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[Research on the differentially expressed genes related to the relatively specific connection between the heart meridian and the heart].
Zhen Ci Yan Jiu. 2007 Feb; 32(1):3-8.ZC

Abstract

OBJECTIVE

To study the scientific basis of specific correlation between the meridian and the Zang- or Fu organ by using gene differential expression (gene-chip technique) in the rat.

METHODS

Twenty-one SD rats were randomly and evenly divided into control group, sham-myocardial ischemia (MI) group, MI group, electroacupuncture (EA)-Heart-Meridian (HT) group, EA-Lung-Meridian (LU) group and EA-Small-Intestine-Meridian (SI) group. EA (frequency 2 Hz, stimulating strength 5 V, pulse duration 300 mus) was applied to "Shenmen" (HT 7)- "Tongli" (HT 5) (Heart Meridian), "Y anglao" (SI 6)- "Zhizheng" (SI 7) (Small Intestine Meridian), "Taiyuan" (LU 9)-"Lieque" (LU 7) (Lung Meridian) for 20 min, once daily and continuously for 3 days. Myocardial ischemia model was duplicated by occlusion of the anterior descending branch of the left coronary artery, and myocardial tissue of the left ventricle was taken 3 days after EA treatment for analyzing the differentially expressed genes in different groups with rat whole gene U 230 sequence chips (offered by Affymetrix Company).

RESULTS

Compared with model group, among the differentially expressed genes being twofolds and above, the up-regulated and the down-regulated were 20 and 70 in EA-HT group, 18 and 26 in EA-SI group, and 14 and 20 in EA-LU group separately. Few same genes with the same differential expression were found among the 3 EA groups.

CONCLUSION

There is exactly a molecular basis in the correlation between Heart Meridian and the heart, and EA of Heart Meridian, Small Intestine Meridian and Lung Meridian have their own special signaling pathways.

Authors+Show Affiliations

Center for Researching Correlation Between Meridians and Zangfu-organs, Anhui College of Chinese Medicine, Hefei 230038, China. zhouyp@mail.hf.ah.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17582876

Citation

Zhou, Yi-Ping, et al. "[Research On the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 32, no. 1, 2007, pp. 3-8.
Zhou YP, Wang KM, Hu L, et al. [Research on the differentially expressed genes related to the relatively specific connection between the heart meridian and the heart]. Zhen Ci Yan Jiu. 2007;32(1):3-8.
Zhou, Y. P., Wang, K. M., Hu, L., Wu, Z. J., Zhou, M. Q., Wang, Y. L., Yang, H. T., Zhang, F. B., & Sun, L. (2007). [Research on the differentially expressed genes related to the relatively specific connection between the heart meridian and the heart]. Zhen Ci Yan Jiu = Acupuncture Research, 32(1), 3-8.
Zhou YP, et al. [Research On the Differentially Expressed Genes Related to the Relatively Specific Connection Between the Heart Meridian and the Heart]. Zhen Ci Yan Jiu. 2007;32(1):3-8. PubMed PMID: 17582876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Research on the differentially expressed genes related to the relatively specific connection between the heart meridian and the heart]. AU - Zhou,Yi-Ping, AU - Wang,Ke-Ming, AU - Hu,Ling, AU - Wu,Zi-Jian, AU - Zhou,Mei-Qi, AU - Wang,Yue-Lan, AU - Yang,Huang-Tian, AU - Zhang,Fa-Bao, AU - Sun,Lu, PY - 2007/6/23/pubmed PY - 2007/7/21/medline PY - 2007/6/23/entrez SP - 3 EP - 8 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 32 IS - 1 N2 - OBJECTIVE: To study the scientific basis of specific correlation between the meridian and the Zang- or Fu organ by using gene differential expression (gene-chip technique) in the rat. METHODS: Twenty-one SD rats were randomly and evenly divided into control group, sham-myocardial ischemia (MI) group, MI group, electroacupuncture (EA)-Heart-Meridian (HT) group, EA-Lung-Meridian (LU) group and EA-Small-Intestine-Meridian (SI) group. EA (frequency 2 Hz, stimulating strength 5 V, pulse duration 300 mus) was applied to "Shenmen" (HT 7)- "Tongli" (HT 5) (Heart Meridian), "Y anglao" (SI 6)- "Zhizheng" (SI 7) (Small Intestine Meridian), "Taiyuan" (LU 9)-"Lieque" (LU 7) (Lung Meridian) for 20 min, once daily and continuously for 3 days. Myocardial ischemia model was duplicated by occlusion of the anterior descending branch of the left coronary artery, and myocardial tissue of the left ventricle was taken 3 days after EA treatment for analyzing the differentially expressed genes in different groups with rat whole gene U 230 sequence chips (offered by Affymetrix Company). RESULTS: Compared with model group, among the differentially expressed genes being twofolds and above, the up-regulated and the down-regulated were 20 and 70 in EA-HT group, 18 and 26 in EA-SI group, and 14 and 20 in EA-LU group separately. Few same genes with the same differential expression were found among the 3 EA groups. CONCLUSION: There is exactly a molecular basis in the correlation between Heart Meridian and the heart, and EA of Heart Meridian, Small Intestine Meridian and Lung Meridian have their own special signaling pathways. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/17582876/[Research_on_the_differentially_expressed_genes_related_to_the_relatively_specific_connection_between_the_heart_meridian_and_the_heart]_ DB - PRIME DP - Unbound Medicine ER -