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[Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational diabetes mellitus].
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jun; 27(6):799-801.NF

Abstract

OBJECTIVE

To investigate the association of serum concentration of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) with insulin resistance in women with gestational diabetes mellitus (GDM).

METHODS

Forty normal pregnant women (NGT group) and 23 women with GDM (GDM group) were enrolled in this study with another 25 women of child-bearing age as the control group. Radio immunoassay (RIA) was used to measure the fasting serum IL-6 levels, and immunoturbidimetry performed to evaluate serum hs-CRP levels. The homeostasis model assessment-insulin resistance (HOMA-IR) and the homeostasis model assessment-B (HOMA-B) were calculated.

RESULTS

Compared with NGT group and control group, GDM group had significantly elevated serum IL-6 and hs-CRP (P<0.01), but the levels were comparable between the former two groups (P>0.05). HOMA-IR was the highest in GDM group (P<0.001), and NGT group had significantly higher HOMA-IR than the control group (P<0.05), whereas the reverse was true for HOMA-B (P<0.01). Pearson correlation analysis showed that fasting blood glucose (FBG), fasting insulin (FINS), IL-6 and hs-CRP had significant association with HOMA-IR (P<0.01). Multiple regression analysis identified FINS, FBG, IL-6, and hs-CRP as the factors significantly affecting HOMA-IR (regression coefficient of 0.563, 0.992, 0.325, and 0.231, respectively, P<0.01).

CONCLUSIONS

Serum levels of IL-6 and hs-CRP are elevated in women with GDM, which are the most significant factors affecting HOMA-IR. IL-6 and CRP may aggravate insulin resistance through various mechanisms and participate in the pathogenesis of GDM.

Authors+Show Affiliations

Department of Endocrinology, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China. grfyu@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17584642

Citation

Yu, Fang, et al. "[Association of Serum Interleukin-6 and High-sensitivity C-reactive Protein Levels With Insulin Resistance in Gestational Diabetes Mellitus]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 27, no. 6, 2007, pp. 799-801.
Yu F, Xue YM, Li CZ, et al. [Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational diabetes mellitus]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(6):799-801.
Yu, F., Xue, Y. M., Li, C. Z., Shen, J., Gao, F., Yu, Y. H., & Fu, X. J. (2007). [Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational diabetes mellitus]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 27(6), 799-801.
Yu F, et al. [Association of Serum Interleukin-6 and High-sensitivity C-reactive Protein Levels With Insulin Resistance in Gestational Diabetes Mellitus]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27(6):799-801. PubMed PMID: 17584642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational diabetes mellitus]. AU - Yu,Fang, AU - Xue,Yao-ming, AU - Li,Chen-zhong, AU - Shen,Jie, AU - Gao,Fang, AU - Yu,Yan-hong, AU - Fu,Xia-jun, PY - 2007/6/23/pubmed PY - 2010/6/11/medline PY - 2007/6/23/entrez SP - 799 EP - 801 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 27 IS - 6 N2 - OBJECTIVE: To investigate the association of serum concentration of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) with insulin resistance in women with gestational diabetes mellitus (GDM). METHODS: Forty normal pregnant women (NGT group) and 23 women with GDM (GDM group) were enrolled in this study with another 25 women of child-bearing age as the control group. Radio immunoassay (RIA) was used to measure the fasting serum IL-6 levels, and immunoturbidimetry performed to evaluate serum hs-CRP levels. The homeostasis model assessment-insulin resistance (HOMA-IR) and the homeostasis model assessment-B (HOMA-B) were calculated. RESULTS: Compared with NGT group and control group, GDM group had significantly elevated serum IL-6 and hs-CRP (P<0.01), but the levels were comparable between the former two groups (P>0.05). HOMA-IR was the highest in GDM group (P<0.001), and NGT group had significantly higher HOMA-IR than the control group (P<0.05), whereas the reverse was true for HOMA-B (P<0.01). Pearson correlation analysis showed that fasting blood glucose (FBG), fasting insulin (FINS), IL-6 and hs-CRP had significant association with HOMA-IR (P<0.01). Multiple regression analysis identified FINS, FBG, IL-6, and hs-CRP as the factors significantly affecting HOMA-IR (regression coefficient of 0.563, 0.992, 0.325, and 0.231, respectively, P<0.01). CONCLUSIONS: Serum levels of IL-6 and hs-CRP are elevated in women with GDM, which are the most significant factors affecting HOMA-IR. IL-6 and CRP may aggravate insulin resistance through various mechanisms and participate in the pathogenesis of GDM. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/17584642/[Association_of_serum_interleukin_6_and_high_sensitivity_C_reactive_protein_levels_with_insulin_resistance_in_gestational_diabetes_mellitus]_ DB - PRIME DP - Unbound Medicine ER -