Tags

Type your tag names separated by a space and hit enter

Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from India.

Abstract

Hypopharyngeal and laryngeal cancers are among the most common cancers in India. In addition to smoking, tobacco chewing may be a major risk factor for some of these cancers in India. Using data from a multicentric case-control study conducted in India that included 513 hypopharyngeal cancer cases, 511 laryngeal cancer cases and 718 controls, we investigated smoking and chewing tobacco products as risk factors for these cancers. Bidi smoking was a stronger risk factor compared to cigarette smoking for cancer of the hypopharynx (OR(bidi) 6.80 vs. OR(cig) 3.82) and supraglottis (OR(bidi) 7.53 vs. OR(cig) 2.14), while the effect of the 2 products was similar for cancer of the glottis (OR(bidi) 5.32 vs. OR(cig) 5.74). Among never-smokers, tobacco chewing was a risk factor for hypopharyngeal cancer, but not for laryngeal cancer. In particular, the risk of hypopharyngeal cancer increased with the use of Khaini (OR 2.02, CI 0.81-5.05), Mawa (OR 3.17, CI 1.06-9.53), Pan (OR 3.34, CI 1.68-6.61), Zarda (OR 3.58, CI 1.20-10.68) and Gutkha (OR 4.59, CI 1.21-17.49). A strong dose-response relationship was observed between chewing frequency and the risk of hypopharyngeal cancer (p(trend) < 0.001). An effect of alcohol on cancer of the hypopharynx and supraglottis was observed only among daily drinkers (OR 2.22, CI 1.11-4.45 and OR 3.76, CI 1.25-11.30, respectively). In summary, this study shows that chewing tobacco products commercially available in India are risk factors for hypopharyngeal cancer, and that the potency of Bidi smoking may be higher than that of cigarette smoking for hypopharyngeal and laryngeal cancers.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    International Agency for Research on Cancer, Lyon, France.

    , , , , , ,

    Source

    International journal of cancer 121:8 2007 Oct 15 pg 1793-8

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Case-Control Studies
    Dose-Response Relationship, Drug
    Female
    Humans
    Hypopharyngeal Neoplasms
    India
    Laryngeal Neoplasms
    Male
    Middle Aged
    Risk Assessment
    Risk Factors
    Smoking
    Time Factors
    Tobacco, Smokeless

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17583577

    Citation

    Sapkota, Amir, et al. "Smokeless Tobacco and Increased Risk of Hypopharyngeal and Laryngeal Cancers: a Multicentric Case-control Study From India." International Journal of Cancer, vol. 121, no. 8, 2007, pp. 1793-8.
    Sapkota A, Gajalakshmi V, Jetly DH, et al. Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from India. Int J Cancer. 2007;121(8):1793-8.
    Sapkota, A., Gajalakshmi, V., Jetly, D. H., Roychowdhury, S., Dikshit, R. P., Brennan, P., ... Boffetta, P. (2007). Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from India. International Journal of Cancer, 121(8), pp. 1793-8.
    Sapkota A, et al. Smokeless Tobacco and Increased Risk of Hypopharyngeal and Laryngeal Cancers: a Multicentric Case-control Study From India. Int J Cancer. 2007 Oct 15;121(8):1793-8. PubMed PMID: 17583577.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from India. AU - Sapkota,Amir, AU - Gajalakshmi,Vendhan, AU - Jetly,Dhaval H, AU - Roychowdhury,Soma, AU - Dikshit,Rajesh P, AU - Brennan,Paul, AU - Hashibe,Mia, AU - Boffetta,Paolo, PY - 2007/6/23/pubmed PY - 2007/10/30/medline PY - 2007/6/23/entrez SP - 1793 EP - 8 JF - International journal of cancer JO - Int. J. Cancer VL - 121 IS - 8 N2 - Hypopharyngeal and laryngeal cancers are among the most common cancers in India. In addition to smoking, tobacco chewing may be a major risk factor for some of these cancers in India. Using data from a multicentric case-control study conducted in India that included 513 hypopharyngeal cancer cases, 511 laryngeal cancer cases and 718 controls, we investigated smoking and chewing tobacco products as risk factors for these cancers. Bidi smoking was a stronger risk factor compared to cigarette smoking for cancer of the hypopharynx (OR(bidi) 6.80 vs. OR(cig) 3.82) and supraglottis (OR(bidi) 7.53 vs. OR(cig) 2.14), while the effect of the 2 products was similar for cancer of the glottis (OR(bidi) 5.32 vs. OR(cig) 5.74). Among never-smokers, tobacco chewing was a risk factor for hypopharyngeal cancer, but not for laryngeal cancer. In particular, the risk of hypopharyngeal cancer increased with the use of Khaini (OR 2.02, CI 0.81-5.05), Mawa (OR 3.17, CI 1.06-9.53), Pan (OR 3.34, CI 1.68-6.61), Zarda (OR 3.58, CI 1.20-10.68) and Gutkha (OR 4.59, CI 1.21-17.49). A strong dose-response relationship was observed between chewing frequency and the risk of hypopharyngeal cancer (p(trend) < 0.001). An effect of alcohol on cancer of the hypopharynx and supraglottis was observed only among daily drinkers (OR 2.22, CI 1.11-4.45 and OR 3.76, CI 1.25-11.30, respectively). In summary, this study shows that chewing tobacco products commercially available in India are risk factors for hypopharyngeal cancer, and that the potency of Bidi smoking may be higher than that of cigarette smoking for hypopharyngeal and laryngeal cancers. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17583577/Smokeless_tobacco_and_increased_risk_of_hypopharyngeal_and_laryngeal_cancers:_a_multicentric_case_control_study_from_India_ L2 - https://doi.org/10.1002/ijc.22832 DB - PRIME DP - Unbound Medicine ER -