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Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine.
Nature. 1991 Dec 19-26; 354(6354):520-2.Nat

Abstract

Rabies infection of domestic and wild animals is a serious problem throughout the world. The major disease vector in Europe is the red fox (Vulpes vulpes) and rabies control has focused on vaccinating and/or culling foxes. Culling has not been effective, and the distribution of five vaccine baits is the only appropriate method for the vaccination of wild foxes. Although some European countries have conducted field vaccination campaigns using attenuated rabies virus strains, their use has not been extensively approved because they retain pathogenicity for rodents and can revert to virulence. These strains cannot be used in North America because they are pathogenic for the striped skunk (Mephitis mephitis) and are ineffective in the raccoon (Procyon lotor). We have constructed a recombinant vaccinia virus, VVTGgRAB, expressing the surface glycoprotein (G) of rabies virus (ERA strain). The recombinant was a highly effective vaccine in experimental animals, in captive foxes and in raccoons. We report here the results of a large-scale campaign of fox vaccination in a 2,200 km2 region of southern Belgium, an area in which rabies is prevalent. After distribution, 81% of foxes inspected were positive for tetracycline, a biomarker included in the vaccine bait and, other than one rabid fox detected close to the periphery of the treated area, no case of rabies, either in foxes or in domestic livestock, has been reported in the area.

Authors+Show Affiliations

Department of Virology, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1758494

Citation

Brochier, B, et al. "Large-scale Eradication of Rabies Using Recombinant Vaccinia-rabies Vaccine." Nature, vol. 354, no. 6354, 1991, pp. 520-2.
Brochier B, Kieny MP, Costy F, et al. Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature. 1991;354(6354):520-2.
Brochier, B., Kieny, M. P., Costy, F., Coppens, P., Bauduin, B., Lecocq, J. P., Languet, B., Chappuis, G., Desmettre, P., & Afiademanyo, K. (1991). Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature, 354(6354), 520-2.
Brochier B, et al. Large-scale Eradication of Rabies Using Recombinant Vaccinia-rabies Vaccine. Nature. 1991 Dec 19-26;354(6354):520-2. PubMed PMID: 1758494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. A1 - Brochier,B, AU - Kieny,M P, AU - Costy,F, AU - Coppens,P, AU - Bauduin,B, AU - Lecocq,J P, AU - Languet,B, AU - Chappuis,G, AU - Desmettre,P, AU - Afiademanyo,K, PY - 1991/12/19/pubmed PY - 1991/12/19/medline PY - 1991/12/19/entrez SP - 520 EP - 2 JF - Nature JO - Nature VL - 354 IS - 6354 N2 - Rabies infection of domestic and wild animals is a serious problem throughout the world. The major disease vector in Europe is the red fox (Vulpes vulpes) and rabies control has focused on vaccinating and/or culling foxes. Culling has not been effective, and the distribution of five vaccine baits is the only appropriate method for the vaccination of wild foxes. Although some European countries have conducted field vaccination campaigns using attenuated rabies virus strains, their use has not been extensively approved because they retain pathogenicity for rodents and can revert to virulence. These strains cannot be used in North America because they are pathogenic for the striped skunk (Mephitis mephitis) and are ineffective in the raccoon (Procyon lotor). We have constructed a recombinant vaccinia virus, VVTGgRAB, expressing the surface glycoprotein (G) of rabies virus (ERA strain). The recombinant was a highly effective vaccine in experimental animals, in captive foxes and in raccoons. We report here the results of a large-scale campaign of fox vaccination in a 2,200 km2 region of southern Belgium, an area in which rabies is prevalent. After distribution, 81% of foxes inspected were positive for tetracycline, a biomarker included in the vaccine bait and, other than one rabid fox detected close to the periphery of the treated area, no case of rabies, either in foxes or in domestic livestock, has been reported in the area. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/1758494/Large_scale_eradication_of_rabies_using_recombinant_vaccinia_rabies_vaccine_ L2 - https://doi.org/10.1038/354520a0 DB - PRIME DP - Unbound Medicine ER -