Tags

Type your tag names separated by a space and hit enter

Comparison of the efficacy of local narrowband ultraviolet B (NB-UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis.
J Dermatol. 2007 Jul; 34(7):435-40.JD

Abstract

Palmoplantar psoriasis is an idiopathic disabling condition, often resistant to conventional therapies. The purpose of this study was to evaluate the efficacy and safety of local narrowband ultraviolet B (NB-UVB) phototherapy and to compare it with local psoralen plus ultraviolet A (PUVA) paint in patients with palmoplantar psoriasis unresponsive to conventional therapies other than phototherapy. A cohort of 25 patients with palmoplantar psoriasis were included in this study, which was based on a left-to-right comparison pattern. The treatments were administered with local narrowband UVB irradiation on one side and local PUVA on the other side three times a week over 9 weeks. Clinical assessments were performed at baseline and every 3 weeks during the 9-week treatment. There was a statistically significant decrease in the mean clinical scores at the third, sixth and ninth week with both treatments. The difference in clinical response between the two treatment modalities was statistically significant at the end of the treatment period, with the percentage reduction in severity index scores with the PUVA-paint-treated side being 85.45% compared with 61.08% for the NB-UVB treated side (t = 5.379, P = 0.0001, Student's t-test for unpaired samples). Our results show that, although some clinical improvement was achieved with local NB-UVB phototherapy, the results were better with local PUVA, and such a treatment option may be reserved for patients with palmoplantar psoriasis who experience phototoxic reaction to psoralens.

Authors+Show Affiliations

Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey. eseze@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17584319

Citation

Sezer, Engin, et al. "Comparison of the Efficacy of Local Narrowband Ultraviolet B (NB-UVB) Phototherapy Versus Psoralen Plus Ultraviolet a (PUVA) Paint for Palmoplantar Psoriasis." The Journal of Dermatology, vol. 34, no. 7, 2007, pp. 435-40.
Sezer E, Erbil AH, Kurumlu Z, et al. Comparison of the efficacy of local narrowband ultraviolet B (NB-UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis. J Dermatol. 2007;34(7):435-40.
Sezer, E., Erbil, A. H., Kurumlu, Z., Taştan, H. B., & Etikan, I. (2007). Comparison of the efficacy of local narrowband ultraviolet B (NB-UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis. The Journal of Dermatology, 34(7), 435-40.
Sezer E, et al. Comparison of the Efficacy of Local Narrowband Ultraviolet B (NB-UVB) Phototherapy Versus Psoralen Plus Ultraviolet a (PUVA) Paint for Palmoplantar Psoriasis. J Dermatol. 2007;34(7):435-40. PubMed PMID: 17584319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the efficacy of local narrowband ultraviolet B (NB-UVB) phototherapy versus psoralen plus ultraviolet A (PUVA) paint for palmoplantar psoriasis. AU - Sezer,Engin, AU - Erbil,Ahmet Hakan, AU - Kurumlu,Zafer, AU - Taştan,Halis Bülent, AU - Etikan,Ilker, PY - 2007/6/23/pubmed PY - 2007/9/26/medline PY - 2007/6/23/entrez SP - 435 EP - 40 JF - The Journal of dermatology JO - J. Dermatol. VL - 34 IS - 7 N2 - Palmoplantar psoriasis is an idiopathic disabling condition, often resistant to conventional therapies. The purpose of this study was to evaluate the efficacy and safety of local narrowband ultraviolet B (NB-UVB) phototherapy and to compare it with local psoralen plus ultraviolet A (PUVA) paint in patients with palmoplantar psoriasis unresponsive to conventional therapies other than phototherapy. A cohort of 25 patients with palmoplantar psoriasis were included in this study, which was based on a left-to-right comparison pattern. The treatments were administered with local narrowband UVB irradiation on one side and local PUVA on the other side three times a week over 9 weeks. Clinical assessments were performed at baseline and every 3 weeks during the 9-week treatment. There was a statistically significant decrease in the mean clinical scores at the third, sixth and ninth week with both treatments. The difference in clinical response between the two treatment modalities was statistically significant at the end of the treatment period, with the percentage reduction in severity index scores with the PUVA-paint-treated side being 85.45% compared with 61.08% for the NB-UVB treated side (t = 5.379, P = 0.0001, Student's t-test for unpaired samples). Our results show that, although some clinical improvement was achieved with local NB-UVB phototherapy, the results were better with local PUVA, and such a treatment option may be reserved for patients with palmoplantar psoriasis who experience phototoxic reaction to psoralens. SN - 0385-2407 UR - https://www.unboundmedicine.com/medline/citation/17584319/Comparison_of_the_efficacy_of_local_narrowband_ultraviolet_B__NB_UVB__phototherapy_versus_psoralen_plus_ultraviolet_A__PUVA__paint_for_palmoplantar_psoriasis_ L2 - https://doi.org/10.1111/j.1346-8138.2007.00306.x DB - PRIME DP - Unbound Medicine ER -