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The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure.
J Ren Nutr. 2007 Jul; 17(4):258-63.JR

Abstract

BACKGROUND

Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic renal failure (CRF). C-reactive protein (CRP), a strong independent risk marker of CVD, is elevated in a large proportion of patients with CRF. The long-chain n-3 polyunsaturated fatty acids (PUFA) have cardioprotective effects, which may be partly attributed to their anti-inflammatory properties.

OBJECTIVE

The study objective was to investigate the effect of n-3 PUFA on serum levels of CRP in patients with CRF.

DESIGN

We performed a randomized, double-blind, placebo-controlled study.

SETTING

The study took place at an outpatients clinic at the Department of Nephrology, Aalborg Hospital, Denmark.

PATIENTS

The study comprised 46 patients (30 men and 16 women; mean age 59 +/- 11 years) with a serum creatinine level in the range of 150 to 400 micromol/L.

INTERVENTION

The patients were randomly assigned to daily supplementation with 2.4 g n-3 PUFA or identical capsules containing 2.4 g of olive oil (control) for 8 weeks.

MAIN OUTCOME MEASURE

CRP was measured with a high-sensitivity C-reactive protein (hs-CRP) assay and the content of n-3 PUFA in granulocyte membranes before and after supplementation.

RESULTS

The n-3 PUFA concentration increased in granulocytes after the n-3 PUFA supplements but was unaltered by the control oil. A nonsignificant reduction in hs-CRP was observed in the n-3 PUFA group after supplementation (2.46 vs. 1.47 mg/L; P = .06), and hs-CRP was unaltered by the control oil (3.27 vs. 3.14 mg/L; P = .12). There was no difference in median hs-CRP change in the two groups.

CONCLUSION

A trend was seen toward a reduction in hs-CRP in the n-3 PUFA group, but there was no significant difference in hs-CRP levels when both groups were compared.

Authors+Show Affiliations

Department of Cardiology and Cardiovascular Research Centre, Aalborg Hospital, Arhus University Hospital, Aalborg, Denmark. tmadsen@dadlnet.dk <tmadsen@dadlnet.dk>No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17586424

Citation

Madsen, Trine, et al. "The Effect of N-3 Fatty Acids On C-reactive Protein Levels in Patients With Chronic Renal Failure." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 17, no. 4, 2007, pp. 258-63.
Madsen T, Schmidt EB, Christensen JH. The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure. J Ren Nutr. 2007;17(4):258-63.
Madsen, T., Schmidt, E. B., & Christensen, J. H. (2007). The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 17(4), 258-63.
Madsen T, Schmidt EB, Christensen JH. The Effect of N-3 Fatty Acids On C-reactive Protein Levels in Patients With Chronic Renal Failure. J Ren Nutr. 2007;17(4):258-63. PubMed PMID: 17586424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure. AU - Madsen,Trine, AU - Schmidt,Erik B, AU - Christensen,Jeppe H, PY - 2005/11/26/received PY - 2007/6/26/pubmed PY - 2007/7/21/medline PY - 2007/6/26/entrez SP - 258 EP - 63 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 17 IS - 4 N2 - BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic renal failure (CRF). C-reactive protein (CRP), a strong independent risk marker of CVD, is elevated in a large proportion of patients with CRF. The long-chain n-3 polyunsaturated fatty acids (PUFA) have cardioprotective effects, which may be partly attributed to their anti-inflammatory properties. OBJECTIVE: The study objective was to investigate the effect of n-3 PUFA on serum levels of CRP in patients with CRF. DESIGN: We performed a randomized, double-blind, placebo-controlled study. SETTING: The study took place at an outpatients clinic at the Department of Nephrology, Aalborg Hospital, Denmark. PATIENTS: The study comprised 46 patients (30 men and 16 women; mean age 59 +/- 11 years) with a serum creatinine level in the range of 150 to 400 micromol/L. INTERVENTION: The patients were randomly assigned to daily supplementation with 2.4 g n-3 PUFA or identical capsules containing 2.4 g of olive oil (control) for 8 weeks. MAIN OUTCOME MEASURE: CRP was measured with a high-sensitivity C-reactive protein (hs-CRP) assay and the content of n-3 PUFA in granulocyte membranes before and after supplementation. RESULTS: The n-3 PUFA concentration increased in granulocytes after the n-3 PUFA supplements but was unaltered by the control oil. A nonsignificant reduction in hs-CRP was observed in the n-3 PUFA group after supplementation (2.46 vs. 1.47 mg/L; P = .06), and hs-CRP was unaltered by the control oil (3.27 vs. 3.14 mg/L; P = .12). There was no difference in median hs-CRP change in the two groups. CONCLUSION: A trend was seen toward a reduction in hs-CRP in the n-3 PUFA group, but there was no significant difference in hs-CRP levels when both groups were compared. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/17586424/The_effect_of_n_3_fatty_acids_on_C_reactive_protein_levels_in_patients_with_chronic_renal_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(07)00094-5 DB - PRIME DP - Unbound Medicine ER -