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Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
J Agric Food Chem. 2007 Jul 25; 55(15):6013-7.JA

Abstract

Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice.

Authors+Show Affiliations

Biotechnology Research Laboratories, Takara Bio Inc., 3-4-1 Seta, Otsu, Shiga, 520-2193, Japan. enokit@takara-bio.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17583349

Citation

Enoki, Tatsuji, et al. "Antidiabetic Activities of Chalcones Isolated From a Japanese Herb, Angelica Keiskei." Journal of Agricultural and Food Chemistry, vol. 55, no. 15, 2007, pp. 6013-7.
Enoki T, Ohnogi H, Nagamine K, et al. Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. J Agric Food Chem. 2007;55(15):6013-7.
Enoki, T., Ohnogi, H., Nagamine, K., Kudo, Y., Sugiyama, K., Tanabe, M., Kobayashi, E., Sagawa, H., & Kato, I. (2007). Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. Journal of Agricultural and Food Chemistry, 55(15), 6013-7.
Enoki T, et al. Antidiabetic Activities of Chalcones Isolated From a Japanese Herb, Angelica Keiskei. J Agric Food Chem. 2007 Jul 25;55(15):6013-7. PubMed PMID: 17583349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. AU - Enoki,Tatsuji, AU - Ohnogi,Hiromu, AU - Nagamine,Kinuko, AU - Kudo,Yoko, AU - Sugiyama,Katsumi, AU - Tanabe,Masashige, AU - Kobayashi,Eiji, AU - Sagawa,Hiroaki, AU - Kato,Ikunoshin, Y1 - 2007/06/21/ PY - 2007/6/23/pubmed PY - 2007/10/10/medline PY - 2007/6/23/entrez SP - 6013 EP - 7 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 55 IS - 15 N2 - Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb "Ashitaba", Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-gamma activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/17583349/Antidiabetic_activities_of_chalcones_isolated_from_a_Japanese_Herb_Angelica_keiskei_ L2 - https://dx.doi.org/10.1021/jf070720q DB - PRIME DP - Unbound Medicine ER -