/30/medline PY - 2007/6/22/entrez SP - 1869 EP - 72 JF - International journal of cancer JO - Int. J. Cancer VL - 121 IS - 8 N2 - Only 2 previous studies, conducted in Australia, United States and northern Europe, considered the role of dietary fibre intake on renal cell carcinoma (RCC) risk, and both showed a modest, inverse association. Therefore, we investigated in depth the topic of fibres and RCC, using data from a multicenter case-control study conducted in Italy from 1992 to 2004, including 767 cases with incident, histologically confirmed RCC and 1,534 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. The continuous OR for an increase in intake equal to the difference between the 80th and the 20th percentile were 0.94 (95% CI: 0.82-1.08) for total dietary fibre, 0.98 (95% CI: 0.85-1.13) for soluble noncellulose polysaccharides, 0.92 (95% CI: 0.80-1.05) for total insoluble fibre, 0.90 (95% CI: 0.78-1.04) for cellulose, 0.95 (95% CI: 0.84-1.06) for insoluble noncellulose polysaccharides and 1.06 (95% CI: 0.93-1.21) for lignin. With reference to the sources of fibre, we found an inverse association with vegetable fibre (OR = 0.84, 95% CI: 0.73-0.97), but no association with fruit (OR = 0.98, 95% CI: 0.86-1.12) and grain fibre (OR = 1.05, 95% CI: 0.95-1.15). The inverse association with vegetable fibre may reflect a real favorable effect, or be an indicator of a beneficial role of a diet rich in vegetable on RCC risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17582601/Fibre_intake_and_renal_cell_carcinoma:_a_case_control_study_from_Italy_ L2 - https://doi.org/10.1002/ijc.22913 DB - PRIME DP - Unbound Medicine ER -